Matthew O'Connor

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Longevity Science Foundation
Driven by ongoing support from their community, The Longevity Science Foundation is extending the deadline for the Invested in Her campaign to October 1, 2026, as they work toward a $250,000 fundraising target to support early-stage research into ovarian aging and menopause. Hundreds of millions of women live longer than men yet spend more years...
Rejuvenation Roundup August 2026
Properly untangling aging means untangling its various counterbalances, sometimes on the individual level. Here's what's been investigated this month. Interviews Wei-Wu He: People Should Become the CEOs of Their Own Health: Wei-Wu He is an unusual combination of scientist and businessman, and his current company focuses on using precision medicine to lengthen people's lives. Michael...
Chromatin
Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. When DNA modifies itself Long interspersed elements-1 (LINE-1) have existed in organisms' genomes, including our own, for well over a billion years [1]. They are the only autonomous elements...
Michael Snyder Interview
Michael Snyder, Director of the Center for Genomics and Personalized Medicine at Stanford University, is obsessed with health-tracking wearables. During our interview, he wore four wrist-worn devices – watches and bands – and two rings. He is convinced that these small but powerful gadgets will help drive the transition from today’s “sickcare” to true healthcare,...
Aggressive cancer
A recent study has examined whether senescence might allow cancer cells to survive oncogene withdrawal and become even more dangerous [1]. Some blocking techniques are temporary Many cancers depend heavily on a particular oncogenic signal to maintain their growth. Drugs that block these drivers can, therefore, produce dramatic tumor shrinkage. A major clinical problem, however,...
Bicycle racers
A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. long and moderate Exercise is a well-known lifestyle factor that can positively impact health. Exercise benefits multiple cells,...