We Are Building a Future Free of Age-Related Disease

Lifespan  Research Institute  is focused on strategically driving forward science to extend healthy human lifespan – through advocacy, ecosystem building, and director support of cutting edge research into the root causes of aging.

Age-related diseases such as Alzheimer’s, heart disease, and cancer,  cause untold harm –  both in terms of personal suffering and socio-economic effects. Like treating the trunk of a tree as opposed to its various branches, it is a much more effective strategy to treat age-related maladies by addressing the process that is at the heart of them all, the aging process itself.

Discover the science behind our strategies to extend a healthy lifespan.

Training a new generation of scientists to tackle the roots of age-related disease.

Our investor network supports companies developing interventions that target aging.

We uniquely engage the public with large-scale media and crowdfunding initiatives. 

Addressing the Root Causes of Aging is a Much Better Way to Fight Disease​

Healthy Life Expectancy and Total Life Expectancy Gained

Cure Cancer

2.5 Years

3 Years

Cure Heart Disease

4 Years

5 Years

Improved Aging

25+ Years

Outreach Highlights -

SENS Research Foundation is seeking volunteers for blood donations.

Your participation will help advance our understanding of the immune system and mitochondrial biology in aging.

SENS Research Foundation, dedicated to advancing rejuvenation biotechnologies, has recently begun subleasing lab space in the heart of Silicon Valley.

The sublease includes access to an extensive list of laboratory equipment, a break room, conference rooms, and much more.

Research Highlights -

Watch SRF Science Writer Michael Rae‘s presentation Damage Repair is the Superior Approach Against Aging.

SRF is a proud sponsor of the Phaedon Institute’s Seno-Therapeutics Summit 2023. Dr. Amit Sharma spoke at the Summit – his presentation was entitled, “Next-generation Senotherapeutics: From harnessing the immune system to targeting newer vulnerabilities of senescent cells.

The summit was hosted by the Buck Institute For Research On Aging in Novato, CA. Entitled Seno-Therapeutics: Past, Present & Future of the Science of Cellular Senescence and Therapeutics, the summit was held November 7-8, 2023.

Education Highlights -

Thank you to our Director of Academic Affairs, Dr. Lilli Fishman, for participating in the National Academies of Sciences, Engineering, and Medicine GUIRR unit’s Industry Forum.

Thank you to  Kriti Bhardwaj and Kartik Sundaram for presenting their final presentation as part of the 2024 SRF Post-baccalaureate fellowship and graduate internship programs!

Welcome to our new Post-Baccalaureates for the 2024=2025 year!

Matt Kaeberlein, Ph.D., CEO of Optispan, Adjunct Professor of Oral Health Sciences at UW, and Co-Director of the Dog Aging Project presented  Longevity Science: From Molecules to Pets to Clinical Practice.

Latest LRI News:

T cells

Gamma Delta T Cells Show Promise Against Cellular Senescence

Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1]. How do we harness the immune system against senescence? Cellular

Lung fibroblasts

Using a Surface Biomarker to Target Senescent Cells

Scientists have identified a senescence-associated surface protein that can be targeted using antibodies [1]. This discovery might help distinguish between beneficial and harmful senescent cells and could speed up the development of senolytic therapies. This work was done by the Lifespan

Gene editing

Nuclear Expression of a Mitochondrial Gene in Mice

Scientists from the Longevity Research Institute (LRI), which was formed by the merger of SENS Research Foundation and Lifespan.io, have achieved expression of an essential mitochondrial gene in the nucleus and proper functioning of the protein. This could pave the

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