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Tag: Autophagy

August 30, 2019
The macrophages resident in the brain and spinal cord appear to be a key element in the progression of Alzheimer's disease, according to the results of a new mouse study. Microglial mayhem As we age, our immune cells become increasingly dysfunctional; once-helpful cells can behave in harmful ways, promoting persistent inflammation, impairing tissue regeneration, and...
June 23, 2019
For the June edition of Journal Club, Dr. Oliver Medvedik and guests took a look at the recent human trial of urolithin A, a metabolite produced by microflora and an active ingredient in pomegranates that is linked to increased levels of mitophagy in aged animals. Urolithin A is a byproduct created when bacteria in the...
March 06, 2019
Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases. Samsara Therapeutics, Inc. ("Samsara,") a platform biotechnology startup engaged in the discovery and development of compounds that address the primary molecular causes of aging, announced today...
February 28, 2019
In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known example of how cells purge their waste, and another is the ubiquitin-proteasome system (UPS). Researchers are working on ways to boost the activity of the...
December 17, 2018
Researchers have discovered a link between the cellular recycling system known as autophagy and the behavior of microglial immune cells during aging. We have discussed the polarization of macrophages in a number of previous articles, and it has become quite a hot topic among researchers in the last few years. Microglia are tissue-resident macrophages in...
November 28, 2018
Today, we want to discuss this review published in the journal Science, as it provides a whistle-stop tour of caloric restriction, intermittent fasting, and time-restricted feeding. There is a considerable amount of data supporting the effects of caloric restriction and similar dietary approaches on both health and lifespan in multiple species. In general, the more...