Matthew O'Connor

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A new study identified two polyunsaturated fatty acids, α-eleostearic acid (α-ESA) and α-ESA methyl ester (α-ESA-me), that showed senolytic activity in cell cultures and a mouse model [1]. An anti-aging strategy Cellular senescence is one of the most critical aging-related processes. Senescent cells, which accumulate with age, are arrested in the cell cycle and are resistant...
BioAge Labs
BioAge Labs, Inc. ("BioAge”, "the Company"), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging, today provided financial results for the full year ended December 31, 2025 and business updates for the fourth quarter ended December 31, 2025. "The past few months have been a defining...
Immune cell in living tissue
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher efficacy across three cancer types, including a solid tumor [1]. CAR T therapies: promising but imperfect Ideally, T cells, the killer cells of our adaptive immune systems, should...
Healthspan Horizons
The Buck Institute for Research on Aging today announced the launch of Healthspan Horizons, a new initiative designed to address one of the most urgent challenges in modern medicine: how to measure, understand, and extend healthspan—the years of life spent in good health. People are living longer—but too many of those added years are spent managing...
NOVA 2026
For the first time, the Neuroscience of Vitality and Aging (NOVA) Conference is bringing together leaders from across neuroscience, biotechnology, policy, and investment to examine one of the most urgent questions in medicine today: how to preserve brain health across the lifespan and accelerate progress against neurodegenerative disease. Hosted by the Aging Initiative, a nonprofit...
Horoscope prescription
Imagine this pitch: a simple cheek swab or blood spot mailed from home tells you not your birthday but your “true” biological age - the number that supposedly reflects your real health trajectory. Patients increasingly walk into clinics clutching these reports, convinced they’ve discovered the secret to their future. It’s an appealing idea. Aging is...