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October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping cells healthy Why We Age: Disabled MacroautophagyIn autophagy, damaged proteins and organelles are wrapped in a double-membraned autophagosome structure. These sacs then join with lysosomes,...
October 27, 2025
A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular senescence are both well-known aspects of aging. The cross-linked collagens, such as glucosepane, that lead to a less-flexible ECM accumulate with time and have long been the subject of...
October 23, 2025
Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, are useful in determining the biological ages of dogs. The Dog Aging Project With enrollment beginning in 2020, the Dog Aging Project (DAP) is an initiative to study canine aging [1], and...
October 20, 2025
In Cell Stem Cell, researchers from the Cedars-Sinai Medical Center have published a review discussing what experiments conducted in space can do for stem cell research and medical research as a whole. Cells behave differently in microgravity The gravitational effects of freefalling in orbit are very difficult to properly simulate on Earth, making this the...
October 16, 2025
Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the brains of age-accelerated mice by improving lymphatic drainage. Gunking up the works Advanced glycation end-products (AGEs), like their acronym suggests, accumulate with age. These substances, which are formed when sugars bind to other molecules without the assistance of enzymes, drive multiple...
October 13, 2025
In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging. Looking for signals in the noise Introducing their study, the researchers note that gene expression changes are difficult to interpret because they occur across a panoply of genes and the strongest...