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Reason .

Reason .

About Reason .

Long-time advocate for rejuvenation biotechnology and director of the aging research website Fight Aging. Reason is also the founder of Repair Biotechnologies,  a new venture that will focus on the development of gene therapies relevant to human rejuvenation. Their initial focus is on the development of gene therapies to regenerate the thymus, which has the potential to restore production of T cells in older individuals, or may help patients suffering from immunodeficiency.

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Articles from this author

Molecules Leaking from Damaged Muscle Fibers can Activate Muscle Stem Cells
October 19, 2020
Declining muscle stem cell function appears likely to be the most important contributing cause of sarcopenia, the characteristic loss of muscle mass and strength with age. Studies of the stem populations that support muscle tissue have suggested that the cells are largely intact and capable, but quiescent. This may be a reaction to changes in...
Targeting NAD+ Metabolism for the Treatment of Cardiovascular Disease
October 19, 2020
Nicotinamide adenine dinucleotide (NAD+) is important to mitochondrial function, the supply of chemical energy store molecules to power cellular processes, and thus to cell and tissue function. Levels of NAD+ decline with age, a part of the deterioration of mitochondrial function throughout the body:. Too little NAD+ is created, too little NAD+ is recycled after...
Fight Aging!
October 18, 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services...
Using CRISPR to Remove Mutated Sequences of Nuclear DNA Required by Cancerous Cells
October 16, 2020
Fusion genes feature in many cancers, a form of mutation in which two genes are joined together, such as through deletion of the DNA sequences that normally separate the two genes. The resulting mutant fusion gene sequence encodes a fusion protein that can have novel effects, or in which both portions remain functional, but are...
Investigating Zebrafish Biochemistry in Search of Mechanisms of Neural Regeneration
October 16, 2020
Zebrafish are highly regenerative, capable of regrowing organs, and even nervous system tissue such as the retina. Research groups investigate these species in search of specific mechanisms of proficient regeneration, with the hope that they can be ported over to human biochemistry. In the best case scenario, mechanisms of this nature could still exist in...
More Work on Proteomic Clocks to Measure Biological Age
October 16, 2020
Researchers are these days producing a fair number of novel metrics capable of measuring age and mortality. Machine learning or similar approaches are used to mine epigenetic, proteomic, and transcriptomic data sets, in order to establish algorithmic combinations of epigenetic marks or expression of specific genes that change in characteristic ways with age. The work...