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Matthew O'Connor

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The Short Peptide Elamipretide Delays Ovarian Aging in Mice

A recent study showed that a treatment with the short peptide elamipretide reversed multiple signs of age-related decline in oocyte quality in mice and in human oocytes in vitro [1]. An early decline In females, the reproductive system ages relatively early in life, with fertility declining as early as the mid-thirties; combined with the recent...

A Supplement Kills Senescent Cells and Extends Life in Mice

A new study shows healthspan and lifespan increases in male mice following late-life treatment with vanadyl sulfate, a food-derived molecule marketed as an over-the-counter supplement [1]. Searching for vulnerabilities Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead,...

Inflammaging and Poor Sleep Contribute to One Another

After a review of substantial literature, scientists publishing in Aging Cell have concluded that poor sleep quality and inflammaging worsen each other in a vicious cycle, reducing quality of life and fueling other age-related diseases. More than a peripheral link Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into...
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Longevity Supplement Improved Blood Vessels in a Human Trial

In a clinical trial, the supplement NOVOS Core was associated with significant improvements in artery function and systolic blood pressure. It is unknown which particular ingredients are responsible for the effect [1]. To the Core of the matter Led by Christian Heiss, Professor of Cardiovascular Medicine, researchers at the University of Surrey put NOVOS Core,...
Editorial 16-9

Momentum on Two Fronts for Rejuvenation

This month has been marked by progress in both the regulatory and investment sides of rejuvenation biotechnology. For years, the field has faced two major challenges: scientific advances outpacing the regulatory systems meant to evaluate them, and a capital environment that has often struggled to distinguish serious translational work from noise and hype. Fortunately, recent...

Why Male Mice Lose Anti-Cancer Immunity Earlier

A new study found that shrinking reserves of naive T cells weaken tumor recognition in male mice by middle age more than in females. Restoring thymic activity improved protection [1]. Do men lose anti-cancer defenses with age? CD8+ T cells are immune cells that can kill infected or cancerous cells. However, an individual T cell...
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