Matthew O'Connor

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Insilico Medicine
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software Earlier this week, the AI-driven drug discovery company Insilico Medicine announced a large-scale collaboration with the pharmaceutical giant Eli Lilly. The deal is worth up to...
Loose fat cells
In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat. This fat, itself, also ages; this paper describes it...
King penguins
A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated aging and changes in metabolic pathways [1]. A unique model system A sedentary lifestyle and obesity are linked to accelerated aging in humans and, at the molecular level,...
Rejuvenation Roundup March 2026
For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let's see what's been done last month to rejuvenate animals and people. Team and Activities Support the Human Ageing Genomic Resources: João Pedro de Magalhães has launched a fundraiser to help maintain this database, which has supported thousands of scientists worldwide in...
Immune cells
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune cells into the tumor? One of the central challenges in cancer immunotherapy is getting the right immune cells to the right place. Natural killer (NK) cells...
Lower back pain
Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of lower back problems Intervertebral disc degeneration (IDD) is one of the core reasons for lower back pain in older people. This nearly ubiquitous problem is a frequent target...