Category: News
The Immune System Ages Differently in Men and Women
April 22, 2026
An investigation into the aging immune system identified age-related changes, including sex-dependent differences, in immune cell subpopulations and gene expression. In general, females showed greater age-related changes than males, including
Rapamycin Might Blunt Exercise Response in Humans
April 21, 2026
According to a new study, rapamycin probably interferes with exercise, blunting its effects in older human subjects. This result, however, might be specific to the particular protocol. Can they work
How Inflammaging Is Linked to Epigenetic Aging
April 20, 2026
A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying together two well-known aspects of aging
Engineered Stem Cells Become Lifelong Protein Factories
April 17, 2026
Researchers have genetically engineered blood stem cells to produce B cells that can churn out rare broad-action antibodies to fight HIV, malaria, and flu. This platform can also be used
Targeting an Appetite Hormone Receptor for Stronger Muscles
April 16, 2026
In Aging Cell, researchers have described how suppressing the ghrelin receptor improves muscle function and fights sarcopenia in older mice. An appetite hormone with negative effects Ghrelin has been well-documented
Vitamin C Alleviates Aging in Cynomolgus Monkeys
April 15, 2026
A recent study described a process called ferro-aging, in which iron accumulation leads to oxidative damage and cellular senescence. This process can be delayed by Vitamin C [1]. A two-faced
A Single Sauna Session Causes White Blood Cell Mobilization
April 14, 2026
A new study shows that hitting a sauna for 30 minutes causes a transient spike in the number of circulating white blood cells. The researchers suggest that this exercise-like effect
Why Fast-Cycling Skin Cells Decrease With Age
April 13, 2026
In Aging Cell, researchers have described how one dermal protein is related to maintaining the populations of fast-cycling skin cells and preserving skin integrity. Not all skin cells are the
Affecting a Signaling Pathway Alleviates Alzheimer’s in Mice
April 10, 2026
A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid β burden, improving cognitive abilities in
A Combination NAD+ Treatment Has Benefits for Mice
April 9, 2026
Researchers have found that simultaneously supplying NAD+ through NMN and reducing its loss through apigenin restores muscle function and bone structure to aged mice. A well-documented issue NAD+ is one
Life Bio’s Trial: Is the FDA Warming to Rejuvenation?
April 8, 2026
The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials this year, things might be changing
The Timing of Meals Matters for Biological Aging
April 8, 2026
A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of the first and last meals is
APOE4 Increases Neurons’ Excitability Before Symptoms Appear
April 7, 2026
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before
A Target for Ameliorating Post-Operative Delirium
April 6, 2026
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from
Insilico and Eli Lilly Announce a Major Collaboration
April 3, 2026
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software Earlier
The Immune System Ages Differently in Men and Women
April 22, 2026
An investigation into the aging immune system identified age-related changes, including sex-dependent differences, in immune cell subpopulations and gene expression. In general, females showed greater age-related changes than males, including greater changes in autoimmune gene expression [1]. Cell-by-cell analysis Aging results in changes to the function
Rapamycin Might Blunt Exercise Response in Humans
April 21, 2026
According to a new study, rapamycin probably interferes with exercise, blunting its effects in older human subjects. This result, however, might be specific to the particular protocol. Can they work together? Physical activity is one of the most potent pro-longevity interventions currently available [2]. Rapamycin is
How Inflammaging Is Linked to Epigenetic Aging
April 20, 2026
A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying together two well-known aspects of aging These researchers note that inflammatory problems have been repeatedly linked to aging, both in inflammaging and
Engineered Stem Cells Become Lifelong Protein Factories
April 17, 2026
Researchers have genetically engineered blood stem cells to produce B cells that can churn out rare broad-action antibodies to fight HIV, malaria, and flu. This platform can also be used to produce other essential proteins [1]. The rare gems Vaccination works because a small number of
Targeting an Appetite Hormone Receptor for Stronger Muscles
April 16, 2026
In Aging Cell, researchers have described how suppressing the ghrelin receptor improves muscle function and fights sarcopenia in older mice. An appetite hormone with negative effects Ghrelin has been well-documented as stimulating both appetite and growth [1]. However, this hormone, which increases with aging [2], has
Vitamin C Alleviates Aging in Cynomolgus Monkeys
April 15, 2026
A recent study described a process called ferro-aging, in which iron accumulation leads to oxidative damage and cellular senescence. This process can be delayed by Vitamin C [1]. A two-faced atom Iron, like many components of biological systems, has two faces. On the one hand, it’s
A Single Sauna Session Causes White Blood Cell Mobilization
April 14, 2026
A new study shows that hitting a sauna for 30 minutes causes a transient spike in the number of circulating white blood cells. The researchers suggest that this exercise-like effect might provide health benefits by improving immune surveillance [1]. How does a sauna do its trick?
Why Fast-Cycling Skin Cells Decrease With Age
April 13, 2026
In Aging Cell, researchers have described how one dermal protein is related to maintaining the populations of fast-cycling skin cells and preserving skin integrity. Not all skin cells are the same The outer layer of the skin (the epidermis) is naturally regenerated by two distinct populations
Affecting a Signaling Pathway Alleviates Alzheimer’s in Mice
April 10, 2026
A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid β burden, improving cognitive abilities in a mouse model of Alzheimer’s. Drugs affecting this pathway are already available [1]. The unusual suspect
A Combination NAD+ Treatment Has Benefits for Mice
April 9, 2026
Researchers have found that simultaneously supplying NAD+ through NMN and reducing its loss through apigenin restores muscle function and bone structure to aged mice. A well-documented issue NAD+ is one of the most well-documented compounds in biology, including within the context of aging. Precursor supplementation has
Life Bio’s Trial: Is the FDA Warming to Rejuvenation?
April 8, 2026
The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials this year, things might be changing there. If this technique works in resetting the biological age of the human eye, the entire
The Timing of Meals Matters for Biological Aging
April 8, 2026
A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of the first and last meals is associated with faster aging [1]. Finding the right patterns and rhythms Chrono-nutrition is an approach that
APOE4 Increases Neurons’ Excitability Before Symptoms Appear
April 7, 2026
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer’s disease begins long before symptoms appear, building silently for decades. The single strongest
A Target for Ameliorating Post-Operative Delirium
April 6, 2026
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from delirium after surgery [1], which rises to around half if the surgery is particularly invasive or
Insilico and Eli Lilly Announce a Major Collaboration
April 3, 2026
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software Earlier this week, the AI-driven drug discovery company Insilico Medicine announced a large-scale collaboration with the pharmaceutical