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Matthew O'Connor

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Serotonin Signals Suppress Physical Activity in Aging Mice

A new study has found that increased production of serotonin by neurons in a particular brain region inhibits dopamine production and willingness to move, causing loss of activity. Killing serotonin-producing neurons reversed the effect [1]. Can’t or won’t? Physical activity tends to decline with age. As with many manifestations of aging, we tend to think...

A New Target for Fighting Tau Tangles in Neurons

Researchers have found that HDAC7 bridges together GSK3β and hyperphosphorylated tau protein (hTau) in neurons, which may spur Alzheimer's disease. Getting rid of HDAC7 in hTau model mice ameliorated their cognitive decline. How proteins go wrong Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation...

The Short Peptide Elamipretide Delays Ovarian Aging in Mice

A recent study showed that a treatment with the short peptide elamipretide reversed multiple signs of age-related decline in oocyte quality in mice and in human oocytes in vitro [1]. An early decline In females, the reproductive system ages relatively early in life, with fertility declining as early as the mid-thirties; combined with the recent...

A Supplement Kills Senescent Cells and Extends Life in Mice

A new study shows healthspan and lifespan increases in male mice following late-life treatment with vanadyl sulfate, a food-derived molecule marketed as an over-the-counter supplement [1]. Searching for vulnerabilities Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead,...

Inflammaging and Poor Sleep Contribute to One Another

After a review of substantial literature, scientists publishing in Aging Cell have concluded that poor sleep quality and inflammaging worsen each other in a vicious cycle, reducing quality of life and fueling other age-related diseases. More than a peripheral link Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into...
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Longevity Supplement Improved Blood Vessels in a Human Trial

In a clinical trial, the supplement NOVOS Core was associated with significant improvements in artery function and systolic blood pressure. It is unknown which particular ingredients are responsible for the effect [1]. To the Core of the matter Led by Christian Heiss, Professor of Cardiovascular Medicine, researchers at the University of Surrey put NOVOS Core,...
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