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Tag: Autophagy

Elderly eyes
In a new paper published in Aging, researchers have determined that directly improving autophagy through flubendazole (FLBZ) is potentially useful in treating dry age-related macular degeneration (AMD), a disease that causes vision loss. An accumulation of lipids Dry AMD shares a surprising commonality with atherosclerosis. As our macrophages attack the fatty (lipid) deposits in our...
Spermidine supplement may slow down aging.
Recently published research in Cell Reports provides a detailed account of dietary spermidine improving cognition and mitochondrial function in flies and mice, with some prospective human data to top it off. Spermidine and longevity Spermidine is known to decline with aging, and treatment with spermidine extends lifespan across various species. While it has a myriad...
Autophagy
Genes in the sirtuin family are conserved across a wide range of species and are involved in cellular metabolism, immune response, and aging. SIRT1 is known to decline during aging, but the mechanisms involved in this process were not known. Now, an international team has clarified how SIRT1 is regulated during cellular senescence [1]. Why...
Glia Alzheimer's
The macrophages resident in the brain and spinal cord appear to be a key element in the progression of Alzheimer's disease, according to the results of a new mouse study. Microglial mayhem As we age, our immune cells become increasingly dysfunctional; once-helpful cells can behave in harmful ways, promoting persistent inflammation, impairing tissue regeneration, and...
For the June edition of Journal Club, Dr. Oliver Medvedik and guests took a look at the recent human trial of urolithin A, a metabolite produced by microflora and an active ingredient in pomegranates that is linked to increased levels of mitophagy in aged animals. Urolithin A is a byproduct created when bacteria in the...
Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases. Samsara Therapeutics, Inc. ("Samsara,") a platform biotechnology startup engaged in the discovery and development of compounds that address the primary molecular causes of aging, announced today...