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February 19, 2026
Researchers publishing in Aging have used Mendelian randomization to conclude that the inflammatory factor IL6 causes increased mortality and that its circulating receptor, IL6R, decreases it. Looking for a proof of danger Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection...
February 16, 2026
Researchers have found that altering a growth hormone receptor in the brain adipose tissue of aged male mice slows their mental aging and allows them to perform far better on cognitive tests. Growth signaling is not necessarily good The axis of growth hormone and insulin-like growth factor 1 (IGF-1) is well-known in aging, and the...
February 12, 2026
A team of researchers has biologically engineered T cells with currently available Alzheimer's drugs in order to directly attack the characteristic amyloid plaques of Alzheimer's disease. Building on the current paradigm Most Alzheimer's treatments used in the clinic are -mabs, monoclonal antibodies that are designed to attack the amyloid beta plaques that accumulate in the...
February 09, 2026
In Aging Cell, researchers have described why older natural killer (NK) cells lose their ability to eliminate harmful cells and a potential treatment for this decline. Judgment and ability At the cellular level, there is no due process. Natural killer (NK) cells judge other cells' guilt or innocence by their surface proteins. They ruthlessly exterminate...
February 05, 2026
Researchers publishing in Nature Aging have described how mitochondrial stress is a key part of why senolytics are effective. Finding targeted effectiveness What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apoptosis and cling onto life. One of the challenges in dealing with...
January 29, 2026
In Nature Communications, researchers have described how small extracellular vesicles (sEVs) fused with plasma membrane proteins successfully treated heart arrhythmia in a rat model. Why do people need pacemakers? In a healthy heart, the sinoatrial node (SAN) serves as a natural regulator, commanding the heart to regularly contract. As it becomes dysfunctional and fibrotic with...