Matthew O'Connor

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Hiking on Easter Island
According to a new study, rapamycin probably interferes with exercise, blunting its effects in older human subjects. This result, however, might be specific to the particular protocol. Can they work together? Physical activity is one of the most potent pro-longevity interventions currently available [2]. Rapamycin is the undisputed champion of small molecules for extending lifespan...
BioAge Labs
BioAge Labs, Inc. (Nasdaq: BIOA) ("BioAge" or the "Company"), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging, today reported results from the Phase 1 clinical trial of BGE-102, a potent, structurally novel, orally available, brain-penetrant small molecule NLRP3 inhibitor. The full dataset, which includes a...
Clock and heart
A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying together two well-known aspects of aging Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection or obvious...
B cell releasing antibodies
Researchers have genetically engineered blood stem cells to produce B cells that can churn out rare broad-action antibodies to fight HIV, malaria, and flu. This platform can also be used to produce other essential proteins [1]. The rare gems Vaccination works because a small number of B cells, which recognize the vaccine antigen upon encountering...
Climbing mouse
In Aging Cell, researchers have described how suppressing the ghrelin receptor improves muscle function and fights sarcopenia in older mice. An appetite hormone with negative effects Ghrelin has been well-documented as stimulating both appetite and growth [1]. However, this hormone, which increases with aging [2], has negative effects in older organisms; deleting ghrelin has been...
Cynomolgus monkey
A recent study described a process called ferro-aging, in which iron accumulation leads to oxidative damage and cellular senescence. This process can be delayed by Vitamin C [1]. A two-faced atom Iron, like many components of biological systems, has two faces. On the one hand, it’s essential for developmental and metabolic processes [2, 3]. On...