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Matthew O'Connor

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Microglia attacking a neuron

In ALS, Microglia Eat Living Neurons, Mistaking Them for Dead

A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1]. The living dead Amyotrophic lateral sclerosis (ALS), an age-related neurodegenerative disease, is characterized by the progressive loss of motor neurons. Historically, much of ALS...
Fat cells

How Old Fat Cells Trigger Inflammation and Raise Risks

Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Too much of a regulator leads to dysregulation Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles...

GenBio Launches a “Virtual Cell” AI Model

This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to successive perturbations, potentially transforming biological research. Living in a simulation Simulating a living organism on a computer (in silico) has been a dream of both...
Brain cell types

How Senescence Spreads Between Brain Cells

Researchers have gone into deep detail regarding how each of five senescent brain cell types expresses and receives factors that encourage other cells to become senescent. The contagion of age Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
No getting fat

A Million-Person Study Finds a Protective Metabolic Gene

A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1]. Longevity hidden in the genome For decades, aging researchers have hoped that human genetics might reveal genuine “longevity genes” whose altered...
Three Against Cancer

A Drug Combination Fights Both Senescence and Cancer

In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
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