Matthew O'Connor

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Cynomolgus monkey
A recent study described a process called ferro-aging, in which iron accumulation leads to oxidative damage and cellular senescence. This process can be delayed by Vitamin C [1]. A two-faced atom Iron, like many components of biological systems, has two faces. On the one hand, it’s essential for developmental and metabolic processes [2, 3]. On...
Sauna
A new study shows that hitting a sauna for 30 minutes causes a transient spike in the number of circulating white blood cells. The researchers suggest that this exercise-like effect might provide health benefits by improving immune surveillance [1]. How does a sauna do its trick? Robust epidemiological data has associated sauna use with health...
Wrinkled skin
In Aging Cell, researchers have described how one dermal protein is related to maintaining the populations of fast-cycling skin cells and preserving skin integrity. Not all skin cells are the same The outer layer of the skin (the epidermis) is naturally regenerated by two distinct populations of stem cells: slow-cycling and fast-cycling [1]. The former...
2026 HLIS
The Asia-Pacific Longevity Medicine Society (APLMS), in partnership with The Kitalys Institute, announced that the 2026 Asia-Pacific Healthy Longevity International Summit (APAC-LMIS) will be held in Hong Kong from October 1–4, 2026, at the Hopewell Hotel. The Summit is expected to bring together more than 2,000 global leaders across longevity medicine, geroscience, pharmas, digital health, artificial...
Microglia among neurons
A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid β burden, improving cognitive abilities in a mouse model of Alzheimer’s. Drugs affecting this pathway are already available [1]. The unusual suspect In Alzheimer’s disease, many signaling pathways in the brain...
Drug combination
Researchers have found that simultaneously supplying NAD+ through NMN and reducing its loss through apigenin restores muscle function and bone structure to aged mice. A well-documented issue NAD+ is one of the most well-documented compounds in biology, including within the context of aging. Precursor supplementation has been repeatedly documented to have measurable benefits; for example,...