Researchers publishing in Aging Cell have found that Hevin, a protein found in the extracellular matrix that increases with age, leads to heart problems in older male […]
By inhibiting the aging-related enzyme 15-PGDH, scientists have shifted cartilage cells towards a healthier phenotype, leading to a significant improvement in a mouse model of osteoarthritis [1]. The […]
In a paper published in Aging Cell, researchers have described how older cells send long interspersed nuclear element-1 (LINE-1) RNA to other cells in extracellular vesicles […]
A recent study investigated biomarkers that can help monitor trajectories of Alzheimer’s disease-related molecular processes, such as neuronal cell death, and how […]
How did the year 2025 turn out for longevity biotech? Was it surprising or more of the same? Exciting or disappointing? Was the […]
Scientists have found that a single microbial species can blunt the negative effects of a high-fat diet due to the unique mix of lipids it produces [1]. They intend to identify its […]
We’re closer to 2050 than to 2000, and technology is advancing apace; this includes technologies that help us stop aging in all its forms. Here’s the highlights […]
Longevity Investors announces the upcoming Longevity Investors Lunch 2026, an exclusive, application-only gathering designed specifically for investors seeking exposure to the most compelling opportunities emerging at […]
A recent review evaluated studies that included over 5.5 million participants to assess the impact of multivitamin and mineral supplements on different aspects of health [1]. A big market Multivitamin and mineral (MVM) supplements are widely used […]
Scientists in Japan have discovered that multiple strains of bacteria taken from frogs, newts, and lizards can be effective against human colon cancer […]
In Aging Cell, researchers have identified bone marrow stromal antigen 2 (BST2) as a key protein in age-related hearing loss in a mouse model. Neural myelination is necessary for function Demyelination, the loss of neurons’ protective […]
A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function [1]. Bringing back the Ts […]
Dr. Maximina Yun, principal investigator at Chinese Institutes for Medical Research in Beijing (CIMR), studies some of the most amazing animals in […]
Why do we age at all, and why do different species age at such dramatically different rates? After decades of longevity research, biologists still disagree on the most basic questions: What is aging? Is it possible […]
In Nature Aging, researchers have discovered growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We have recently reported on a potential treatment for […]
Researchers have investigated the reporting quality of preclinical studies’ outcomes in anti-aging research. They analyzed how study quality changed over time, shortcomings in research, and the improvements that can be made in the future in […]
Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver [1]. The new target The increasing abundance of […]
In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around the body is subcutaneous […]
A new observational study spanning two human cohorts has found a link between theobromine, a phytochemical abundant in cocoa, and slower epigenetic aging [1]. A yummy geroprotector? Popular […]
Comparison of human umbilical cord blood with adult plasma revealed hundreds of metabolites whose abundances were age-dependent. Two different formulas, each a mix of a few metabolites, demonstrated anti-senescence properties in […]
Happy holidays! Winter is in full swing for those of us in the Northern Hemisphere. It is a time for cozy nights by the fire and a great time to catch up on what has been happening at […]
In Aging Cell, researchers have described how an age-related deficiency in another compound leads the antioxidant FoxO1 to contribute to bone deterioration in osteoporosis by siphoning from a bone-building pathway. A harmful antioxidant? Because they fight against harmful reactive […]
In a new study, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) improved spatial working memory in rhesus macaques, suggesting a possible reversal […]
Researchers have discovered that extracellular vesicles (EVs) derived from the nasal mucosa provide significant regenerative benefits to tissues throughout the body, including the brain. A very regenerative tissue Previous work involving the transection of sizable portions of the nasal […]
A new review highlights the promise of microglia replacement, a strategy that made the leap from mouse studies to the first successful human trial in […]
In Nature Aging, researchers have published their finding that targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice. One way the gut lining ages […]
A recent study investigated plasma proteins in people exposed to secondhand smoke and found that exposure affected multiple molecular processes, including immune, inflammatory, […]
In a new study, the amino acid arginine shows promise in animal models of amyloid aggregation due to its ability to promote protein folding. The researchers suggest that it could be useful for early prevention and treatment of Alzheimer’s […]
Many researchers in the United States have finished eating turkey and begun shopping, but their work continues. Here’s what people around the world have been doing to […]
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints […]
