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March 31, 2026
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune cells into the tumor? One of the central challenges in cancer immunotherapy is getting the right immune cells to the right place. Natural killer (NK) cells...
March 27, 2026
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. The delivery problem Mitochondrial diseases are a diverse group of disorders that arise when mitochondria malfunction. They are often caused by mutations in mitochondrial DNA (mtDNA) itself or in...
March 26, 2026
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in longevity medicine. Senescent cells actually serve important roles in development, wound healing, and cancer prevention, but as they accumulate with age or pathology, they become harmful: they secrete...
March 24, 2026
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher efficacy across three cancer types, including a solid tumor [1]. CAR T therapies: promising but imperfect Ideally, T cells, the killer cells of our adaptive immune systems, should...
March 20, 2026
A new study has found a negative association between unprocessed meat consumption and cognitive decline in carriers of the “pro-Alzheimer’s” APOE ε4 allele. This counterintuitive connection might have something to do with human evolution [1]. The meat connection The APOE gene, which produces apolipoprotein E, a protein central to lipid transport in the brain and...
March 17, 2026
Scientists have found a positive correlation between the abundance of the bacterium Roseburia inulinivorans in the gut and muscle strength in mice and humans, although the mechanism behind it is still unclear [1]. Can bacteria mimic exercise? As we age, we lose muscle mass and strength. This decline is a major driver of frailty, disability,...