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Reason .

Reason .

About Reason .

Long-time advocate for rejuvenation biotechnology and director of the aging research website Fight Aging. Reason is also the founder of Repair Biotechnologies,  a new venture that will focus on the development of gene therapies relevant to human rejuvenation. Their initial focus is on the development of gene therapies to regenerate the thymus, which has the potential to restore production of T cells in older individuals, or may help patients suffering from immunodeficiency.

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Articles from this author

Fight Aging!
September 27, 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services...
Amyloid Precursor Protein Glycosylation is Different in the Alzheimer’s Brain
September 25, 2020
The puzzle of Alzheimer's disease is why it only occurs in some people. Unlike other common age-related diseases, such as atherosclerosis, it isn't universal, even in groups exhibiting all of the lifestyle risk factors. Thus a strong theme in the Alzheimer's research community is the search for clear and robust differences in cellular biochemistry between...
Naringenin is a Senotherapeutic that Enhances Neurogenesis in Mice
September 25, 2020
Researchers here evaluate the flavonoid naringenin for its ability to dampen the inflammatory signaling of senescent neural cells, particularly levels of TNF-α, and increase neurogenesis in mice. This increased neurogenesis is likely a result of reduced inflammation in brain tissue, but possibly due to other, distinct mechanisms. Neurogenesis is the name given to the generation...
A Discussion of Targeting the Mechanisms of Cardiovascular Aging
September 25, 2020
This very readable open access paper discusses some of the mechanisms involved in cardiovascular aging. As for many such publications, and to my eyes at least, it leans too much towards the details of the aged metabolism rather than towards the underlying causes that make the cells of an aged cardiovascular system behave differently. Near...
Rescuing Senescent Cells by Delivering New Mitochondria Sounds Like a Risky Proposition
September 24, 2020
Mitochondria are effectively power plants, hundreds of these organelles per cell working to create the chemical energy store molecule adenosine triphosphate. Mitochondria are the descendants of ancient symbiotic bacteria, and retain many bacterial characteristics, including a small genome, the mitochondrial DNA, and the ability to replicate. Mitochondrial dysfunction is one of the paths by which...
Theorizing on Cosmic Radiation as an Accelerator of Aging via Cellular Senescence
September 24, 2020
Researchers here suggest that some of the detrimental effects of prolonged space missions are mediated by an increased burden of senescent cells resulting from cosmic radiation exposure. Senescent cell accumulation is a feature of aging and cancer treatments such as chemotherapy, and contributes to the progression of age-related dysfunction and disease. Senescent cells secrete an...