May 21, 2025
In a recent study, researchers investigated how restricting dietary methionine and inhibiting the tyrosine degradation pathway affects healthspan in aged mice. While affecting tyrosine didn’t show any benefits, methionine restriction improved many, but not all, measures of healthspan, including frailty, pathological disease burden, and neuromuscular function [1]. Aging of metabolism Changes in metabolism accompany aging...
November 28, 2023
A new study reports a massive 33% increase in median lifespan in male genetically heterogeneous mice following prolonged isoleucine restriction [1]. Not all calories are created equal Caloric restriction is the most powerful life-extending intervention in rodents and primates [2], but the needed magnitude (about 30% fewer calories) is virtually impossible to maintain in humans...
