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Tag: Cognitive Decline

Mice playing
A study published in Nature Communications has shown that an environment rich in stimuli changes the epigenetics of the mouse hippocampus, making the brains of aged mice more like those of young mice [1]. What is an enriched environment? For mice, enriched environments (ENRs) are "large cages equipped with frequently rearranged toys, providing physical, cognitive,...
Rat in maze
Researchers from Hebei Medical University in China have found that testosterone supplementation ameliorates age-related brain dysfunction in male rats. A focus on mitochondria Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause increasing levels of...
Blood cells in an artery
A mouse study published in Aging Cell has outlined the similarities between artificially restricted cerebral blood flow and the reduced blood flow associated with aging. Aiming to understand vascular dementia Prior research has shown that reduced cerebral blood flow, known as hypoperfusion, results in vascular dementia and brain atrophy through multiple mechanisms, including neuroinflammation and...
Spermidine supplement may slow down aging.
Recently published research in Cell Reports provides a detailed account of dietary spermidine improving cognition and mitochondrial function in flies and mice, with some prospective human data to top it off. Spermidine and longevity Spermidine is known to decline with aging, and treatment with spermidine extends lifespan across various species. While it has a myriad...
Astrocyte
Scientists have successfully reprogrammed astrocytes (a type of brain cell) into healthy neurons in the brains of living mice. This technique could potentially be used for replenishing the neuronal population in people suffering from brain damage and age-related cognitive decline [1]. BrainThe brain is perhaps the most important organ in the body. While many organs...
Alzheimer's disease
Until now, it was unclear as to whether drugs that clear amyloid, which accumulate in the brain during aging and accompany diseases such as Alzheimer's, have any influence over cognitive decline. Previous studies have aimed to find this out, but results have been inconclusive due to study designs, hard-to-interpret data, and other issues that muddy...