Category: News
A Combination NAD+ Treatment Has Benefits for Mice
April 9, 2026
Researchers have found that simultaneously supplying NAD+ through NMN and reducing its loss through apigenin restores muscle function and bone structure to aged mice. A well-documented issue NAD+ is one
Life Bio’s Trial: Is the FDA Warming to Rejuvenation?
April 8, 2026
The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials this year, things might be changing
The Timing of Meals Matters for Biological Aging
April 8, 2026
A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of the first and last meals is
APOE4 Increases Neurons’ Excitability Before Symptoms Appear
April 7, 2026
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before
A Target for Ameliorating Post-Operative Delirium
April 6, 2026
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from
Insilico and Eli Lilly Announce a Major Collaboration
April 3, 2026
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software Earlier
How an Enzyme’s Depletion Makes Fat Worse
April 2, 2026
In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat
Becoming Well-Fed and Sedentary Accelerates Penguin Aging
April 1, 2026
A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated aging and changes
Rejuvenation Roundup March 2026
April 1, 2026
For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let’s see what’s been done last month to rejuvenate animals and people. Team and Activities Support the
Modified Immune Cells Target Cancer’s Metabolic Signature
March 31, 2026
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune cells
How a Growth Factor and SIRT1 Might Combat Disc Degeneration
March 30, 2026
Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of lower back problems
Mitochondria Delivery Method Rescues Parkinson’s in Mice
March 27, 2026
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. The delivery problem Mitochondrial
Cellular Senescence and Senotherapeutics: The Expert Roundup
March 26, 2026
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in longevity medicine. Senescent
Two Polyunsaturated Lipids Demonstrate Senolytic Activity
March 25, 2026
A new study identified two polyunsaturated fatty acids, α-eleostearic acid (α-ESA) and α-ESA methyl ester (α-ESA-me), that showed senolytic activity in cell cultures and a mouse model [1]. An anti-aging strategy
In Vivo Created CAR T Cells Eliminate Tumors in Mice
March 24, 2026
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher efficacy across three
A Combination NAD+ Treatment Has Benefits for Mice
April 9, 2026
Researchers have found that simultaneously supplying NAD+ through NMN and reducing its loss through apigenin restores muscle function and bone structure to aged mice. A well-documented issue NAD+ is one of the most well-documented compounds in biology, including within the context of aging. Precursor supplementation has
Life Bio’s Trial: Is the FDA Warming to Rejuvenation?
April 8, 2026
The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials this year, things might be changing there. If this technique works in resetting the biological age of the human eye, the entire
The Timing of Meals Matters for Biological Aging
April 8, 2026
A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of the first and last meals is associated with faster aging [1]. Finding the right patterns and rhythms Chrono-nutrition is an approach that
APOE4 Increases Neurons’ Excitability Before Symptoms Appear
April 7, 2026
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer’s disease begins long before symptoms appear, building silently for decades. The single strongest
A Target for Ameliorating Post-Operative Delirium
April 6, 2026
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from delirium after surgery [1], which rises to around half if the surgery is particularly invasive or
Insilico and Eli Lilly Announce a Major Collaboration
April 3, 2026
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software Earlier this week, the AI-driven drug discovery company Insilico Medicine announced a large-scale collaboration with the pharmaceutical
How an Enzyme’s Depletion Makes Fat Worse
April 2, 2026
In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat.
Becoming Well-Fed and Sedentary Accelerates Penguin Aging
April 1, 2026
A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated aging and changes in metabolic pathways [1]. A unique model system A sedentary lifestyle and obesity are linked to
Rejuvenation Roundup March 2026
April 1, 2026
For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let’s see what’s been done last month to rejuvenate animals and people. Team and Activities Support the Human Ageing Genomic Resources: João Pedro de Magalhães has launched a fundraiser to help maintain this
Modified Immune Cells Target Cancer’s Metabolic Signature
March 31, 2026
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune cells into the tumor? One of the central challenges in cancer immunotherapy is getting the right immune
How a Growth Factor and SIRT1 Might Combat Disc Degeneration
March 30, 2026
Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of lower back problems Intervertebral disc degeneration (IDD) is one of the core reasons for lower back pain in older
Mitochondria Delivery Method Rescues Parkinson’s in Mice
March 27, 2026
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. The delivery problem Mitochondrial diseases are a diverse group of disorders that arise when mitochondria malfunction. They are often caused
Cellular Senescence and Senotherapeutics: The Expert Roundup
March 26, 2026
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in longevity medicine. Senescent cells actually serve important roles in development, wound healing, and cancer prevention, but as they accumulate
Two Polyunsaturated Lipids Demonstrate Senolytic Activity
March 25, 2026
A new study identified two polyunsaturated fatty acids, α-eleostearic acid (α-ESA) and α-ESA methyl ester (α-ESA-me), that showed senolytic activity in cell cultures and a mouse model [1]. An anti-aging strategy Cellular senescence is one of the most critical aging-related processes. Senescent cells, which accumulate with age,
In Vivo Created CAR T Cells Eliminate Tumors in Mice
March 24, 2026
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher efficacy across three cancer types, including a solid tumor [1]. CAR T therapies: promising but imperfect Ideally, T cells,