Category: News
A Million-Person Study Finds a Protective Metabolic Gene
August 14, 2026
A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest
A Drug Combination Fights Both Senescence and Cancer
August 13, 2026
In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer
The Thymus Hormone Thymulin Reduces Inflammaging in Mice
August 12, 2026
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made other cancer
Why Affecting Aging in Complex Organisms Is So Hard
August 11, 2026
A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging [1].
A New Target Against High Blood Pressure
August 10, 2026
Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own The authors
Wei-Wu He: People Should Become the CEOs of Their Own Health
August 7, 2026
Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – initially inspired high hopes. Several years and several
A New Transcriptomic Clock for Intervention Analysis
August 6, 2026
A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics The authors begin by discussing
Why Democratizing Rejuvenation Is an Economic Imperative
August 5, 2026
The cost of the broken sickcare system Modern medicine is effectively based on a reactive management approach. It typically waits for an acute organ failure, such as a heart attack,
Valine Restriction Increases Male Mouse Lifespan by 23%
August 4, 2026
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased
Rejuvenation Roundup July 2026
August 3, 2026
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here’s what’s happened
José Pedro Castro on Inflammation and Aging
July 31, 2026
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in
Short-Term Stresses May Undermine Clock Results
July 30, 2026
A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and
Montana’s Right-to-Try Law Enters a New Phase
July 28, 2026
Montana’s first experimental treatment review board has brought three longevity heavyweights into the state’s effort to expand access to experimental therapies. How much regulation is too much? Many people in
How the Immune System Makes Sun Damage Worse
July 27, 2026
In Aging Cell, researchers have published an explanation of how neutrophil extracellular traps (NETs) worsen UVB damage and how inhibiting them alleviated this damage in a mouse model. When defenders
NYC Woman Dead After Receiving a “Longevity Infusion”
July 24, 2026
According to the experts that we spoke to, the death, which followed an intravenous NAD⁺ infusion that went catastrophically wrong, underscores the risks of unproven treatments and the need for
A Million-Person Study Finds a Protective Metabolic Gene
August 14, 2026
A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1]. Longevity hidden in the genome For decades, aging researchers have hoped that
A Drug Combination Fights Both Senescence and Cancer
August 13, 2026
In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer Just as it does in mice, the incidence of cancer rises with age in people [1].
The Thymus Hormone Thymulin Reduces Inflammaging in Mice
August 12, 2026
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made other cancer treatments more effective [1]. The aging immune system Aging has a profound impact on the immune
Why Affecting Aging in Complex Organisms Is So Hard
August 11, 2026
A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging [1]. A problem of great complexity A familiar puzzle in geroscience is that while many of the
A New Target Against High Blood Pressure
August 10, 2026
Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own The authors begin their paper by discussing high blood pressure (hypertension), one of the most commonly known medical
Wei-Wu He: People Should Become the CEOs of Their Own Health
August 7, 2026
Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – initially inspired high hopes. Several years and several hundred million dollars later, however, the company entered what many people saw as a period of
A New Transcriptomic Clock for Intervention Analysis
August 6, 2026
A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics The authors begin by discussing the strengths and limitations of conventional methylation-based epigenetic clocks. They note that while such clocks have
Why Democratizing Rejuvenation Is an Economic Imperative
August 5, 2026
The cost of the broken sickcare system Modern medicine is effectively based on a reactive management approach. It typically waits for an acute organ failure, such as a heart attack, and then it deploys high-cost, non-curative interventions to manage the fallout. This is a flawed and
Valine Restriction Increases Male Mouse Lifespan by 23%
August 4, 2026
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased liver mitochondrial activity emerged as a leading clue. Protein composition matters The debates around how much
Rejuvenation Roundup July 2026
August 3, 2026
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here’s what’s happened in July. Interviews Gabriel Cian on Building the 2060 Longevity Ecosystem: In this follow-up interview, we
José Pedro Castro on Inflammation and Aging
July 31, 2026
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in Health at the University of Porto, has been studying inflammation and its crucial role in aging
Short-Term Stresses May Undermine Clock Results
July 30, 2026
A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability The authors make a clear distinction between technical and biological reliability. A technically reliable
Montana’s Right-to-Try Law Enters a New Phase
July 28, 2026
Montana’s first experimental treatment review board has brought three longevity heavyweights into the state’s effort to expand access to experimental therapies. How much regulation is too much? Many people in the longevity field will tell you that regulation is holding it back. Sensible oversight of novel
How the Immune System Makes Sun Damage Worse
July 27, 2026
In Aging Cell, researchers have published an explanation of how neutrophil extracellular traps (NETs) worsen UVB damage and how inhibiting them alleviated this damage in a mouse model. When defenders just make things worse Immune activation is a common response to damage, as the immune system
NYC Woman Dead After Receiving a “Longevity Infusion”
July 24, 2026
According to the experts that we spoke to, the death, which followed an intravenous NAD⁺ infusion that went catastrophically wrong, underscores the risks of unproven treatments and the need for rigorous longevity medicine. Earlier this week, Elizabeth Baron, a 27-year-old woman from New York City, died