Matthew O'Connor

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Wrinkled skin
In Aging Cell, researchers have described how one dermal protein is related to maintaining the populations of fast-cycling skin cells and preserving skin integrity. Not all skin cells are the same The outer layer of the skin (the epidermis) is naturally regenerated by two distinct populations of stem cells: slow-cycling and fast-cycling [1]. The former...
2026 HLIS
The Asia-Pacific Longevity Medicine Society (APLMS), in partnership with The Kitalys Institute, announced that the 2026 Asia-Pacific Healthy Longevity International Summit (APAC-LMIS) will be held in Hong Kong from October 1–4, 2026, at the Hopewell Hotel. The Summit is expected to bring together more than 2,000 global leaders across longevity medicine, geroscience, pharmas, digital health, artificial...
Microglia among neurons
A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid β burden, improving cognitive abilities in a mouse model of Alzheimer’s. Drugs affecting this pathway are already available [1]. The unusual suspect In Alzheimer’s disease, many signaling pathways in the brain...
Drug combination
Researchers have found that simultaneously supplying NAD+ through NMN and reducing its loss through apigenin restores muscle function and bone structure to aged mice. A well-documented issue NAD+ is one of the most well-documented compounds in biology, including within the context of aging. Precursor supplementation has been repeatedly documented to have measurable benefits; for example,...
Human eye
The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials this year, things might be changing there. If this technique works in resetting the biological age of the human eye, the entire multibillion-dollar longevity industry could move to the center of...
Time-restricted eating
A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of the first and last meals is associated with faster aging [1]. Finding the right patterns and rhythms Chrono-nutrition is an approach that connects eating patterns, circadian rhythms, and health outcomes [2]....