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February 13, 2026
Scientists have applied partial reprogramming to memory-encoding neurons (engrams) and achieved memory improvements in Alzheimer’s models and wild-type mice [1]. Rejuvenating neurons Partial cellular reprogramming, which uses certain factors to rejuvenate cells while maintaining their identity) has shown promise across various conditions and cell types, including neurons [2]. Rejuvenating these long-lived brain cells is imperative...
February 10, 2026
A new study links sleep loss to the thinning of the myelin layer, which slows signal transmission in axons. Restoring cholesterol homeostasis reverses the damage [1]. Sleep loss hurts myelin Sleep quality is a strong extrinsic determinant of longevity [2]. Not only does sleep loss affect cognitive function [3], it has also been linked to...
February 06, 2026
Life Biosciences has announced that its trial of cellular reprogramming aimed at two age-related vision diseases has received a go-ahead from the FDA. We spoke with the company’s CSO to get more details. Life Biosciences, the biotech company based on Harvard professor David Sinclair’s research into cellular reprogramming, stunned everyone last year by announcing that...
February 03, 2026
A new study suggests that, if sets are taken close to failure, the amount of weight on the bar does not determine muscle growth. However, individual differences in muscle-building ability appear to be real [1]. How should we train? Muscle mass and strength are among the strongest predictors of longevity, but the best way to...
January 30, 2026
Using an ingenious CRISPR-based screening technique, scientists have found a protein that tags tau for degradation and is more strongly expressed in tau-resilient neurons [1]. Some neurons are more equal than others The accumulation of tau protein fibrils in neurons is a hallmark of Alzheimer’s and several other diseases [2]. Scientists have long noticed that...
January 27, 2026
A new study from the Universities of Oxford and Nottingham has uncovered a potential new mechanism by which rapamycin counters immunosenescence. Rather than increasing autophagy or reducing protein synthesis, the effect appears to involve directly reducing DNA damage burden in immune cells [1]. How can this work? Rapamycin, a powerful inhibitor of the nutrient-sensing mTOR...