Lifespan Research Institute

Matthew O'Connor

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Gut-brain axis
A new study suggests that microbiome remodeling is a mechanism behind age-related cognitive decline, with one particular bacterial species identified as the likely culprit. In mice, antibiotics seem to reverse this effect [1]. The gut-brain axis and the microbiome Memory decline is a common and debilitating feature of aging, but its mechanisms remain poorly understood....
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For the third summer in a row, Longevity Xplorer (LongX) is opening applications for the Xplore Program, a fully remote summer fellowship designed to help students and early-career professionals translate interest in longevity into practical experience. The program is structured to do two things well: (1) build a shared foundation in aging biology and the...
Vitalist Bay
BERKELEY, CA — The Vitalism Foundation announces Vitalist Bay 2026, the world’s largest longevity festival, returning to the Lighthaven Campus in Berkeley, California from May 14–17, 2026. Now in its second year, Vitalist Bay condenses the scope into four high-intensity days and six themes — Biotech, Investors, Replacement, Longevity Science, AI x Bio, Biostasis. Organized...
Clogged artery
A group of researchers, including Matthew O'Connor of Cyclarity Therapeutics, has published a review detailing what effects 7-ketocholesterol (7KC) has in the human body. An oxidized cholesterol 7KC, an oxidized cholesterol (oxysterol) gets its name from being oxidized at the C7 position within the cholesterol molecule [1]. This compound is formed by non-enzymatic processes driven...
New growth from old tree
A recent study published in Geriatrics debunks the assumption that an older chronological age results in an inevitable and universal decline in health. The researchers reported that a significant number of older adults who participated in the study experienced an improvement in cognitive and/or physical functioning [1]. Challenging the status quo Older age is known...
Cryogenics
In a new study, researchers have vitrified mouse brain slices and then a complete brain with encouraging results: upon rewarming, much of the neuronal function was preserved [1]. The bumpy road to cryopreservation Successful cryopreservation is a coveted prize in medicine, as cryopreserving organs and tissues can make transplantation more accessible. It is also a...