Matthew O'Connor

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Mitochondrial membrane
Scientists have found that the levels of phosphatidylcholine, the most abundant lipid in mitochondrial membranes, decline with age, driving mitochondrial aging in worms and possibly humans. Supplementing the lipid helped in an in vitro experiment [1]. What drives mitochondrial aging? Mitochondria are the cell's energy-generating organelles, and their decline is a hallmark of aging [2]....
Cataracts
Researchers have outlined a key receptor and protein involved in the formation of cataracts, paving the way for potential treatments targeting them. Oxidative stress and cataracts are closely related Cataracts, which cloud the lenses of the eye, are one of the most common sources of age-related vision loss [1]. While they are treatable through surgery...
Identifying DNA
In Aging Cell, researchers have described the differences between primary and secondary senescent cells, comparing radiation-induced senescence to senescence induced by the senescence-associated secretory phenotype (SASP). Heterogeneity on top of heterogeneity Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...
Beijing, China — In response to the growing healthcare demands of a rapidly ageing population, China has launched its first national competency-based education programme in longevity medicine, marking a significant step toward integrating healthy longevity and preventive care into mainstream clinical practice. The initiative was jointly developed by the China Non-public Medical Institutions Association and...
Targeting cancer
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assassination of cells CRISPR-based systems work by cutting or changing DNA at a particular spot, an ability that can be used to fix dangerous mutations, such as in the...
Reason Interview
We have spoken with Reason from Repair Biotechnologies about his company's lead candidate, REP-0004, a drug targeting the liver to reduce excess intracellular free cholesterol. The FDA has granted Repair Bio an orphan drug indication, and the company is aiming for clinical trials by mid-2027. Our conversation also touches on the regulatory challenges and the...