Tag: Neurons

In Advanced Science, a team of researchers has explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability to older animals. Stress as a signal This paper focuses on Schwann cells, glial cells that are often responsible for maintaining the protective sheaths of myelin around neuronal axons and help peripheral nerves to...

Scientists have discovered a pathway behind the known effect of exercise suppressing appetite: a lactate-related metabolite that acts directly on certain neurons. Not just more calories burned It has been long known that, somewhat counterintuitively, exercise transiently suppresses appetite. Scientists suspect that this contributes to exercise-related weight loss. However, the exact mechanisms behind this effect,...

Researchers publishing in Aging Cell have used single-cell transcriptomics to discover new insights into how neural stem cells (NSCs) change with aging. Adults do generate neurons The adult brain does generate new neurons [1], particularly in the hippocampus, the part of the brain responsible for memory formation [2]. Neurogenesis is limited to very specific niches,...

Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination. Crucial proteins and a well-known intervention Normally, neuronal axons are coated in a protein sheath made of myelin, which is necessary for their proper function [1]. Myelination is most known to be impeded by multiple sclerosis, but...

Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and space Partial cellular reprogramming is one of the hottest directions in longevity research for a reason: it allows to rejuvenate cells without driving them all...

In Aging Cell, researchers have identified a receptor in the brain that appears to be responsible for cognitive problems after surgery, particularly in older people. Surgery can cause cognitive problems Neurological symptoms such as postoperative cognitive dysfunction [1] and postoperative delirium [2] are common after surgery, particularly when the surgery is intensive or the patient...