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Tag: Autophagy

Running seniors
In a new systemic review published in Autophagy Reports, researchers have demonstrated that exercise plays a role in regulating autophagy, depending on its type [1]. Manipulating autophagy  Disabled autophagy was recently acknowledged as a hallmark of aging. Indeed, boosting the ability of cells to get rid of unnecessary and damaged organelles and molecules is considered...
Ultrasound Machine
In a preprint paper, the researchers have shown that low-frequency ultrasound treatment decreases senescence and improves the physical performance of aged mice [1]. Mechanical approach Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...
Updates
The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks of cancer [1,2]. These papers were authored by the same team that published the original 2013 Hallmarks of Aging paper [3]. The Hallmarks of AgingThere...
Publishing in Free Radical Biology and Medicine, a team of Chinese researchers has investigated the potential role of autophagy in fighting oxidative stress and potentially staving off age-related macular degeneration (AMD). AMD, oxidative stress, and autophagy AMD comes in two major forms. In the nonexudative (dry) form, material builds up behind the retina, while in...
Clogged pipes
In a new study published in Oxidative Medicine and Cellular Longevity, the researchers have shown that klotho ameliorates vascular calcification via increased autophagy [1]. ‘Rusty’ arteries Vascular calcification, the deposition of minerals in the cardiovascular system, is a complex pathological process that accompanies aging. It is associated with an increased risk of stroke, coronary artery...
Fat rat
In a new study published in Scientific Reports, researchers have uncovered the molecular mechanism underlying the link between obesity and joint degeneration [1]. Obesity and osteoarthritis Obesity accelerates aging and is associated with several age-associated diseases, including osteoarthritis, an inflammatory condition that leads to joint degeneration. Obesity is often accompanied by low-grade chronic inflammation, which...