Related Organizations
Articles from this author
March 12, 2026
A group of researchers, including Matthew O'Connor of Cyclarity Therapeutics, has published a review detailing what effects 7-ketocholesterol (7KC) has in the human body. An oxidized cholesterol 7KC, an oxidized cholesterol (oxysterol) gets its name from being oxidized at the C7 position within the cholesterol molecule [1]. This compound is formed by non-enzymatic processes driven...
March 09, 2026
The European Heart Journal has published a review of what happens to the human heart as it ages, noting the cellular effects of mitochondrial dysfunction and cellular senescence along with more visible changes such as hypertrophy and fibrosis. A constantly working organ The reviewers begin this paper by noting the constant work of the heart,...
March 05, 2026
Researchers publishing in Aging Cell have discovered how older organisms' susceptibility to pneumonia is related to inflammatory factors. Short-lived infection fighters Polymorphonuclear leukocytes, more commonly known as neutrophils, are part of the first line of defense against lung infections. Illnesses cause these immune cells to be recruited from the bone marrow in a process called...
February 26, 2026
Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities. Pinpointing the loss of function This paper begins by highlighting a core problem of using self-derived (autologous) stem cells for treatments in older people: the cells...
February 23, 2026
In Aging Cell, researchers have explained how the sirtuin SIRT6 protects against proteostasis-related brain disorders by maintaining the function of nucleoli and limiting protein production. The nucleus and nucleoli Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of...
February 19, 2026
Researchers publishing in Aging have used Mendelian randomization to conclude that the inflammatory factor IL6 causes increased mortality and that its circulating receptor, IL6R, decreases it. Looking for a proof of danger Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection...