Lifespan Research Institute

Matthew O'Connor

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Robot diagnostics
A new system, which consists of a large LLM and a network of agentic tools, outperformed several other models and human physicians [1]. Too rare to easily diagnose Rare diseases can be notoriously hard to diagnose. Patients average over 5 years to receive a correct diagnosis, enduring repeated referrals, misdiagnoses, and unnecessary interventions in what...
Doctor holding heart model
Researchers publishing in Aging have used Mendelian randomization to conclude that the inflammatory factor IL6 causes increased mortality and that its circulating receptor, IL6R, decreases it. Looking for a proof of danger Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection...
Older man thinking
A recent study suggests that cognitive enrichment throughout life is associated with reduced dementia risk, and it has the potential to delay the onset of dementia and mild cognitive impairment by five to seven years [1]. Cognitive stimulation Engagement in cognitively stimulating activities has been linked to lower dementia incidence, better cognitive function, and a...
NUS Healthy Longevity Conference
The NUS Academy for Healthy Longevity invites you to the Geromedicine Conference, set to take place from February 26-27, 2026, at the National University of Singapore. This premier event will gather global experts in geroscience, researchers, clinicians and industry leaders to explore the translation of geroscience into real-world interventions aimed at optimizing health and extending...
Healthy foods
Scientists have pitted five diets against each other to see which one is associated with more years of life gained [1]. The clash of the diets Unhealthy eating is recognized as a globally leading cause of death [2]. Surprisingly, few studies have actually evaluated the gains in life expectancy associated with adherence to a healthy...
Mouse in maze
Researchers have found that altering a growth hormone receptor in the brain adipose tissue of aged male mice slows their mental aging and allows them to perform far better on cognitive tests. Growth signaling is not necessarily good The axis of growth hormone and insulin-like growth factor 1 (IGF-1) is well-known in aging, and the...