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Larisa Sheloukhova, Ph.D.

About Larisa Sheloukhova, Ph.D.

Larisa is a recent graduate from Okinawa Institute of Science and Technology located in one of the blue zones. She is a neurobiologist by training, a health and longevity advocate, and a person with a rare disease. She believes that by studying hereditary diseases it’s possible to understand aging better and vice versa. In addition to writing for LEAF, she continues doing research in glial biology and runs an evidence-based blog about her disease. Larisa enjoys pole fitness, belly dancing, and Okinawan pristine beaches.

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Abstract DNA
In a new study published in Nature Structural and Molecular Biology, researchers have demonstrated that by manipulating the DREAM protein complex, a major regulator of DNA damage response, it might be possible to alter the number of DNA mutations accumulated with age [1]. Mutations and DREAMs DNA mutations spontaneously occur in both germ-line (reproductive) cells...
Running seniors
In a new systemic review published in Autophagy Reports, researchers have demonstrated that exercise plays a role in regulating autophagy, depending on its type [1]. What is Autophagy?Autophagy, derived from ancient Greek, means "eating of self". Autophagy is the way cells break down misbehaving or nonfunctional organelles and proteins in the cell. This means that...
Fat mouse closeup
In a new study published in Endocrinology and Metabolism, researchers have shown that fat rather than sugar is the macronutrient that drives obesity and other detrimental metabolic changes if it constitutes a large proportion of dietary calories [1]. Obesity, diet, and the microbiome Obesity is associated with a dysregulation of several molecular pathways, which lead...
Mouse eating
In a new study published in Aging Cell, researchers have shown that two promising anti-aging agents, the antibiotic rapamycin and the anti-diabetic drug metformin, reverse aging in a population of intestinal stem cells [1]. The aging intestine Older people are more prone to gastrointestinal problems [2]. Moreover, aging is a major risk factor for various...
Exercise and supplements
In a new systematic review, researchers have shown that combining some dietary supplements and exercise might be beneficial for people over the age of 60 [1]. A double-edged sword Chronic low-level inflammation accompanies many hereditary and age-associated diseases. Inflammation also plays an important role in β€˜healthy’ aging, so it was recently acknowledged as another hallmark...
Food clock
In a paper published in Nature Aging, researchers have shown that caloric restriction modestly slows down the pace of aging in healthy young people as measured by one of the DNA methylation clocks [1]. CALERIE design A plethora of animal data has shown beneficial effects of caloric restriction for health and longevity. Human trials, albeit...