Lifespan Research Institute

Matthew O'Connor

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Elderly Resistance Exercise
Using brain clock models that analyzed MRI images of the brains of elderly people who underwent one year of resistance training, researchers concluded that both heavy and moderate resistance training slow brain aging [1]. The broad benefits Exercise has been linked to many benefits, such as lowering blood pressure, slowing down cancer progression, preventing fitness...
Synapses
Scientists have discovered that ATP deficiency disrupts dopamine processing in synapses, leading to the accumulation of the harmful protein species that characterize Parkinson’s disease. ATP supplementation helps, but the road to the clinic might be long [1]. Parkinson’s and dopamine Parkinson's disease is defined by two hallmarks: the death of dopamine-producing neurons in a midbrain...
Rejuvenation Roundup February 2026
Plenty of crucial work has been done in the rejuvenation world over the past four weeks, and last month, we've spoken to several researchers about the progress being made. Interviews João Pedro de Magalhães on the Ethics of Longevity: João Pedro de Magalhães, professor at the University of Birmingham, is a skilled longevity advocate who...
Cells
Cellular reprogramming is one of the technologies most associated with longevity. The field was created in 2006, when Shinya Yamanaka showed that a cocktail of four transcription factors, commonly known as OSKM, can cause de-differentiation and massive rejuvenation of a cell, creating an iPSC (induced pluripotent stem cell). About a decade later, partial reprogramming was...
Gelatinous stem cells
Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities. Pinpointing the loss of function This paper begins by highlighting a core problem of using self-derived (autologous) stem cells for treatments in older people: the cells...
Joao Pedro de Magalhaes Interview
João Pedro de Magalhães, professor at the University of Birmingham, is known as a prominent geroscientist who has been in the field forever, enriching it with top-tier research. He is also a skilled longevity advocate who has long taken interest in the ethics of longevity, first offering his perspective as far back as 2003. Prof....