Lifespan Research Institute

Matthew O'Connor

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Vaccine
An analysis of over 3800 older adults found that shingles vaccination is associated with lower inflammation scores, slower epigenetic and transcriptomic aging, and a lower composite biological aging score [1]. Beneficial side effects Vaccines are developed to prevent specific diseases, such as polio, measles, hepatitis, and many others. However, recent data suggest that some adult...
Rapamycin molecule
A new study from the Universities of Oxford and Nottingham has uncovered a potential new mechanism by which rapamycin counters immunosenescence. Rather than increasing autophagy or reducing protein synthesis, the effect appears to involve directly reducing DNA damage burden in immune cells [1]. How can this work? Rapamycin, a powerful inhibitor of the nutrient-sensing mTOR...
Placenta concept
Researchers publishing in Aging Cell have discovered that cells derived from the human placenta may be useful in estimating the effects of potential anti-aging treatments. A seemingly odd choice Of all the organs in the body, the placenta may be the least concerning with regards to aging; it only exists for at most 10 months,...
Outdoor exercise
A new study links exercise variety, defined as regularly engaging in several types of physical activity, to significantly lower all-cause mortality. Exercise amount matters as well, but the effect plateaus quickly [1]. How exactly is it good for you? “Exercise is good for you” is a stale truism, but researchers continue to uncover new information...
Synapses
Resesarchers have found that thrombospondin-1 (TSP-1), a compound that is critical in growing brain synapses, is secreted by normal astrocytes but not senescent ones. Senescence is harmful to the brain Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
LWF
The Longevity World Forum announces its move to Madrid, reinforcing its international positioning with a new location aligned with its growth and leadership objectives in the field of longevity science and healthy ageing. The Spanish capital beats the cities that were postulated as possible venues for the next edition and thus adds an important asset...