Matthew O'Connor

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Proteins under magnifying glass
Researchers have established how a protein that is nearly absent in the literature, PTCHD4, is linked to cellular senescence. Very little previous work In most papers, after a customary discussion of the mechanics of cellular senescence and current methods of handling it and its repercussions, the researchers go on to discuss previous work relating to...
Neurons
A team of researchers has discovered that mitochondrial health and location may be critical to why cognitive plasticity decreases with age. Old mammals and new tricks The adage 'you can't teach an old dog new tricks' is true across a wide variety of organisms; neural plasticity decreases with age in rodents, non-human primates, and people...
Lung inflammation
Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib. This suggests possible anti-aging effects, but separating those from the narrower benefits of treating fibrosis remains a challenge [1]. The AI-developed drug Many drugs developed for particular diseases act on aging-related biological processes. That creates an opportunity: a...
Grok Bot
With Grok Bot, SpaceXAi has created something really special and helpful. And the Evipedia Grok Bot turns this gem into something even more precious. A specialized AI assistant offering an evidence-based 2nd opinion on health and longevity interventions. It integrates Grok, the AI4L persona, the Evipedia MCP server, and Evipedia-hosted search into one super-useful companion. What Evipedia Grok Bot will do for...
LSM 1
Fresh from Spain’s spectacular victory in the 2026 FIFA World Cup, Madrid is preparing for another kind of world-class gathering: one focused not on winning more years of sporting glory, but on winning more healthy years of life. On September 30 and October 1, 2026, the International Longevity Summit Madrid 2026 will bring together leading...
Weak muscles
Researchers have discovered and explained how calcium mishandling in muscle cells leads to long-term muscle weakness in older people. Calcium is not just for bones Skeletal muscle cells use calcium ions to control how and when they contract. This activity is modulated by CaMKII, a protein kinase that also regulates muscle adaptations in response to...