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April 07, 2026
The pro-Alzheimer's allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer's disease begins long before symptoms appear, building silently for decades. The single strongest genetic risk factor for the common, late-onset form of...
April 03, 2026
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software Earlier this week, the AI-driven drug discovery company Insilico Medicine announced a large-scale collaboration with the pharmaceutical giant Eli Lilly. The deal is worth up to...
March 31, 2026
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune cells into the tumor? One of the central challenges in cancer immunotherapy is getting the right immune cells to the right place. Natural killer (NK) cells...
March 27, 2026
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. The delivery problem Mitochondrial diseases are a diverse group of disorders that arise when mitochondria malfunction. They are often caused by mutations in mitochondrial DNA (mtDNA) itself or in...
March 26, 2026
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in longevity medicine. Senescent cells actually serve important roles in development, wound healing, and cancer prevention, but as they accumulate with age or pathology, they become harmful: they secrete...
March 24, 2026
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher efficacy across three cancer types, including a solid tumor [1]. CAR T therapies: promising but imperfect Ideally, T cells, the killer cells of our adaptive immune systems, should...