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November 14, 2025
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer's [1]. Which way to splice it? Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are included in the final RNA transcript, and introns, which...
November 11, 2025
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and reduce side effects [1]. Addressing the adherence problem High levels of LDL cholesterol (LDL-C) and triglycerides are a major risk factor for cardiovascular disease and...
November 07, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a mouse model of Alzheimer’s [1]. Dangerous species Reactive oxygen species (ROS) are short-lived, highly reactive oxygen-containing molecules such as superoxide and hydrogen peroxide that are...
November 04, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions [1]. Macrophages, capillaries, and skin aging Skin aging might not be the most dangerous aspect of aging, but it certainly is one of the most...
October 31, 2025
A new observational study suggests that men need more than twice as much exercise as women do to achieve the same level of reduction in the risk of cardiovascular heart disease [1]. Understanding sex differences In recent years, scientists have questioned how much exercise is needed for tangible health benefits. Current guidelines from the American...
October 28, 2025
In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infections, such as the common cold, COVID-19, and malaria. Science has made great strides against these kinds of infectious diseases, making them less deadly and even...