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Tag: Autophagy

Clogged pipes
In a new study published in Oxidative Medicine and Cellular Longevity, the researchers have shown that klotho ameliorates vascular calcification via increased autophagy [1]. ‘Rusty’ arteries Vascular calcification, the deposition of minerals in the cardiovascular system, is a complex pathological process that accompanies aging. It is associated with an increased risk of stroke, coronary artery...
Fat rat
In a new study published in Scientific Reports, researchers have uncovered the molecular mechanism underlying the link between obesity and joint degeneration [1]. Obesity and osteoarthritis Obesity accelerates aging and is associated with several age-associated diseases, including osteoarthritis, an inflammatory condition that leads to joint degeneration. Obesity is often accompanied by low-grade chronic inflammation, which...
Smooth muscle
A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue [1]. Waiting until needed This paper begins with a discussion of quiescent muscle stem cells, which are held in reserve until injury causes them to form new somatic muscle cells,...
New Hallmarks
Publishing in Aging five months after their panel discussion in Copenhagen, many well-known researchers have explained their reasons for wishing to add new hallmarks of aging to the existing paradigm. A new addition to an old paradigm What is Aging? The Nine Reasons We AgeAging is a series of processes that include direct damage, accumulation...
Glutamine
A new study published in Frontiers of Pharmacology has shown that glutamine deprivation might speed up aging while glutamine supplementation reduces oxidative stress-induced senescence in mice [1]. Glutamine is an amino acid of paramount importance for many cellular functions. It is involved in the synthesis of various crucial molecules, such as the neurotransmitter glutamate and...
VitaDAO Korolchuk Lab
The laboratory of Viktor Korolchuk, Professor of Molecular Cell at Newcastle University, has received funding to research autophagy activators and ways in which they can help prevent age-related diseases. Visit the VitaDAO website to learn how you can get involved. Defective autophagy inhibits the function of cells, such as DNA repair and metabolic processes, and...

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