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Tag: p16Ink4a

March 19, 2020
A study published in Aging shows that not only do different cell types express different levels of the senescence markers p16 and p21, these markers increase, and occasionally decrease, at different rates. Senescence and its markers Senescent cells are known to be harmful in excess, as they do not support their tissues and excrete the...
February 11, 2020
At the recent Longevity Therapeutics Conference in San Francisco, we had the chance to interview Lewis Gruber of SIWA Therapeutics and discuss his company's senotherapeutic approach to cancer and senescent cells. He was accompanied by his wife, Misty, who is the CFO of SIWA. Many of our readers are familiar with CAR-T immunotherapy, which has...
August 28, 2019
Researchers have launched a new database dedicated to mapping and understanding the complexity of cellular senescence in a bid to help us fully understand this age-related phenomenon.  Introducing the CellAge database The Human Ageing Genomic Resources (HAGR) is a series of databases and tools that have been developed to aid researchers on aging and help...
June 14, 2019
In a new study, researchers have found that the zinc-finger transcription factor Slug is responsible for repressing p16Ink4a, a compound that promotes senescence in human tissue. The researchers suggest that Slug is worth exploring as a treatment for sarcopenia [1]. Satellite cells Satellite cells are specialized stem cells that form new muscle cells when the...