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Tag: p16Ink4a

Smoking mouse
Researchers publishing in Aging Cell have described how treating the increased senescent cell burden that comes with cigarette smoke exposure can repair some of the damage. Senescent cells and COPD Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which...
Cascading Waterfall
In a study recently published in Biochemistry and Biophysics Reports, researchers have shown that growing natural killer (NK) cells and re-introducing them back into the human bloodstream reduces senescence markers in a wide variety of immune cells. Peripheral blood mononuclear cells This research focuses on peripheral blood mononuclear cells (PBMCs), a category that includes T...
Mice and food
New senolytics data was released from Dr. James L. Kirkland’s Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that Ξ±-Klotho protein decreases with age in mice and humans [2,3]. It has also been demonstrated that mice that lack Ξ±-Klotho have shorter lifespans, cognitive impairment, sarcopenia, vascular dysfunction, osteopenia, cardiac hypertrophy...
Diabetes Heart
The latest research published in Diabetes has implicated senescent cardiac stem cells as the link between diabetes and cardiovascular disease [1]. Why does diabetes increase the risk of cardiovascular disease? Type 2 diabetes mellitus is closely related to aging. Aging is a major risk factor for diabetes, and individuals with diabetes exhibit several characteristics of...
Death sentence
Researchers publishing in Science have found that the well-known biomarker p21 starts a fatal timer for mouse liver cells. Get better or die As the researchers demonstrate, the cyclin-dependent kinase inhibitor p21, which is encoded by the Cdkn1a gene, is associated with its own secretome: the p21-associated secretory phenotype (PASP). Similar but not identical to...
Ginseng
A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours after exercise. An experiment to link p16INK4a, aging, exercise, and Rg1 The cell cycle inhibitor p16INK4a, which is also a well-known biomarker of senescent cells,...