Matthew O'Connor

Related Organizations

Campaign List

Articles from this author

Immune cells
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune cells into the tumor? One of the central challenges in cancer immunotherapy is getting the right immune cells to the right place. Natural killer (NK) cells...
Lower back pain
Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of lower back problems Intervertebral disc degeneration (IDD) is one of the core reasons for lower back pain in older people. This nearly ubiquitous problem is a frequent target...
Rubedo
Rubedo Life Sciences, Inc. (Rubedo), an AI-driven, clinical-stage biotech focused on discovering and rapidly developing selective cellular rejuvenation medicines targeting aging cells, today announced preliminary results from a single-center, ascending-dose, randomized, double-blind, vehicle-controlled trial in patients with plaque psoriasis, atopic dermatitis, and skin aging (photo-aged skin). The recently completed Phase 1 clinical trial, conducted in the...
Mitochondria
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. The delivery problem Mitochondrial diseases are a diverse group of disorders that arise when mitochondria malfunction. They are often caused by mutations in mitochondrial DNA (mtDNA) itself or in...
Drug Development
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in longevity medicine. Senescent cells actually serve important roles in development, wound healing, and cancer prevention, but as they accumulate with age or pathology, they become harmful: they secrete...
A new study identified two polyunsaturated fatty acids, α-eleostearic acid (α-ESA) and α-ESA methyl ester (α-ESA-me), that showed senolytic activity in cell cultures and a mouse model [1]. An anti-aging strategy Cellular senescence is one of the most critical aging-related processes. Senescent cells, which accumulate with age, are arrested in the cell cycle and are resistant...