Tag: Obesity

In Nature Aging, researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function. Not all macrophages follow the same rules Why We Age: Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of...

In Aging Cell, researchers have published their surprising findings that epigenetic clocks are not significantly related to most measurements of metabolic health after weight loss interventions. The utility of clocks Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to...

Scientists have found that visceral fat and subcutaneous fat produce different responses to obesity in male mice and human patients and identified an important regulator of these processes [1]. The tale of the two fats It has been known that visceral fat, which accumulates around organs in the abdomen, and subcutaneous fat, which accumulates under...

Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from the University of California, San Francisco, dare to walk an unbeaten path. Junevity pursues the ambitious goal of fixing age-related transcriptional dysregulation using short interfering...

New research demonstrated how transitioning from a typical Western diet composed of processed foods to a whole-food diet improved cardiometabolic health and body composition and impacted gut microbiome metabolites in elderly people [1]. You are what you eat While this study was conducted in Australia, the foods commonly consumed there are similar to common foods...

A team of researchers has waded into a controversial and contradictory area of study, publishing information on the link between obesity and an inflammatory molecule that increases with aging. A context-dependent molecule The authors point out previous research that singled out the interleukin IL-6, a key immune signaling molecule, as a major contributor to inflammaging...