Matthew O'Connor

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Clock and heart
A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying together two well-known aspects of aging Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection or obvious...
B cell releasing antibodies
Researchers have genetically engineered blood stem cells to produce B cells that can churn out rare broad-action antibodies to fight HIV, malaria, and flu. This platform can also be used to produce other essential proteins [1]. The rare gems Vaccination works because a small number of B cells, which recognize the vaccine antigen upon encountering...
Climbing mouse
In Aging Cell, researchers have described how suppressing the ghrelin receptor improves muscle function and fights sarcopenia in older mice. An appetite hormone with negative effects Ghrelin has been well-documented as stimulating both appetite and growth [1]. However, this hormone, which increases with aging [2], has negative effects in older organisms; deleting ghrelin has been...
Cynomolgus monkey
A recent study described a process called ferro-aging, in which iron accumulation leads to oxidative damage and cellular senescence. This process can be delayed by Vitamin C [1]. A two-faced atom Iron, like many components of biological systems, has two faces. On the one hand, it’s essential for developmental and metabolic processes [2, 3]. On...
Sauna
A new study shows that hitting a sauna for 30 minutes causes a transient spike in the number of circulating white blood cells. The researchers suggest that this exercise-like effect might provide health benefits by improving immune surveillance [1]. How does a sauna do its trick? Robust epidemiological data has associated sauna use with health...
Wrinkled skin
In Aging Cell, researchers have described how one dermal protein is related to maintaining the populations of fast-cycling skin cells and preserving skin integrity. Not all skin cells are the same The outer layer of the skin (the epidermis) is naturally regenerated by two distinct populations of stem cells: slow-cycling and fast-cycling [1]. The former...