Category: News
The Thalion Initiative: A New Non-Profit With Big Ambitions
June 2, 2026
The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires understanding it first. With
Rejuvenation Roundup May 2026
June 1, 2026
Approaches that modify the processes of aging at their roots have gone well beyond basic research and into therapies intended for the clinic within the next few years. Here’s how
Harvard Publishes a Longevity Report for the General Public
May 29, 2026
The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age and entering the mainstream.
A Better Algorithm for Predicting How Cells Behave
May 28, 2026
In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells’ gene expression will respond to interventions. The
Early Cancer Cells Change Their Surroundings to Form Tumors
May 28, 2026
Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. This can inform future early-stage cancer therapies [1]. Cancer is a
Cardiovascular Health During the Menopausal Transition
May 27, 2026
A recent study compared premenopausal, perimenopausal, and postmenopausal women’s cardiovascular health. Perimenopausal women had about twice the odds of having a poor overall score when compared with premenopausal women, after
Tau Protein Is Crucial for Encoding Long-Term Memory
May 26, 2026
Scientists have uncovered an unexpected function of the tau protein, which is mostly known for its role in Alzheimer’s and related disorders: helping encode long-term memory. This can inform novel
How Omega-3 Fatty Acids May Alleviate Kidney Disease
May 25, 2026
Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Previous mixed results Several clinical trials have found
Mitochondrial Aging Linked to Losing Crucial Membrane Lipid
May 22, 2026
Scientists have found that the levels of phosphatidylcholine, the most abundant lipid in mitochondrial membranes, decline with age, driving mitochondrial aging in worms and possibly humans. Supplementing the lipid helped
How an Oxidative Stress Regulator Makes Cataracts Worse
May 21, 2026
Researchers have outlined a key receptor and protein involved in the formation of cataracts, paving the way for potential treatments targeting them. Oxidative stress and cataracts are closely related Cataracts,
Untangling Cellular Senescence at Its Roots
May 20, 2026
In Aging Cell, researchers have described the differences between primary and secondary senescent cells, comparing radiation-induced senescence to senescence induced by the senescence-associated secretory phenotype (SASP). Heterogeneity on top of
CRISPR-Based System Targets RNA and Kills Cells on Demand
May 19, 2026
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assassination of cells CRISPR-based
Developing a Drug To Reverse Heart Disease
May 18, 2026
We have spoken with Reason from Repair Biotechnologies about his company’s lead candidate, REP-0004, a drug targeting the liver to reduce excess intracellular free cholesterol. The FDA has granted Repair
New mRNA Therapy Destroys Cancer by Improving T Cell Priming
May 15, 2026
Scientists have found a way to drastically ramp up mouse immune responses to cancer along with flu and COVID-19 [1]. How to wake up the immune system Modern cancer immunotherapies
Matthew O’Connor on Cyclarity’s Successful Phase 1 Trial
May 14, 2026
Most cardiovascular trials focus on lowering LDL cholesterol or reducing inflammation to slow disease progression. UDP-003 targets the root cause: toxic 7-ketocholesterol (7KC) inside macrophages and soft plaques. It is
The Thalion Initiative: A New Non-Profit With Big Ambitions
June 2, 2026
The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires understanding it first. With VCs looking for clinical successes and state funding drying up for many projects, some enthusiasts are
Rejuvenation Roundup May 2026
June 1, 2026
Approaches that modify the processes of aging at their roots have gone well beyond basic research and into therapies intended for the clinic within the next few years. Here’s how the field has advanced in May. Team and activities The Longevity Investor Network Looks Back at
Harvard Publishes a Longevity Report for the General Public
May 29, 2026
The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age and entering the mainstream. People do want to live longer From time to time, Harvard Health Publishing issues Special Health
A Better Algorithm for Predicting How Cells Behave
May 28, 2026
In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells’ gene expression will respond to interventions. The need for prediction Simulating biological processes on a computer is an incredibly difficult task. While advanced
Early Cancer Cells Change Their Surroundings to Form Tumors
May 28, 2026
Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. This can inform future early-stage cancer therapies [1]. Cancer is a disease of aging. With the exception of childhood cancers, most of which stem from inherited genetic
Cardiovascular Health During the Menopausal Transition
May 27, 2026
A recent study compared premenopausal, perimenopausal, and postmenopausal women’s cardiovascular health. Perimenopausal women had about twice the odds of having a poor overall score when compared with premenopausal women, after adjusting for age [1]. Menopausal health decline The menopausal transition, and the associated changes in hormonal
Tau Protein Is Crucial for Encoding Long-Term Memory
May 26, 2026
Scientists have uncovered an unexpected function of the tau protein, which is mostly known for its role in Alzheimer’s and related disorders: helping encode long-term memory. This can inform novel approaches that target tau [1]. In sickness and in health Tau is a protein found mainly
How Omega-3 Fatty Acids May Alleviate Kidney Disease
May 25, 2026
Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Previous mixed results Several clinical trials have found that taking omega-3 PUFAs has benefits for older people. One study found that it reduces the
Mitochondrial Aging Linked to Losing Crucial Membrane Lipid
May 22, 2026
Scientists have found that the levels of phosphatidylcholine, the most abundant lipid in mitochondrial membranes, decline with age, driving mitochondrial aging in worms and possibly humans. Supplementing the lipid helped in an in vitro experiment [1]. What drives mitochondrial aging? Mitochondria are the cell’s energy-generating organelles,
How an Oxidative Stress Regulator Makes Cataracts Worse
May 21, 2026
Researchers have outlined a key receptor and protein involved in the formation of cataracts, paving the way for potential treatments targeting them. Oxidative stress and cataracts are closely related Cataracts, which cloud the lenses of the eye, are one of the most common sources of age-related
Untangling Cellular Senescence at Its Roots
May 20, 2026
In Aging Cell, researchers have described the differences between primary and secondary senescent cells, comparing radiation-induced senescence to senescence induced by the senescence-associated secretory phenotype (SASP). Heterogeneity on top of heterogeneity It is well-known that senescent cells are highly heterogenous [1]; senescent cells from one tissue
CRISPR-Based System Targets RNA and Kills Cells on Demand
May 19, 2026
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assassination of cells CRISPR-based systems work by cutting or changing DNA at a particular spot, an ability that can be
Developing a Drug To Reverse Heart Disease
May 18, 2026
We have spoken with Reason from Repair Biotechnologies about his company’s lead candidate, REP-0004, a drug targeting the liver to reduce excess intracellular free cholesterol. The FDA has granted Repair Bio an orphan drug indication, and the company is aiming for clinical trials by mid-2027. Our
New mRNA Therapy Destroys Cancer by Improving T Cell Priming
May 15, 2026
Scientists have found a way to drastically ramp up mouse immune responses to cancer along with flu and COVID-19 [1]. How to wake up the immune system Modern cancer immunotherapies only work for a minority of patients. The reason, broadly, is that many tumors are immunologically
Matthew O’Connor on Cyclarity’s Successful Phase 1 Trial
May 14, 2026
Most cardiovascular trials focus on lowering LDL cholesterol or reducing inflammation to slow disease progression. UDP-003 targets the root cause: toxic 7-ketocholesterol (7KC) inside macrophages and soft plaques. It is designed to convert bloated foam cells back into healthy macrophages that can actively clear the hard