Category: News
In ALS, Microglia Eat Living Neurons, Mistaking Them for Dead
August 21, 2026
A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling
How Old Fat Cells Trigger Inflammation and Raise Risks
August 20, 2026
Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in
GenBio Launches a “Virtual Cell” AI Model
August 18, 2026
This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to
How Senescence Spreads Between Brain Cells
August 17, 2026
Researchers have gone into deep detail regarding how each of five senescent brain cell types expresses and receives factors that encourage other cells to become senescent. The contagion of age
A Million-Person Study Finds a Protective Metabolic Gene
August 14, 2026
A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest
A Drug Combination Fights Both Senescence and Cancer
August 13, 2026
In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer
The Thymus Hormone Thymulin Reduces Inflammaging in Mice
August 12, 2026
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made other cancer
Why Affecting Aging in Complex Organisms Is So Hard
August 11, 2026
A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging [1].
A New Target Against High Blood Pressure
August 10, 2026
Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own The authors
Wei-Wu He: People Should Become the CEOs of Their Own Health
August 7, 2026
Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – initially inspired high hopes. Several years and several
A New Transcriptomic Clock for Intervention Analysis
August 6, 2026
A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics The authors begin by discussing
Why Democratizing Rejuvenation Is an Economic Imperative
August 5, 2026
Worldwide healthcare faces an unsustainable situation. We spend trillions managing the late-stage effects of biological aging, yet routinely overlook the underlying causes that drive them. Driven by an aging society,
Valine Restriction Increases Male Mouse Lifespan by 23%
August 4, 2026
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased
Rejuvenation Roundup July 2026
August 3, 2026
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here’s what’s happened
José Pedro Castro on Inflammation and Aging
July 31, 2026
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in
In ALS, Microglia Eat Living Neurons, Mistaking Them for Dead
August 21, 2026
A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1]. The living dead Amyotrophic lateral sclerosis (ALS), an age-related neurodegenerative disease, is characterized by the
How Old Fat Cells Trigger Inflammation and Raise Risks
August 20, 2026
Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Too much of a regulator leads to dysregulation This paper introduces itself with
GenBio Launches a “Virtual Cell” AI Model
August 18, 2026
This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to successive perturbations, potentially transforming biological research. Living in a simulation Simulating a living organism on a
How Senescence Spreads Between Brain Cells
August 17, 2026
Researchers have gone into deep detail regarding how each of five senescent brain cell types expresses and receives factors that encourage other cells to become senescent. The contagion of age This paper revolves around paracrine senescence: SASP factors being emitted by primary senescent cells to drive
A Million-Person Study Finds a Protective Metabolic Gene
August 14, 2026
A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1]. Longevity hidden in the genome For decades, aging researchers have hoped that
A Drug Combination Fights Both Senescence and Cancer
August 13, 2026
In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer Just as it does in mice, the incidence of cancer rises with age in people [1].
The Thymus Hormone Thymulin Reduces Inflammaging in Mice
August 12, 2026
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made other cancer treatments more effective [1]. The aging immune system Aging has a profound impact on the immune
Why Affecting Aging in Complex Organisms Is So Hard
August 11, 2026
A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging [1]. A problem of great complexity A familiar puzzle in geroscience is that while many of the
A New Target Against High Blood Pressure
August 10, 2026
Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own The authors begin their paper by discussing high blood pressure (hypertension), one of the most commonly known medical
Wei-Wu He: People Should Become the CEOs of Their Own Health
August 7, 2026
Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – initially inspired high hopes. Several years and several hundred million dollars later, however, the company entered what many people saw as a period of
A New Transcriptomic Clock for Intervention Analysis
August 6, 2026
A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics The authors begin by discussing the strengths and limitations of conventional methylation-based epigenetic clocks. They note that while such clocks have
Why Democratizing Rejuvenation Is an Economic Imperative
August 5, 2026
Worldwide healthcare faces an unsustainable situation. We spend trillions managing the late-stage effects of biological aging, yet routinely overlook the underlying causes that drive them. Driven by an aging society, the financial burdens of treating diabetes, dementia, and heart disease are pushing Social Security and Medicare
Valine Restriction Increases Male Mouse Lifespan by 23%
August 4, 2026
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased liver mitochondrial activity emerged as a leading clue. Protein composition matters The debates around how much
Rejuvenation Roundup July 2026
August 3, 2026
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here’s what’s happened in July. Interviews Gabriel Cian on Building the 2060 Longevity Ecosystem: In this follow-up interview, we
José Pedro Castro on Inflammation and Aging
July 31, 2026
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in Health at the University of Porto, has been studying inflammation and its crucial role in aging