Category: News
A Small Molecule Regenerates Cartilage in Aged Mice
January 9, 2026
By inhibiting the aging-related enzyme 15-PGDH, scientists have shifted cartilage cells towards a healthier phenotype, leading to a significant improvement in a mouse model of osteoarthritis [1]. The hard-to-repair part
How Harmful Extracellular Vesicles Cause Brain Inflammation
January 8, 2026
In a paper published in Aging Cell, researchers have described how older cells send long interspersed nuclear element-1 (LINE-1) RNA to other cells in extracellular vesicles (EVs), spurring inflammation. Evil
Recombinant Human Protein Stops Neuronal Loss in Alzheimer’s
January 7, 2026
A recent study investigated biomarkers that can help monitor trajectories of Alzheimer’s disease-related molecular processes, such as neuronal cell death, and how patients respond to treatments. The authors reported that
Longevity Biotech in 2025: The Expert Roundup
January 6, 2026
How did the year 2025 turn out for longevity biotech? Was it surprising or more of the same? Exciting or disappointing? Was the progress fast-moving or excruciatingly slow? What should
A Single Gut Microbe Suppresses Weight Gain in Mice
January 5, 2026
Scientists have found that a single microbial species can blunt the negative effects of a high-fat diet due to the unique mix of lipids it produces [1]. They intend to
Rejuvenation Roundup December 2025
January 5, 2026
We’re closer to 2050 than to 2000, and technology is advancing apace; this includes technologies that help us stop aging in all its forms. Here’s the highlights of what’s been
How Multivitamins and Minerals Impact Health and Longevity
December 24, 2025
A recent review evaluated studies that included over 5.5 million participants to assess the impact of multivitamin and mineral supplements on different aspects of health [1]. A big market Multivitamin
Bacterium From Frogs Completely Destroys Colon Cancer
December 23, 2025
Scientists in Japan have discovered that multiple strains of bacteria taken from frogs, newts, and lizards can be effective against human colon cancer in a mouse model. One particular microbe
Researchers Find a Potential Target for Hearing Loss
December 23, 2025
In Aging Cell, researchers have identified bone marrow stromal antigen 2 (BST2) as a key protein in age-related hearing loss in a mouse model. Neural myelination is necessary for function
Producing Thymic Factors in the Liver Rejuvenates Immunity
December 22, 2025
A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function [1]. Bringing
Maximina Yun on the Wonders of the Axolotl
December 19, 2025
Dr. Maximina Yun, principal investigator at Chinese Institutes for Medical Research in Beijing (CIMR), studies some of the most amazing animals in the world: salamanders, a group of amphibians that
A Gene That Changes Function With Aging in Mice
December 18, 2025
In Nature Aging, researchers have discovered growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We
Analyzing the Quality of Preclinical Anti-Aging Research
December 17, 2025
Researchers have investigated the reporting quality of preclinical studies’ outcomes in anti-aging research. They analyzed how study quality changed over time, shortcomings in research, and the improvements that can be
Senescence Exacerbated by Mitochondrial RNA Leakage
December 16, 2025
Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver [1]. The
Targeting a Metabolic Regulator Reduces Fat in Mice
December 15, 2025
In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around
A Small Molecule Regenerates Cartilage in Aged Mice
January 9, 2026
By inhibiting the aging-related enzyme 15-PGDH, scientists have shifted cartilage cells towards a healthier phenotype, leading to a significant improvement in a mouse model of osteoarthritis [1]. The hard-to-repair part Articular cartilage (the smooth, load-bearing cartilage on the ends of bones) doesn’t repair well with age
How Harmful Extracellular Vesicles Cause Brain Inflammation
January 8, 2026
In a paper published in Aging Cell, researchers have described how older cells send long interspersed nuclear element-1 (LINE-1) RNA to other cells in extracellular vesicles (EVs), spurring inflammation. Evil EVs In the literature, EVs are often discussed in a therapeutic context, as they can be
Recombinant Human Protein Stops Neuronal Loss in Alzheimer’s
January 7, 2026
A recent study investigated biomarkers that can help monitor trajectories of Alzheimer’s disease-related molecular processes, such as neuronal cell death, and how patients respond to treatments. The authors reported that using biomarkers enabled them to gain insights into the molecular processes that contribute to improved cognition
Longevity Biotech in 2025: The Expert Roundup
January 6, 2026
How did the year 2025 turn out for longevity biotech? Was it surprising or more of the same? Exciting or disappointing? Was the progress fast-moving or excruciatingly slow? What should we expect in 2026? We asked five leading experts to weigh in. Where did longevity biotech
A Single Gut Microbe Suppresses Weight Gain in Mice
January 5, 2026
Scientists have found that a single microbial species can blunt the negative effects of a high-fat diet due to the unique mix of lipids it produces [1]. They intend to identify its specific lipids in future work. Good neighbors The billions of gut microbes that we
Rejuvenation Roundup December 2025
January 5, 2026
We’re closer to 2050 than to 2000, and technology is advancing apace; this includes technologies that help us stop aging in all its forms. Here’s the highlights of what’s been accomplished last month. Team and activities A Year of Rejuvenation Research and Journalism: Winter is in
How Multivitamins and Minerals Impact Health and Longevity
December 24, 2025
A recent review evaluated studies that included over 5.5 million participants to assess the impact of multivitamin and mineral supplements on different aspects of health [1]. A big market Multivitamin and mineral (MVM) supplements are widely used worldwide, and in the United States, around 40% of
Bacterium From Frogs Completely Destroys Colon Cancer
December 23, 2025
Scientists in Japan have discovered that multiple strains of bacteria taken from frogs, newts, and lizards can be effective against human colon cancer in a mouse model. One particular microbe achieved a perfect response rate and survival [1]. Bacteria against cancer Recent research has illuminated the
Researchers Find a Potential Target for Hearing Loss
December 23, 2025
In Aging Cell, researchers have identified bone marrow stromal antigen 2 (BST2) as a key protein in age-related hearing loss in a mouse model. Neural myelination is necessary for function Demyelination, the loss of neurons’ protective sheaths, is known to be fundamental in multiple serious neurological
Producing Thymic Factors in the Liver Rejuvenates Immunity
December 22, 2025
A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function [1]. Bringing back the Ts Immunosenescence, the gradual deterioration of the immune system, is a central aspect of
Maximina Yun on the Wonders of the Axolotl
December 19, 2025
Dr. Maximina Yun, principal investigator at Chinese Institutes for Medical Research in Beijing (CIMR), studies some of the most amazing animals in the world: salamanders, a group of amphibians that includes newts and species such as the universally loved axolotl. On top of being cute, salamanders
A Gene That Changes Function With Aging in Mice
December 18, 2025
In Nature Aging, researchers have discovered growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We have recently reported on a potential treatment for visceral fat, as this kind of fat is
Analyzing the Quality of Preclinical Anti-Aging Research
December 17, 2025
Researchers have investigated the reporting quality of preclinical studies’ outcomes in anti-aging research. They analyzed how study quality changed over time, shortcomings in research, and the improvements that can be made in the future in order to yield as many valuable insights as possible [1]. The
Senescence Exacerbated by Mitochondrial RNA Leakage
December 16, 2025
Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver [1]. The new target The increasing abundance of senescent cells with age has been linked to numerous diseases
Targeting a Metabolic Regulator Reduces Fat in Mice
December 15, 2025
In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around the body is subcutaneous fat. While this kind of fat is obviously not healthy to have