Lifespan Research Institute

Matthew O'Connor

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Fatty acid chains
Scientists have found that the ratio between poly- and monounsaturated fatty acids affects the viability of T cells as well as both humoral and anti-tumor immunity [1]. The iron death Some fats are broadly recognized as healthy while others are considered unhealthy, but the reality might be more complicated than that. Poly- and monounsaturated fats...
Inflamed Lungs
Researchers publishing in Aging Cell have discovered how older organisms' susceptibility to pneumonia is related to inflammatory factors. Short-lived infection fighters Polymorphonuclear leukocytes, more commonly known as neutrophils, are part of the first line of defense against lung infections. Illnesses cause these immune cells to be recruited from the bone marrow in a process called...
Woman lifting weight
Using brain clock models that analyzed MRI images of the brains of elderly people who underwent one year of resistance training, researchers concluded that both heavy and moderate resistance training slow brain aging [1]. The broad benefits Exercise has been linked to many benefits, such as lowering blood pressure, slowing down cancer progression, preventing fitness...
Synapses
Scientists have discovered that ATP deficiency disrupts dopamine processing in synapses, leading to the accumulation of the harmful protein species that characterize Parkinson’s disease. ATP supplementation helps, but the road to the clinic might be long [1]. Parkinson’s and dopamine Parkinson's disease is defined by two hallmarks: the death of dopamine-producing neurons in a midbrain...
Rejuvenation Roundup February 2026
Plenty of crucial work has been done in the rejuvenation world over the past four weeks, and last month, we've spoken to several researchers about the progress being made. Interviews João Pedro de Magalhães on the Ethics of Longevity: João Pedro de Magalhães, professor at the University of Birmingham, is a skilled longevity advocate who...
Cells
Cellular reprogramming is one of the technologies most associated with longevity. The field was created in 2006, when Shinya Yamanaka showed that a cocktail of four transcription factors, commonly known as OSKM, can cause de-differentiation and massive rejuvenation of a cell, creating an iPSC (induced pluripotent stem cell). About a decade later, partial reprogramming was...