Tag: Metabolism

Researchers have discovered how and why α-ketoglutaric acid (AKG) affects cellular senescence and how a small molecule may be useful in affecting this process. They published their findings in Cell Reports. A crucial molecule AKG is a major part of multiple fundamental metabolic processes, including the Krebs cycle that mitochondria use to generate energy, and...

In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice. A system tightly tied together This paper begins with a discussion of the relationship between epigenetic alterations and cellular senescence. The histone H3K4me3...

At the University of Wisconsin-Madison, Dr. Rozalyn Anderson is studying one of the oldest-known and yet most powerful anti-aging interventions: caloric restriction (CR). Back in 1935, CR helped launch the entire longevity field when a pioneering study by Clive McCay and his colleagues at Cornell University demonstrated that CR without malnutrition significantly extends the lifespan...

In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations, improvements in behavior and ability, and reduced fearfulness [1]. Therapeutic potential Earlier this year, we reported on a clinical trial in which administering HUCMSCs reduced...

A paper published in Age and Ageing analyzed the intake of different food groups and whether they accelerate or decelerate biological age in post-menopausal women [1]. Nutrition and biological age Biological age is a better indicator of health and aging than chronological age [2]. Multiple measurements can be used to assess biological age; some of...

In Aging, a team of researchers has outlined a possible relationship between low grip strength and compounds in the gut microbiome. The gut-muscle axis As these researchers note, previous work has described many of the various ways in which metabolism is related to age-related muscle dysfunction, including inflammation, oxidative stress, accumulation of advanced glycation end-products...