Matthew O'Connor

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This month, a group of researchers published an annual report on the clinical trials that are testing drugs for Alzheimer’s disease. Overall, they reported an increase in the number of trials, with 158 drugs investigated across 192 trials [1]. A growing problem The projections regarding the prevalence of Alzheimer’s disease are merciless. While in 2017,...
AI for Practical Longevity
We are super excited to share with you that today we released AI4L - "AI for Practical Longevity", an open-source system that enables anyone to produce rigorous, evidence-based reviews of health and longevity interventions using frontier AI models. Our novel "Audit-Driven Prompting" method enables iterative self-auditing and eliminates hallucinations with live citation verification and zero-tolerance...
Muscle and fat
A new study suggests that GLP-1 receptor agonists do not affect muscle mass any more than weight loss caused by caloric restriction, and this appears to be true for strength as well [1]. What do we lose when we lose weight? GLP-1-based drugs, such as semaglutide and tirzepatide, have transformed obesity treatment. People on these...
Junyue Cao Interview
Dr. Junyue Cao is a professor at the Rockefeller University, and his lab develops ultra-high-throughput single-cell technologies and applies them to the biology of aging. In a recent paper published in Science, his team used a technique called EasySci-ATAC to profile chromatin accessibility in about seven million cells from 21 mouse tissues across three ages,...
Gut bacteria
In Aging Cell, researchers have elucidated the relationship between intestinal aging and age-related changes to the gut microbiome. Two interdependent biologies The human gut works through the interaction of two entirely different sets of cells. The first is the body's actual cells, including the intestinal barrier between the gut and the rest of the body,...
Creatine powder
In a new study, the popular supplement creatine seemed to add to some of the beneficial effects of power training [1]. Trying the combination in older people Exercise might be the most potent anti-aging intervention known to humans, but with age, building strength and muscle mass becomes harder. Also, not all types of exercise are...