Matthew O'Connor

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Gut bacteria
A new study highlights a fatty acid produced by a particular genus of bacteria as a “natural statin,” suggesting a new way of treating atherosclerosis [1]. Bacteria and cholesterol Atherosclerosis develops when cholesterol-rich particles accumulate in arterial walls, driving inflammation and plaque buildup. The liver helps mitigate this process by removing low-density lipoprotein (LDL), which...
Proteins or extracellular vesicles
In Aging, researchers have described the differences between the secretions of cells driven senescent through a cancer gene and cells that stopped proliferating due to p16 expression. A difference of kind Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...
Forever Healthy Foundation
With more than 860 evidence reviews on health and longevity interventions, Evipedia is now probably one of the deepest online sources in this area. We have always been extremely open to sharing our data and making it accessible in any form that supports projects and tools that enable people to make better decisions about their...
Cell and organelles
A new study links an age-related decline in cellular maintenance to impaired immune clearance. Activating the pathway reduced signs of senescence in aged mice [1]. Senescence and autophagy Cellular senescence, which occurs when cells stop dividing and start emitting largely pro-inflammatory stress signals, the senescence-associated secretory phenotype (SASP), is a double-edged sword. On the one...
Brain and walking
Researchers have discovered key biomarkers that are strongly linked to all-cause mortality and identified four measurements with independent predictive power. Biological versus chronological This paper opens with a discussion of a familiar fact for people interested in living longer: one's biological age is not the same as one's chronological age [1]. Biological age gives a...
FDA at ARDD
At a panel in Boston, senior officials announced plans to include aging in the agency’s regulatory science agenda and discussed how therapies could move toward approval. Longevity has a partner The 2026 edition of the Aging Research and Drug Discovery Meeting (ARDD) kicked off yesterday. This is one of the biggest and longest-running longevity conferences,...