Tag: Rapamycin

Combining rapamycin with the anti-cancer drug trametinib produced a synergistic effect and robust life extension in a new study [1]. A multi-node approach Rapamycin, which was first widely used as an immunosuppressant for transplant patients and is also used in oncology, is considered one of the most powerful geroprotectors. In the "gold standard" Interventions Testing...

In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by Lifespan.io. Crowdfunded research bears fruit Rapamycin: Benefits, Side Effects, and ResearchRapamycin is a macrolide, a class of antibiotic and it exhibits potent antitumor...

Ora Biomedical and the Rapamycin Longevity Lab have launched a project to screen more than 600 mTOR inhibitors in the hope of finding some that are superior to geroscience’s poster child, rapamycin. Better than chance Rapamycin, one of the most potent compounds for prolonging lifespan in numerous animal models, was discovered serendipitously in one of...

The authors of a recent review propose that there may be positive synergistic effects from combining mTOR inhibitors and sodium-glucose co-transporter-2 (SGLT-2) inhibitors [1]. Inhibition of two molecules is better than one mTOR is a well-known molecule in aging research. Inhibition of mTOR has been shown to extend lifespan in multiple organisms, including worms, yeast,...

Combining rapamycin and trametinib seemed to have a cumulative effect in both sexes but mostly in females [1]. These results are probably due to a reduction in both cancer and inflammation. A winning combo The idea that combination treatments are the future of life extension is gaining traction. As aging is a complex phenomenon, a...

A recent Molecular Metabolism paper dives into the differences between intermittent and chronic rapamycin treatment and its differential impact on male and female mice [1]. The dark side of rapamycin Rapamycin doesn’t need much introduction in the lifespan extension community. This mTOR inhibitor has been shown multiple times to extend lifespan in animal studies. Because...