Matthew O'Connor

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DNA clock
In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Waiting too long Testing lifespan-extending interventions in humans has a major problem: it can take many years, or even decades, to see results. Nobody wants to wait that long. Therefore, it is essential...
Food-Ignoring Mouse
In a new study, semaglutide given late in life increased median lifespan in female mice by more than 12% and improved various health markers. Semaglutide’s effect possibly went beyond caloric restriction [1]. Old mice, new drugs GLP-1 receptor agonists, which act on a hormone that regulates insulin secretion and appetite, have revolutionized obesity treatment, showing...
Running mouse
Researchers publishing in Aging Cell have described how stopping growth hormone receptor production in midlife significantly lengthens the lives of mice. Growth but diabetes Growth hormone affects the metabolism of fats (lipids), increasing the levels of circulating fatty acids while increasing insulin-like growth factor 1 (IGF-1) and impairing the function of insulin itself [1]. Growth...
Last Generation to Die
Filmmaker Tim Maupin has spent a number of years developing The Last Generation to Die, a near-future film about what happens when the first true rejuvenation technologies arrive and who gets left behind. The project has now reached the top 65 of the Future Vision XPrize, a global contest seeking optimistic visions of humanity’s future....
Longevity Science Foundation
Driven by ongoing support from their community, The Longevity Science Foundation is extending the deadline for the Invested in Her campaign to October 1, 2026, as they work toward a $250,000 fundraising target to support early-stage research into ovarian aging and menopause. Hundreds of millions of women live longer than men yet spend more years...
Rejuvenation Roundup August 2026
Properly untangling aging means untangling its various counterbalances, sometimes on the individual level. Here's what's been investigated this month. Interviews Wei-Wu He: People Should Become the CEOs of Their Own Health: Wei-Wu He is an unusual combination of scientist and businessman, and his current company focuses on using precision medicine to lengthen people's lives. Michael...