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May 20, 2025
Scientists have created engineered nanostructures that bind monomers and oligomers of harmful amyloid beta (Aβ) protein, preventing them from entering neurons and drastically increasing the cells’ survival in vitro [1]. Don’t let them into cells! Misfolded proteins are thought to be behind diseases like Alzheimer’s and amyotrophic lateral sclerosis (ALS). The most recognizable hallmark of...
May 13, 2025
Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1]. How do we harness the immune system against senescence? Cellular senescence, which occurs when cells subjected to stress stop dividing and start emitting pro-inflammatory signals,...
May 08, 2025
Michael Levin, professor at Tufts University and director of Allen Discovery Center, has been working for years on how bioelectrical patterns affect development and aging. His research proves that this often-overlooked part of biology is immensely important and that mastering its mechanisms might one day do wonders for human health and longevity. By manipulating ion...
April 29, 2025
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to withstand stress [1]. Keeping the balance Geroscientists have long suspected that the immune system plays an outsized role in aging, one that has deep evolutionary...
April 22, 2025
Clonal hematopoiesis, a condition linked to numerous age-related disorders, can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin [1]. The attack of the clones The human body constantly produces vast numbers of blood cells from hematopoietic stem and progenitor cells (HSPCs). Over time, some HSPCs may...
April 14, 2025
In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by Lifespan.io. Crowdfunded research bears fruit Rapamycin: Benefits, Side Effects, and ResearchRapamycin is a macrolide, a class of antibiotic and it exhibits potent antitumor...
