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August 11, 2025
In Aging, researchers have reported on how an increase in FGF21, a myokine that encourages muscle growth, impacts the progression of amyotrophic lateral sclerosis (ALS). Progressive and fatal ALS is an age-related disease that is characterized by the degeneration of motor neurons throughout the spinal cord and in the brain, leading to death by respiratory...
August 07, 2025
Researchers have found that growing older cells in a youthful medium causes them to behave and function more like younger cells, suggesting a new method of creating stem cell-based therapies. Cultivating patient-derived cells For some time, mesenchymal stem cells (MSCs), which can be used to differentiate into multiple functional cell types, were thought to be...
August 04, 2025
Researchers have developed a transcription-based clock that estimates brain age and used it to identify potential interventions against age-related neurodegeneration. Deciding which -omic to use While neurodegeneration and brain aging are not precisely the same [1], the two are tightly linked [2]. Substantial previous work has found that directly addressing brain aging in multiple forms,...
July 31, 2025
Researchers publishing in Nature Aging have discovered how Alzheimer's-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain Why We Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of...
July 28, 2025
In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work has found a strong link between obesity and osteoarthritis of the knee [1]. While the increased weight itself may be a factor, fatty acids themselves...
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH), which occurs when stem cells create large numbers of cells with the same mutation, is linked to blood cancers [1]. DNMT3A is the most commonly...