Matthew O'Connor

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Rejuvenation Roundup June 2026
Doing something about aging seems to require action at the most basic genomic level. Here's what's been done there and in other areas in June. Interviews The Thalion Initiative: A New Non-Profit With Big Ambitions: The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite...
Drug compartments
A new study suggests a way to predict whether existing drugs can extend human lifespan. This method uses a network approach that detects longevity signals in protein interactions [1]. Slowing aging with existing drugs? Finding drugs that can slow aging, a multifactorial process involving thousands of genes, is hard. Directly measuring the effect of a...
Monkeys and people
Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs) do not themselves produce proteins, they serve crucial regulatory functions. Short ncRNAs, such as microRNAs, are involved in the fine-tuning of transcriptional pathways, modulating the proteins produced by coding...
Organs
A new study has used aging trajectories of various cell types to predict diseases such as Alzheimer’s and lung cancer [1]. This expands on previous research into organ-specific aging. Age is more than one number Gone are the days when aging was assumed to be happening uniformly across every tissue at once. Today, we know...
Knee pain
Researchers have found that sustained expression of excess hypoxia-inducible factor (HIF)-1α leads to unwanted formation of blood vessels (angiogenesis) that destroys cartilage and causes osteoarthritis. A necessary but destructive factor Being required for extracellular matrix (ECM) construction and energy in the absence of oxygen, HIF-1α is necessary for cartilage-building cells (chondrocytes), which normally live in...
Younger 2027
NeuroAge Therapeutics announced Younger 2027, a six-month biological aging contest in which competitors are measured on a clinical-grade aging panel and retested six months later. Baseline testing kits begin shipping September 1, 2026, with at-home baseline testing open through February 1, 2027. A live kickoff conference open to competitors and the broader longevity community takes...