Category: News
Why Democratizing Rejuvenation Is an Economic Imperative
August 5, 2026
The cost of the broken sickcare system Modern medicine is effectively based on a reactive management approach. It typically waits for an acute organ failure, such as a heart attack,
Valine Restriction Increases Male Mouse Lifespan by 23%
August 4, 2026
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased
Rejuvenation Roundup July 2026
August 3, 2026
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here’s what’s happened
José Pedro Castro on Inflammation and Aging
July 31, 2026
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in
Short-Term Stresses May Undermine Clock Results
July 30, 2026
A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and
Montana’s Right-to-Try Law Enters a New Phase
July 28, 2026
Montana’s first experimental treatment review board has brought three longevity heavyweights into the state’s effort to expand access to experimental therapies. How much regulation is too much? Many people in
How the Immune System Makes Sun Damage Worse
July 27, 2026
In Aging Cell, researchers have published an explanation of how neutrophil extracellular traps (NETs) worsen UVB damage and how inhibiting them alleviated this damage in a mouse model. When defenders
NYC Woman Dead After Receiving a “Longevity Infusion”
July 24, 2026
According to the experts that we spoke to, the death, which followed an intravenous NAD⁺ infusion that went catastrophically wrong, underscores the risks of unproven treatments and the need for
More Autophagy Reduces Toxin-Induced Kidney Failure in Mice
July 23, 2026
Autophagy, which increases in younger mice under toxic stress, does not increase in older mice and leaves them susceptible to acute kidney injury (AKI). Increasing autophagic flux by targeting a
The Progress and Future of Biological Aging Clocks
July 22, 2026
A recent review discusses the development of biological aging clocks, their capabilities and limitations, the discoveries they enabled, and possible future developments in this area [1]. How do we measure
Regular Training Erases Parts of Muscle Aging Signature
July 21, 2026
A new study suggests that regular planned exercise, not just being generally active, protects against certain aspects of muscle aging [1]. Are trained muscles younger? With age, skeletal muscles lose
Gabriel Cian on Building the 2060 Longevity Ecosystem
July 21, 2026
In this follow-up interview, we speak with Gabriel Cian about how the 2060 ecosystem has evolved since last year’s Forum, what he learned from the first edition, and how he
Exosomes From Stem Cells Fight Liver Disease in Mice
July 20, 2026
Researchers have described a method of using exosomes derived from mesenchymal stem cells (MSCs) to fight harmful metabolic changes in the liver. Another look at exosomes This is far from
Engineered Enzyme Reverses Age-Related Protein Damage
July 17, 2026
Scientists have engineered an enzyme that removes an advanced glycation end product (AGE) from proteins. This type of age-related modification, which affects protein function and can trigger inflammation, has previously
Activating a Key Receptor Fights Thymic Involution in Mice
July 16, 2026
Publishing in Aging Cell, researchers have devised a way to delay the aging of the thymus by targeting GPR40, a key receptor in its epithelial cells. The organ that involutes
Why Democratizing Rejuvenation Is an Economic Imperative
August 5, 2026
The cost of the broken sickcare system Modern medicine is effectively based on a reactive management approach. It typically waits for an acute organ failure, such as a heart attack, and then it deploys high-cost, non-curative interventions to manage the fallout. This is a flawed and
Valine Restriction Increases Male Mouse Lifespan by 23%
August 4, 2026
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased liver mitochondrial activity emerged as a leading clue. Protein composition matters The debates around how much
Rejuvenation Roundup July 2026
August 3, 2026
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here’s what’s happened in July. Interviews Gabriel Cian on Building the 2060 Longevity Ecosystem: In this follow-up interview, we
José Pedro Castro on Inflammation and Aging
July 31, 2026
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in Health at the University of Porto, has been studying inflammation and its crucial role in aging
Short-Term Stresses May Undermine Clock Results
July 30, 2026
A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability The authors make a clear distinction between technical and biological reliability. A technically reliable
Montana’s Right-to-Try Law Enters a New Phase
July 28, 2026
Montana’s first experimental treatment review board has brought three longevity heavyweights into the state’s effort to expand access to experimental therapies. How much regulation is too much? Many people in the longevity field will tell you that regulation is holding it back. Sensible oversight of novel
How the Immune System Makes Sun Damage Worse
July 27, 2026
In Aging Cell, researchers have published an explanation of how neutrophil extracellular traps (NETs) worsen UVB damage and how inhibiting them alleviated this damage in a mouse model. When defenders just make things worse Immune activation is a common response to damage, as the immune system
NYC Woman Dead After Receiving a “Longevity Infusion”
July 24, 2026
According to the experts that we spoke to, the death, which followed an intravenous NAD⁺ infusion that went catastrophically wrong, underscores the risks of unproven treatments and the need for rigorous longevity medicine. Earlier this week, Elizabeth Baron, a 27-year-old woman from New York City, died
More Autophagy Reduces Toxin-Induced Kidney Failure in Mice
July 23, 2026
Autophagy, which increases in younger mice under toxic stress, does not increase in older mice and leaves them susceptible to acute kidney injury (AKI). Increasing autophagic flux by targeting a key molecule, transcription factor EB (TFEB), alleviates some of this damage. An acute disease with lasting
The Progress and Future of Biological Aging Clocks
July 22, 2026
A recent review discusses the development of biological aging clocks, their capabilities and limitations, the discoveries they enabled, and possible future developments in this area [1]. How do we measure aging? Developments in science and technology have allowed researchers to move beyond speculation and philosophical debates
Regular Training Erases Parts of Muscle Aging Signature
July 21, 2026
A new study suggests that regular planned exercise, not just being generally active, protects against certain aspects of muscle aging [1]. Are trained muscles younger? With age, skeletal muscles lose strength, metabolic flexibility, and mitochondrial capacity. While regular exercise slows many aspects of functional aging [2],
Gabriel Cian on Building the 2060 Longevity Ecosystem
July 21, 2026
In this follow-up interview, we speak with Gabriel Cian about how the 2060 ecosystem has evolved since last year’s Forum, what he learned from the first edition, and how he is thinking about investment, scientific credibility, health optimization, policy, and the future of longevity in Europe.
Exosomes From Stem Cells Fight Liver Disease in Mice
July 20, 2026
Researchers have described a method of using exosomes derived from mesenchymal stem cells (MSCs) to fight harmful metabolic changes in the liver. Another look at exosomes This is far from the first attempt at using MSC-derived exosomes, particularly exosomes derived from MSCs originally taken from human
Engineered Enzyme Reverses Age-Related Protein Damage
July 17, 2026
Scientists have engineered an enzyme that removes an advanced glycation end product (AGE) from proteins. This type of age-related modification, which affects protein function and can trigger inflammation, has previously been considered extremely hard to reverse [1]. Can we rejuvenate proteins? Many proteins are continually broken
Activating a Key Receptor Fights Thymic Involution in Mice
July 16, 2026
Publishing in Aging Cell, researchers have devised a way to delay the aging of the thymus by targeting GPR40, a key receptor in its epithelial cells. The organ that involutes The thymus trains a certain subset of immune cells, which are named T cells due to