Matthew O'Connor

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No getting fat
A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1]. Longevity hidden in the genome For decades, aging researchers have hoped that human genetics might reveal genuine “longevity genes” whose altered...
Three Against Cancer
In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
Forever Healthy Foundation
Staying informed about health and longevity interventions can be tedious and time-consuming. Often it involves manually decoding a supplement label with numerous compounds, reading a blog post about some therapy, or an X-post that name-drops a peptide — and having to look up every item manually. The Evipedia browser extension takes this challenge head-on. It...
Thymus in body
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made other cancer treatments more effective [1]. The aging immune system Aging has a profound impact on the immune system. It leads to a progressive decline in immune...
A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging [1]. A problem of great complexity A familiar puzzle in geroscience is that while many of the same longevity-related pathways are highly evolutionarily conserved, manipulating them...
Crowded blood cells
Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own The authors begin their paper by discussing high blood pressure (hypertension), one of the most commonly known medical issues and a significant contributor to both disability and...