Matthew O'Connor

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Jose Pedro Castro Interview
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in Health at the University of Porto, has been studying inflammation and its crucial role in aging and disease. Earlier this month, he received the Rising...
A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to...
Montana State Legislature
Montana’s first experimental treatment review board has brought three longevity heavyweights into the state’s effort to expand access to experimental therapies. How much regulation is too much? Many people in the longevity field will tell you that regulation is holding it back. Sensible oversight of novel therapies is essential, but an overly cautious interpretation of...
In Aging Cell, researchers have published an explanation of how neutrophil extracellular traps (NETs) worsen UVB damage and how inhibiting them alleviated this damage in a mouse model. When defenders just make things worse Immune activation is a common response to damage, as the immune system often perceives such damage as a pathogenic attack. Activation...
Snake oil
According to the experts that we spoke to, the death, which followed an intravenous NAD⁺ infusion that went catastrophically wrong, underscores the risks of unproven treatments and the need for rigorous longevity medicine. Earlier this week, Elizabeth Baron, a 27-year-old woman from New York City, died after receiving an intravenous infusion at a local “wellness...
The kidney
Autophagy, which increases in younger mice under toxic stress, does not increase in older mice and leaves them susceptible to acute kidney injury (AKI). Increasing autophagic flux by targeting a key molecule, transcription factor EB (TFEB), alleviates some of this damage. An acute disease with lasting effects AKI is a rapidly developing condition that causes...