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Introducing the Public Longevity Group: Building the Future of Public Trust
Building the first public sentiment analysis engine to unlock public trust in longevity.
- 104% Funded
- $104,395 Funded
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Pearl: Participatory Evaluation of Aging with Rapamycin for Longevity
The first large-scale placebo-controlled clinical trial to determine the effects of Rapamycin on human longevity.
- 243% Funded
- $182,838 Funded
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MitoMouse: SENS Transgenic Mouse Project
Creating a transgenic mouse demonstrating the rescue of Mitochondrial DNA mutations in mammals. We will express the mitochondrial ATP8 gene from the nucleus as...
- 155% Funded
- $77,625 Funded
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Can NMN Increase Longevity?
The first long-term lifespan study in mice involving supplementation with NMN, a precursor of NAD+ metabolism, which has been shown to reduce aging markers and...
- 250% Funded
- $75,285 Funded
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MouseAge: Visual Biomarker for Mouse Aging
Using AI and Computer Vision Techniques to Determine Age and Assess the Effect of Therapies Against Aging in Mice, Increasing the Pace of Research.
- 130% Funded
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AgeMeter: Functional Age Biomarkers
Developing a diagnostic system to measure human functional age in comparison to chronological age, and assist in the assessment of anti-aging therapeutics.
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CellAge: Targeting Senescent Cells With Synthetic Biology
Designing better systems for detection and safe removal of dysfunctional “senescent” cells to improve health and treat age-related diseases.
- 171% Funded
- $34,215 Funded
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OncoSENS Control ALT Delete Cancer
High-throughput screening of a library of diverse drugs to find treatments for ‘ALT’ cancers, those which rely on Alternative Lengthening of Telomeres.
- 120% Funded
- $72,002 Funded
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The Major Mouse Testing Program
Testing a new class of compounds, Senolytics, on their ability to extend healthy lifespan by clearing out dysfunctional cells in the body.
- 115% Funded
- $52,075 Funded
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Articles from this author
June 22, 2026
Researchers have found that bound pieces of RNA and DNA in the cytoplasm of senescent cells encourage these cells to secrete inflammatory factors. When transcription gets sticky As part of the transcription process that produces necessary proteins, RNA must chemically interact with DNA. When it binds to DNA and integrates itself into the genome, it...
June 19, 2026
Scientists have targeted the thin fat layer around blood vessels with a transcription inhibitor, reducing symptoms of cardiometabolic disease [1]. When vessels can’t “just relax” Cardiometabolic disease (CMD) – characterized, among other things, by obesity combined with high blood pressure – is one of the largest drivers of cardiovascular death [2]. It does its damage...
June 18, 2026
In Aging Cell, researchers have described the way that antioxidants work against senescence in muscle cells by altering mTOR signaling. Senescent cells don't sense nutrients properly Deregulated Nutrient SensingThe four pathways of nutrient-sensing regulate metabolism and influence aging. The four associated key protein groups are IGF-1, mTOR, sirtuins, and AMPK. We call these proteins “nutrient-sensing”...
June 16, 2026
In a new study, muscle-targeted viral-vector-based delivery of the protein FGF21 significantly increased median lifespan in male mice and improved many healthspan markers [1]. Control your energy Metabolic dysregulation is a core cause of aging [2]. As animals (and people) age, they tend to gain fat, develop insulin resistance, and run their cellular energy systems...
June 15, 2026
A team of reviewers has taken a look at the relationship between cancer, cellular senescence, and vascular overgrowth and published this information in Aging Cell. Different gut cancers form through different pathways The authors begin their paper by discussing two cancers that are downstream of inflammatory bowel disease (IBD): colorectal cancer (CRC) [1] and colitis-associated...
June 11, 2026
Scientists have “faked” sleep in mice by artificially creating the on/off neuronal firing pattern similar to that seen in non-REM sleep. This produced sleep-like effects, including improved learning memory [1]. Can sleep be emulated? Getting proper amounts and quality of sleep is one of the best things for health and longevity [2], but in modern...