Tag: Osteoarthritis

In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work has found a strong link between obesity and osteoarthritis of the knee [1]. While the increased weight itself may be a factor, fatty acids themselves...

Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint health [1]. A centuries-old observation The authors start the article with a quote from the English physician John Haygarth from 1805: the nodosities [irregularities] of...

In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead to osteoarthritis [2], and it has been found to...

In Aging, researchers have reported that deriving extracellular vesicles from mesenchymal stromal cells (MSCs) in fat tissue has beneficial effects in models of osteoarthritis. Which source to use? Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...

A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells' function Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

In Aging Cell, researchers have published details on the pathway by which a compound commonly found in ketone bodies ameliorates osteoarthritis in a rat model. Chondrocytes are crucial in arthritis The cartilage holding joints together is built and maintained by chondrocytes, which synthesize such necessary proteins as collagen and aggrecan [1]. Unfortunately, the cellular senescence...