Tag: T Cells

Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy but also suggests that an immune system can be “overly youthful.” When generals become fighters CD4 T cells usually behave as “generals”, directing immune attacks...

Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Immune senescence drives inflammaging Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively...

Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping cells healthy Disabled MacroautophagyIn autophagy, damaged proteins and organelles are wrapped in a double-membraned autophagosome structure. These sacs then join with lysosomes, which act like...

Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1]. How do we harness the immune system against senescence? Cellular senescence, which occurs when cells subjected to stress stop dividing and start emitting pro-inflammatory signals,...

Researchers have found that removing senescent cells makes it easier for mice to fight initial infections but harder for them to develop immune memory. Senescence and immunity Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit...

In a paper published in Frontiers in Endocrinology, researchers have shown that transplanted young ovarian tissue improves the immune function of old recipient mice even if they are hormone-depleted [1]. Not just a reproductive matter Although women generally live longer than men, women spend almost half of their lives in poorer health due to reproductive...