ร—

Lifespan News – Tearing Cells

Senescent cells leave pieces of themselves glued to other cells.

Share







LSN Cells RippingLSN Cells Ripping

On this episode of Lifespan News, Emmett Short focuses on a recently published paper in which senescent cells tear off portions of their membranes, leaving them attached to other cells.

To do this, we need your support. Your charitable contribution tranforms into rejuvenation research, news, shows, and more. Will you help?

Script

Senescent cells and dad jokes are both hallmarks of aging. Theyโ€™re outdated, irritating and both make you die a little inside. But new research has given scientists fresh insight that could help us fight back against these destructive relics. Well, senescent cells. Yeah, thereโ€™s been very little progress on dad jokes.

Welcome to lifespan news. I’m Emmett Short. Today we’re talking about new Research into senescent cells that found they can adhere to neighboring cells, eventually ripping apart and leaving fragments of themselves inside their victims. Reminds me of an ex-girlfriend. Anyway, learning how they work could help us figure out the relationship between senescent cells and cancer.

Cellular senescence is central to aging. Thatโ€™s actually the sentence I use to do a mic check. “Cellular Senescence is centralโ€ฆ weโ€™re good? Ok.”

These are like old cells hanging out at the party that keep saying inflammatory things and they just won’t leave. Thereโ€™s a lot more to it than that. For a great breakdown of these Zombie Cells, definitely check out this video from Lifespan.ioโ€™s Life Noggin channel created with the support of the SENS Research Foundation.

So, in this new preprint study, scientists marked 1 out of every 1000 cells with a fluorescent protein.ย  In group one, the fluorescent cells were senescent. In the second group, it was the opposite. In the third group, all cells were senescent, and, finally, the control group contained only healthy cells.

What they found was pretty amazing. After a few days, tiny fluorescent dots started to appear. The cells were already tiny but these new dots were even tinier, and they turned out to be cellular fragments attached to the membranes of other cells. Time-lapses showed how the cells moved around and bumped into each other. Contacts between non-senescent cells were brief and ended without damaging either cell but, if at least one of the cells was senescent, they sometimes bonded together. Then as the cells eventually moved apart, the senescent cell was torn, leaving a part of itself attached to the other cell as you can see in this actual video taken with a microscope.

The fragments began appearing just 3 days after the induction of senescence, and by day 4, there were an average of 10-12 fragments per senescent cell. Itโ€™s like they sweat super glue and keep bumping into things. Itโ€™s not ideal. Making things worse the fragments exhibited โ€œspinning, projecting and retracting arms, or crawling-like behaviorโ€. Yikes! Itโ€™s like walking dead inside your body.

The researchers also wanted to see what effects the fragments have on the cells. Adding these fragments to liver cancer cells increased their growth rate. In 3D culture, cancer cells with the fragments became more active, invading the gel and forming branches. Which is super scary but at least we understand it better now which gets us one step closer to figuring out how to control it.

Now, I know I framed senescent cells in a pretty bad light here, but this is not the whole story. You may be thinking senescent cells bad. Maybe you want to cancel senescent cells from your bodies. But, Just like most things in life it’s a little more nuanced than that. There have been other studies that have demonstrated some benefits of senescence. So even down to the cellular level there’s good and evil in all of us and we’re going to need more information before we know how we should respond and when we get that information we’re not going to keep it to ourselves. Weโ€™ll make a video right away. So subscribe and click the bell so you donโ€™t miss out. Iโ€™m Emmett Short, and weโ€™ll see you next time on Lifespan News!

ADVERTISEMENT

A link to a supplement website called NOVOS.

We would like to ask you a small favor. We are a non-profit foundation, and unlike some other organizations, we have no shareholders and no products to sell you. We are committed to responsible journalism, free from commercial or political influence, that allows you to make informed decisions about your future health.

All our news and educational content is free for everyone to read, but it does mean that we rely on the help of people like you. Every contribution, no matter if itโ€™s big or small, supports independent journalism and sustains our future. You can support us by making a donation or in other ways at no cost to you.

Lifespan News – Elon Musk and the Living Forever Curse

On this episode of Lifespan News, Ryan O'Shea ruminates on Elon Musk's statement on living forever being a curse rather...

Lifespan News – Age Reversal Pill

For this episode of Lifespan News, Emmett Short talks about David Sinclair's serious effort to epigenetically rejuvenate cells by using...

Lifespan News – When Should You Die?

On this episode of Lifespan News, Ryan O'Shea talks about a real-world doctor whose euthanasia-related statements parallel those found in...

Lifespan News โ€“ Preventing Disease with AI

On this episode of Lifespan News, Emmett Short talks about what can be done to modify the healthcare system in...

CategoryLifespan News, News
  1. James Flint
    January 31, 2023

    Senescent – How about a serious commentator on serious subjects? Cute and clever have their places but not on this site.

    They are:pronounced: https://www.merriam-webster.com/dictionary/senescent senescent
    si-หˆne-sแตŠnt
    adjective

Write a comment:

*

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.