Category: News
Calcium Mishandling Contributes to Muscle Loss
September 10, 2026
Researchers have discovered and explained how calcium mishandling in muscle cells leads to long-term muscle weakness in older people. Calcium is not just for bones Skeletal muscle cells use calcium
Comparing the Responsiveness of Epigenetic Aging Biomarkers
September 9, 2026
In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Waiting too long Testing lifespan-extending interventions in humans
Late-Life GLP-1 Treatment Increases Lifespan in Female Mice
September 8, 2026
In a new study, semaglutide given late in life increased median lifespan in female mice by more than 12% and improved various health markers. Semaglutide’s effect possibly went beyond caloric
Mice With Growth Hormone Halted in Middle Age Live Longer
September 7, 2026
Researchers publishing in Aging Cell have described how stopping growth hormone receptor production in midlife significantly lengthens the lives of mice. Growth but diabetes Growth hormone affects the metabolism of
The Last Generation to Die: Interview With Tim Maupin
September 3, 2026
Filmmaker Tim Maupin has spent a number of years developing The Last Generation to Die, a near-future film about what happens when the first true rejuvenation technologies arrive and who
Rejuvenation Roundup August 2026
September 1, 2026
Properly untangling aging means untangling its various counterbalances, sometimes on the individual level. Here’s what’s been investigated this month. Interviews Wei-Wu He: People Should Become the CEOs of Their Own
A Mechanistic Explanation for SIRT1’s Effects
August 31, 2026
Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. When DNA modifies itself
Michael Snyder: We Need to Track Health, Not Disease
August 28, 2026
Michael Snyder, Director of the Center for Genomics and Personalized Medicine at Stanford University, is obsessed with health-tracking wearables. During our interview, he wore four wrist-worn devices – watches and
Why Turning Off Cancer Genes Doesn’t Always Work
August 27, 2026
A recent study has examined whether senescence might allow cancer cells to survive oncogene withdrawal and become even more dangerous [1]. Some blocking techniques are temporary Many cancers depend heavily
Short, Intense Exercise Elicits Beneficial Metabolic Changes
August 26, 2026
A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic
A Tougher Extracellular Matrix Strengthens Tendons in Rats
August 24, 2026
Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Tendon injuries in older people Previous research has
In ALS, Microglia Eat Living Neurons, Mistaking Them for Dead
August 21, 2026
A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling
How Old Fat Cells Trigger Inflammation and Raise Risks
August 20, 2026
Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in
GenBio Launches a “Virtual Cell” AI Model
August 18, 2026
This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to
How Senescence Spreads Between Brain Cells
August 17, 2026
Researchers have gone into deep detail regarding how each of five senescent brain cell types expresses and receives factors that encourage other cells to become senescent. The contagion of age
Calcium Mishandling Contributes to Muscle Loss
September 10, 2026
Researchers have discovered and explained how calcium mishandling in muscle cells leads to long-term muscle weakness in older people. Calcium is not just for bones Skeletal muscle cells use calcium ions to control how and when they contract. This activity is modulated by CaMKII, a protein
Comparing the Responsiveness of Epigenetic Aging Biomarkers
September 9, 2026
In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Waiting too long Testing lifespan-extending interventions in humans has a major problem: it can take many years, or even decades, to see results. Nobody
Late-Life GLP-1 Treatment Increases Lifespan in Female Mice
September 8, 2026
In a new study, semaglutide given late in life increased median lifespan in female mice by more than 12% and improved various health markers. Semaglutide’s effect possibly went beyond caloric restriction [1]. Old mice, new drugs GLP-1 receptor agonists, which act on a hormone that regulates
Mice With Growth Hormone Halted in Middle Age Live Longer
September 7, 2026
Researchers publishing in Aging Cell have described how stopping growth hormone receptor production in midlife significantly lengthens the lives of mice. Growth but diabetes Growth hormone affects the metabolism of fats (lipids), increasing the levels of circulating fatty acids while increasing insulin-like growth factor 1 (IGF-1)
The Last Generation to Die: Interview With Tim Maupin
September 3, 2026
Filmmaker Tim Maupin has spent a number of years developing The Last Generation to Die, a near-future film about what happens when the first true rejuvenation technologies arrive and who gets left behind. The project has now reached the top 65 of the Future Vision XPrize,
Rejuvenation Roundup August 2026
September 1, 2026
Properly untangling aging means untangling its various counterbalances, sometimes on the individual level. Here’s what’s been investigated this month. Interviews Wei-Wu He: People Should Become the CEOs of Their Own Health: Wei-Wu He is an unusual combination of scientist and businessman, and his current company focuses
A Mechanistic Explanation for SIRT1’s Effects
August 31, 2026
Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. When DNA modifies itself Long interspersed elements-1 (LINE-1) have existed in organisms’ genomes, including our own, for well over a
Michael Snyder: We Need to Track Health, Not Disease
August 28, 2026
Michael Snyder, Director of the Center for Genomics and Personalized Medicine at Stanford University, is obsessed with health-tracking wearables. During our interview, he wore four wrist-worn devices – watches and bands – and two rings. He is convinced that these small but powerful gadgets will help
Why Turning Off Cancer Genes Doesn’t Always Work
August 27, 2026
A recent study has examined whether senescence might allow cancer cells to survive oncogene withdrawal and become even more dangerous [1]. Some blocking techniques are temporary Many cancers depend heavily on a particular oncogenic signal to maintain their growth. Drugs that block these drivers can, therefore,
Short, Intense Exercise Elicits Beneficial Metabolic Changes
August 26, 2026
A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. long and moderate Exercise is a well-known lifestyle factor
A Tougher Extracellular Matrix Strengthens Tendons in Rats
August 24, 2026
Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Tendon injuries in older people Previous research has found that, like with many other injuries, tendon injuries have an age-related component. The tendons of
In ALS, Microglia Eat Living Neurons, Mistaking Them for Dead
August 21, 2026
A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1]. The living dead Amyotrophic lateral sclerosis (ALS), an age-related neurodegenerative disease, is characterized by the
How Old Fat Cells Trigger Inflammation and Raise Risks
August 20, 2026
Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Too much of a regulator leads to dysregulation This paper introduces itself with
GenBio Launches a “Virtual Cell” AI Model
August 18, 2026
This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to successive perturbations, potentially transforming biological research. Living in a simulation Simulating a living organism on a
How Senescence Spreads Between Brain Cells
August 17, 2026
Researchers have gone into deep detail regarding how each of five senescent brain cell types expresses and receives factors that encourage other cells to become senescent. The contagion of age This paper revolves around paracrine senescence: SASP factors being emitted by primary senescent cells to drive