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APOE4 Increases Neurons’ Excitability Before Symptoms Appear
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1].
A Target for Ameliorating Post-Operative Delirium
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer
Insilico and Eli Lilly Announce a Major Collaboration
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software
How an Enzyme’s Depletion Makes Fat Worse
In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of
Becoming Well-Fed and Sedentary Accelerates Penguin Aging
A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated aging and
Rejuvenation Roundup March 2026
For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let’s see what’s been done last month to rejuvenate animals and people. Team and Activities Support
Modified Immune Cells Target Cancer’s Metabolic Signature
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune
How a Growth Factor and SIRT1 Might Combat Disc Degeneration
Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of lower back
Rubedo Announces Positive Preliminary Results for RLS-1496
Rubedo Life Sciences, Inc. (Rubedo), an AI-driven, clinical-stage biotech focused on discovering and rapidly developing selective cellular rejuvenation medicines targeting aging cells, today announced preliminary results from a single-center, ascending-dose,
Mitochondria Delivery Method Rescues Parkinson’s in Mice
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. The delivery problem
Cellular Senescence and Senotherapeutics: The Expert Roundup
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in longevity medicine.
Two Polyunsaturated Lipids Demonstrate Senolytic Activity
A new study identified two polyunsaturated fatty acids, α-eleostearic acid (α-ESA) and α-ESA methyl ester (α-ESA-me), that showed senolytic activity in cell cultures and a mouse model [1]. An anti-aging
BioAge Labs Provides Business Updates
BioAge Labs, Inc. (“BioAge”, “the Company”), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging, today provided financial results for
In Vivo Created CAR T Cells Eliminate Tumors in Mice
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher efficacy across
Buck Institute Launches Healthspan Horizons
The Buck Institute for Research on Aging today announced the launch of Healthspan Horizons, a new initiative designed to address one of the most urgent challenges in modern medicine: how
Neuroscience of Vitality and Aging Conference in Boston
For the first time, the Neuroscience of Vitality and Aging (NOVA) Conference is bringing together leaders from across neuroscience, biotechnology, policy, and investment to examine one of the most
When Doctors Prescribe Horoscopes: The Trouble With Biological Age Tests
Imagine this pitch: a simple cheek swab or blood spot mailed from home tells you not your birthday but your “true” biological age – the number that supposedly reflects
Meat Consumption May Benefit APOE4 Carriers
A new study has found a negative association between unprocessed meat consumption and cognitive decline in carriers of the “pro-Alzheimer’s” APOE ε4 allele. This counterintuitive connection might have something
Using mRNA to Fight Tau Aggregation in Alzheimer’s
Researchers publishing in Cell Reports Medicine have described the development of a lipid nanoparticle (LNP) that delivers mRNA to neurons in order to stop the formation of tau aggregates
Negative Interactions Are Associated With Faster Aging
A new study reported an association between having more problematic people in close networks and increased biological aging [1]. A look into the dark side Social connection has been
Study Links a Gut Bacterium to Increased Muscle Strength
Scientists have found a positive correlation between the abundance of the bacterium Roseburia inulinivorans in the gut and muscle strength in mice and humans, although the mechanism behind it
How Zinc Protects Injured Arteries From Accelerated Aging
Researchers publishing in Aging Cell have discovered that the nuclei of the cells that line injured arteries quickly become misshapen and that this leads to accelerated cellular senescence. Delivering
Gut Bacteria Might Affect Cognition via the Vagus Nerve
A new study suggests that microbiome remodeling is a mechanism behind age-related cognitive decline, with one particular bacterial species identified as the likely culprit. In mice, antibiotics seem to
Xplore Program 2026: A Remote Summer Fellowship in Longevity
For the third summer in a row, Longevity Xplorer (LongX) is opening applications for the Xplore Program, a fully remote summer fellowship designed to help students and early-career professionals
Vitalist Bay 2026 Returns to Berkeley May 14–17
BERKELEY, CA — The Vitalism Foundation announces Vitalist Bay 2026, the world’s largest longevity festival, returning to the Lighthaven Campus in Berkeley, California from May 14–17, 2026. Now in
The Many Dangers of 7-Ketocholesterol
A group of researchers, including Matthew O’Connor of Cyclarity Therapeutics, has published a review detailing what effects 7-ketocholesterol (7KC) has in the human body. An oxidized cholesterol 7KC, an
People With Positive Outlooks Have Better Aging Outcomes
A recent study published in Geriatrics debunks the assumption that an older chronological age results in an inevitable and universal decline in health. The researchers reported that a significant
Rejuvenation Biotechnology
Rejuvenation biotechnology is a field that seeks to add more healthy years to human life. There are quite a few misconceptions about our field, so we are going to
Scientists Successfully Freeze and Rewarm Mouse Brain Slices
In a new study, researchers have vitrified mouse brain slices and then a complete brain with encouraging results: upon rewarming, much of the neuronal function was preserved [1]. The
A Review of How the Heart Ages
The European Heart Journal has published a review of what happens to the human heart as it ages, noting the cellular effects of mitochondrial dysfunction and cellular senescence along