Matthew O'Connor

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Gabriel Cian Interview
In this follow-up interview, we speak with Gabriel Cian about how the 2060 ecosystem has evolved since last year’s Forum, what he learned from the first edition, and how he is thinking about investment, scientific credibility, health optimization, policy, and the future of longevity in Europe. Last year, we spoke about your path from software...
Cells versus cells
A new study associated with Immorta Bio suggests that combining a senolytic vaccine with mesenchymal stem cells might create a synergistic impact. However, the findings rest on acute, artificially induced injury models rather than natural aging [1]. Clearing out senescent cells to help stem cells work Mesenchymal stem cell (MSC) therapies have largely underperformed in...
Underground laboratory
A perspective published in Aging and Disease has recommended the use of underground laboratory space in order to remove the effects of surface radiation on biological clocks. A question of entropy The cascading failure of bodily systems, leading to the loss of organ function, sits downstream of fundamental damage to genomics and epigenomics. However, how...
Protein-Rich Diet
In a recently published perspective paper, the author argues that the UK's official health guidelines on physical activity and protein intake should be revised to recommend levels necessary to achieve optimal health, rather than the bare minimum currently recommended [1]. From bare minimum to optimizing for healthspan Current government guidelines on nutrition and physical activity...
Scientists have linked disrupted Ca²⁺ homeostasis to aging in both progeroid and naturally aging mice. Rescuing it with a well-known antidepressant significantly increased the animals’ median and maximum lifespan [1]. Calcium ions in progeria and natural aging Cells use calcium ions (Ca²⁺) for signaling, and a rise or fall in cytoplasmic Ca²⁺ switches many pathways...
Man with dumbbell
Researchers have elucidated some of the links between the age-related loss of muscle (sarcopenia) and the age-related loss of bone (osteoporosis). Related in multiple ways Substantial previous research has described the relationship between muscle and bone health. While misloading can be dangerous, ordinary mechanical loading, which necessarily involves muscle use, maintains the density of bone...