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Reason .

Reason .

About Reason .

Long-time advocate for rejuvenation biotechnology and director of the aging research website Fight Aging. Reason is also the founder of Repair Biotechnologies,  a new venture that will focus on the development of gene therapies relevant to human rejuvenation. Their initial focus is on the development of gene therapies to regenerate the thymus, which has the potential to restore production of T cells in older individuals, or may help patients suffering from immunodeficiency.

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Articles from this author

Fight Aging!
Frailty is a condition with a strong inflammatory component. It isn't just physical weakness, but also the vulnerability of an incapable and constantly overactive immune system, generating inflammatory signaling that disrupts tissue and organ function throughout the body. In recent years, there has been a considerable growth of interest in the gut microbiome and its...
Fight Aging!
An interesting body of scientific work exists to investigate the question of whether or not various forms of electromagnetic stimulation can improve tissue function, particularly in older people. To improve neurogenesis in an aging brain, or enhance nerve regrowth following injury, for example. Taken broadly, the manipulation of cells to specific ends via electromagnetism is...
Proposing Intermittent Fasting as an Approach to Slow Parkinson's Disease Progression
Intermittent fasting strategies, such as alternate day fasting, are known to slow aging in a variety of species. The mechanisms are likely similar to those involved in the calorie restriction response, meaning upregulation of stress responses and cellular maintenance, though intermittent fasting is capable of producing some degree of benefits even when overall calorie intake...
BAFT Upregulation Makes T Cells Resistant to Exhaustion
When faced with long-lasting challenges, such as cancer or persistent infections that the immune system struggles to clear, T cells of the adaptive immune system can become exhausted. The exhausted cells lose function, diminishing both the immediate immune response and the ability to form immune memory that will enable a robust future response to the...
Applying Senolytics to Improve Mesenchymal Stem Cells Before Transplantation
Cellular senescence occurs in response to stress, damage, and cells hitting the Hayflick limit on replication. Senescent cells cease replication, and begin to secrete a pro-inflammatory, pro-growth mix of signals. In cell cultures, senescence is a common phenomenon. Researchers are beginning to realize that the presence versus absence of senescent cells in culture may explain...
Peptide Coated Nanoparticles as a Basis for a Non-Invasive Test for Cancer
A reliable, low-cost means of early detection of cancer would be of great benefit. Approaches to the treatment are advancing to the point at which very early stage cancer has a high rate of survival, and the side-effects of treatments for early stage cancer are becoming less onerous. In the ideal world, a yearly physical...