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Tag: p16Ink4a

Ginseng
A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours after exercise. An experiment to link p16INK4a, aging, exercise, and Rg1 The cell cycle inhibitor p16INK4a, which is also a well-known biomarker of senescent cells,...
Bosu exercise
A new study published in Aging Cell shows that a 12-week program of structured exercise lowers the activity of the inflammatory SASP in people in their mid-60s. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
Two mice
A team of researchers led by Dr. Judith Campisi of the Buck Institute has discovered valuable information about how cells express the senescence marker p21 [1]. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead,...
Lung senescence tissue markers
A study published in Aging shows that not only do different cell types express different levels of the senescence markers p16 and p21, these markers increase, and occasionally decrease, at different rates. Senescence and its markers Senescent cells are known to be harmful in excess, as they do not support their tissues and excrete the...
Interview with Lewis Gruber
At the recent Longevity Therapeutics Conference in San Francisco, we had the chance to interview Lewis Gruber of SIWA Therapeutics and discuss his company's senotherapeutic approach to cancer and senescent cells. He was accompanied by his wife, Misty, who is the CFO of SIWA. Many of our readers are familiar with CAR-T immunotherapy, which has...
server room
Researchers have launched a new database dedicated to mapping and understanding the complexity of cellular senescence in a bid to help us fully understand this age-related phenomenon.  Introducing the CellAge database The Human Ageing Genomic Resources (HAGR) is a series of databases and tools that have been developed to aid researchers on aging and help...