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Tag: Autophagy

VitaDAO Korolchuk Lab
The laboratory of Viktor Korolchuk, Professor of Molecular Cell at Newcastle University, has received funding to research autophagy activators and ways in which they can help prevent age-related diseases. Visit the VitaDAO website to learn how you can get involved. Defective autophagy inhibits the function of cells, such as DNA repair and metabolic processes, and...
Mouse test
In a new study published in Pharmacology Biochemistry and Behavior, researchers have shown that a combination of two compounds targeting different autophagy pathways is effective in fighting the pathological mechanism of Alzheimer's disease in a mouse model [1]. Cleaning up is a big deal The accumulation of "junk", such as misfolded proteins and damaged organelles,...
Lab mouse in hand
Researchers publishing in Aging have found that the anti-malarial drug chloroquine increases lifespan in male NRMI mice. The NRMI, like the Black 6, is a standard breed widely used in research, and these mice were not directly genetically modified. Substantial positive lifespan effects We have previously reported a study showing that choloroquine increases longevity in...
LSN CBD
On this episode of Lifespan News, Ryan O'Shea discusses how CBD promotes autophagy, our cells' ability to clear out damaged components. Script Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms. Two of the most well-known components of marijuana are tetrahydrocannabinol, or...
CBD oil
Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms. Two of the most well-known components of marijuana are tetrahydrocannabinol (THC) and cannabidiol (CBD). They have the same atomic composition, but differ in structure and in some of their qualities. THC is what...
Fruit flies
In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong treatment, including lifespan extension in flies [1]. Rapamycin is considered one of the most promising geroprotective drugs. It belongs to a handful of molecules that...