Matthew O'Connor

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DNA clock
A recent review discusses the development of biological aging clocks, their capabilities and limitations, the discoveries they enabled, and possible future developments in this area [1]. How do we measure aging? Developments in science and technology have allowed researchers to move beyond speculation and philosophical debates about aging to study its molecular underpinnings and the...
Situps
A new study suggests that regular planned exercise, not just being generally active, protects against certain aspects of muscle aging [1]. Are trained muscles younger? With age, skeletal muscles lose strength, metabolic flexibility, and mitochondrial capacity. While regular exercise slows many aspects of functional aging [2], just how deeply training affects the molecular state of...
Gabriel Cian Interview
In this follow-up interview, we speak with Gabriel Cian about how the 2060 ecosystem has evolved since last year’s Forum, what he learned from the first edition, and how he is thinking about investment, scientific credibility, health optimization, policy, and the future of longevity in Europe. Last year, we spoke about your path from software...
Human liver
Researchers have described a method of using exosomes derived from mesenchymal stem cells (MSCs) to fight harmful metabolic changes in the liver. Another look at exosomes This is far from the first attempt at using MSC-derived exosomes, particularly exosomes derived from MSCs originally taken from human umbilical cord tissue (HucMDEs derived from HucMSCs), to treat...
E Coli
Scientists have engineered an enzyme that removes an advanced glycation end product (AGE) from proteins. This type of age-related modification, which affects protein function and can trigger inflammation, has previously been considered extremely hard to reverse [1]. Can we rejuvenate proteins? Many proteins are continually broken down and replaced. Others, especially proteins of the extracellular...
The thymus
Publishing in Aging Cell, researchers have devised a way to delay the aging of the thymus by targeting GPR40, a key receptor in its epithelial cells. The organ that involutes The thymus trains a certain subset of immune cells, which are named T cells due to their relationship with it. As the thymus ages, its...