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Tag: p16Ink4a

Mice and food
New senolytics data was released from Dr. James L. Kirkland’s Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that α-Klotho protein decreases with age in mice and humans [2,3]. It has also been demonstrated that mice that lack α-Klotho have shorter lifespans, cognitive impairment, sarcopenia, vascular dysfunction, osteopenia, cardiac hypertrophy...
Diabetes Heart
The latest research published in Diabetes has implicated senescent cardiac stem cells as the link between diabetes and cardiovascular disease [1]. Why does diabetes increase the risk of cardiovascular disease? Type 2 diabetes mellitus is closely related to aging. Aging is a major risk factor for diabetes, and individuals with diabetes exhibit several characteristics of...
Death sentence
Researchers publishing in Science have found that the well-known biomarker p21 starts a fatal timer for mouse liver cells. Get better or die As the researchers demonstrate, the cyclin-dependent kinase inhibitor p21, which is encoded by the Cdkn1a gene, is associated with its own secretome: the p21-associated secretory phenotype (PASP). Similar but not identical to...
Ginseng
A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours after exercise. An experiment to link p16INK4a, aging, exercise, and Rg1 The cell cycle inhibitor p16INK4a, which is also a well-known biomarker of senescent cells,...
Bosu exercise
A new study published in Aging Cell shows that a 12-week program of structured exercise lowers the activity of the inflammatory SASP in people in their mid-60s. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
Two mice
A team of researchers led by Dr. Judith Campisi of the Buck Institute has discovered valuable information about how cells express the senescence marker p21 [1]. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead,...