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Tag: Oct-4

March 13, 2020
Today, we are going to take a look at the companies working on resetting cellular aging through a reprogramming approach that directly targets a core reason we age. Cellular reprogramming resets aging in cells As we age, our cells experience alterations to their epigenetic markers, and this, in turn, changes gene expression; this process is...
November 08, 2019
A recent open-access study published in Cell Stem Cell has shown that excluding Oct4 from the OSKM cocktail reduces epigenetic aberrations and off-target gene activation. Induced pluripotency and Yamanaka factors Pluripotent stem cells are cells that can become other cell types in the body; during natural development, they create differentiated stem cells and ultimately somatic...
August 16, 2019
A new study outlines multiple ways in which epiblast stem cells can be reprogrammed back into a fully pluripotent state, paving the way for a better understanding of epigenetics. The role of epigenetics Epigenetics are why our cells, which all have the same DNA, differ in function. A bone cell has the same genetics as...
March 20, 2019
We have talked about the potential of partial cellular reprogramming in previous articles, and today, we want to draw attention to a new paper that promises to further refine reversal of epigenetic aging in cells. As we age, our cells experience alterations to their epigenetic markers, and this changes gene expression, which is proposed to...