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Matthew O'Connor

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Pathway forward

Harvard Publishes a Longevity Report for the General Public

The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age and entering the mainstream. People do want to live longer From time to time, Harvard Health Publishing issues Special Health Reports – consumer-facing, doctor-reviewed guides translating medical research for...
DNA modeling

A Better Algorithm for Predicting How Cells Behave

In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells' gene expression will respond to interventions. The need for prediction Simulating biological processes on a computer is an incredibly difficult task. While advanced algorithms such as Google's AlphaFold have revolutionized protein folding,...
Lung cancer tumor

Early Cancer Cells Change Their Surroundings to Form Tumors

Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. Understanding this can inform future early-stage cancer therapies [1] Cancer is a disease of aging. With the exception of childhood cancers, most of which stem from inherited genetic errors, adult cancers tend to occur later in...
Heart examination

Cardiovascular Health During the Menopausal Transition

A recent study compared premenopausal, perimenopausal, and postmenopausal women’s cardiovascular health. Perimenopausal women had about twice the odds of having a poor overall score when compared with premenopausal women, after adjusting for age [1]. Menopausal health decline The menopausal transition, and the associated changes in hormonal levels, especially declining estrogen levels, mark not only the...
Brain

Tau Protein Is Crucial for Encoding Long-Term Memory

Scientists have uncovered an unexpected function of the tau protein, which is mostly known for its role in Alzheimer’s and related disorders: helping encode long-term memory. This can inform novel approaches that target tau [1]. In sickness and in health Tau is a protein found mainly in neurons, where its textbook job is to bind...
Omega 3 foods

How Omega-3 Fatty Acids May Alleviate Kidney Disease

Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Previous mixed results Several clinical trials have found that taking omega-3 PUFAs has benefits for older people. One study found that it reduces the rate of aging according to epigenetic clocks [1], while...
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