Summer is heating things up, both in the Northern Hemisphere and in the world of rejuvenation biotechnology. Here’s what’s happened in July.
Team and activities
The 2025 Longevity Summit Dublin: The 2025 Longevity Summit Dublin was held in July, and we have the highlights from the event for you along with the latest research updates and news from the conference.
Interviews
Dr. David Furman on Inflammation and Aging: Dr. David Furman, who has been studying inflammation for many years at Stanford and the Buck Institute for Research on Aging, might be the best authority to talk to about inflammation and aging.
Gabriel Cian on Investment and the 2060 Longevity Forum: In this Lifespan interview, we spoke with Gabriel Cian, founder of the 2060 Longevity Forum, about healthspan innovation, credibility, bottlenecks, and opportunities.
Advocacy and Analysis
The Tale of One Tower: SF-Based Vertical Longevity Village: In downtown San Francisco, an entire tower is becoming a hub for longevity, AI, crypto, and robotics. It just hosted its first longevity conference.
Research Roundup
Study Discovers a Mammalian Mechanism of Tissue Regeneration: Scientists have analyzed the differences between mammalian species that can regrow ear tissue after injury and those that cannot. Their findings can pave the way for novel regenerative therapies.
Healthspan Effects of an Anti-Aging Vaccine on Mice: The researchers of a recent study published in Aging Cell described their novel CD38 peptide vaccine, which improved many measurements of physical health and prevented cognitive decline in aged mice.
Researchers Connect Cellular Markers to Physical Well-Being: In Aging Cell, a team of researchers has described how the health of skin fibroblasts relates to physical and functional ability.
Fixing Sugar Metabolism Shows Promise Against Dementia: Scientists have shown that aberrant metabolism of glycogen in neurons is linked to the accumulation of harmful tau protein. Caloric restriction, genetic interventions, and small molecules might help.
Five Hallmarks of Stem Cell Aging Proposed: In Cell Stem Cell, a trio of reviewers has proposed five hallmarks that are specific to the aging of stem cells.
Inflammaging Might Not Be Universal Across Populations: By comparing data from industrialized and non-industrialized societies, a new study calls into question some assumptions about the relationship between inflammation and aging.
Molecular Similarities Between Cigarette Smoking and Aging: Researchers have analyzed molecular patterns from different tissues obtained from over 700 people and learned that smoking acts as an aging accelerator.
Senolytics May Affect Inflammation-Related Cognitive Decline: Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell.
Scientists Successfully Edit Mitochondrial DNA: A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells.
How Blood-Brain Barrier Leaks Make Parkinson’s Worse: Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain.
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice: Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity.
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan: Psilocybin, a psychedelic compound found in hallucinogenic mushrooms, extends cellular and organismal lifespan, even when administered later in life.
Engineered Stem Cells Reduce Lung Fibrosis in Mice: In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model.
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial: Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in the former subgroup.
Vesicles From Antler Cells Restore Bone in Monkeys: Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques.
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice: Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s.
Organ-Specific Aging Analysis Reveals Disease Connections: A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific proteins found in plasma.
A Gene That Keeps Cells Under Control: Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation.
7,000 Steps a Day Are Enough for Most Benefits: A massive new meta-analysis confirms that 10,000 daily steps are not required for most of the health benefits of walking. Around 7,000 seems to be the sweet spot.
Fighting Osteoarthritis by Targeting Fatty Acids: In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production.
Rejuvenating Muscles in Mice With Senomorphic Treatment: A recent study investigated senescence in mouse and human skeletal muscle tissue, demonstrating that the antiviral drug maraviroc reduces senescence and improves muscle health in aged mice.
Senescent Cells, Osteoporosis, and Alzheimer’s Are Linked: Researchers publishing in Nature Aging have discovered how Alzheimer’s-related protein aggregates are also related to senescent cells and osteoporosis.
A high-fiber diet mimics aging-related signatures of caloric restriction in mammals: These results indicate that the high-fiber diet confers promising benefits for metabolic homeostasis and represents a valuable candidate for further health and aging studies.
Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis: Different exercise modalities provide domain-specific cognitive benefits in healthy older adults.
Differential associations of dietary inflammatory potential, antioxidant capacity, and Mediterranean diet adherence with biological aging:This study provides robust evidence that dietary pro-inflammatory potential, antioxidant capacity, and Mediterranean diet adherence exhibit independent and differential associations with biological aging.
Linking dietary creatine to DNA methylation-based predictors of mortality in individuals aged 50 and above: These findings highlight creatine’s potential as a modifiable dietary factor promoting healthy aging and longevity.
Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice: The detrimental effects of rapamycin on glucose metabolism in the context of voluntary exercise may be reduced by intermittent dosing.
GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study: These findings suggest that both GrimAge and GrimAge2 are effective epigenetic biomarkers for mortality risk prediction and may be valuable tools in future ageing-related research.
Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial): Plasmapheresis can rapidly change the levels of pro-inflammatory and other pro-aging molecules in the circulation. However, the selected protocol has not provided conclusive data supporting benefits. Based on epigenetic clock parameters, it may accelerate epigenetic aging.
Human umbilical cord-derived mesenchymal stromal cell exosomes ameliorate aging-associated skeletal muscle atrophy and dysfunction in SAMP10 mice: These findings indicate that hucMSC-Exos treatment ameliorated skeletal muscle atrophy and dysfunction via mitochondrial biogenesis, anti-apoptosis, and protein anabolism mechanisms.
A Machine-Learning Approach Identifies Rejuvenating Interventions in the Human Brain: These results demonstrate the platform’s ability to identify brain-rejuvenating interventions, offering potential treatments for neurodegenerative diseases.
Drug combination-wide association studies of cancer: These results demonstrate the platform’s ability to identify brain-rejuvenating interventions, offering potential treatments for neurodegenerative diseases.
Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis: These findings provide evidence-based guidance for clinical decision-making in anti-photoaging therapy.
Advancing Geroscience Research – A Scoping Review of Regulatory Environments for Gerotherapeutics: The researchers did not identify any geroscience specific regulatory frameworks but identified barriers to their development.
The impact of cannabis use on ageing and longevity: a systematic review of research insights: While preliminary research suggests intriguing possibilities, more studies are needed to solidify the link between cannabis use and healthy aging in humans.
Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice: These findings suggest that life-long oral nicotine consumption reprograms aging-associated metabolism through regulation of systemic sphingolipid homeostasis, conferring resilience against age-related motor decline.
News Nuggets
Chugai and Gero Enter Into Research and License Agreement: Chugai Pharmaceutical Co., Ltd. and Gero PTE. LTD, a Singapore-based biotechnology company, announced today that they have entered into a joint research and license agreement to develop novel therapies for age-related diseases.
Immortal Dragons Launches $40M Longevity Fund: Immortal Dragons, a purpose-driven longevity fund headquartered in Singapore, today announced its unique approach to investing in radical life extension technologies.
Coming Up
Madrid Set to Become the Longevity Capital of Europe: We are thrilled to announce the second edition of the International Longevity Summit (www.TransVisionMadrid.com) in beautiful Madrid after the major success in 2024.
