Tag: Obesity

A team of researchers has waded into a controversial and contradictory area of study, publishing information on the link between obesity and an inflammatory molecule that increases with aging. A context-dependent molecule What is Inflammaging? Chronic Inflammation and AgingOne of the aging processes consists of a chronic, smoldering background of inflammation that researchers call “inflammaging”.Read...

A new study suggests that the reason why aging is associated with obesity lies in specific neurons found in the brain [1]. Tell that to the brain It is often hard to lose weight, and it becomes harder with age. While it seems simple enough to eat less, signals in the brain are telling people to...

According to a paper published in Aging, a fisetin derivative that is being investigated for brain protection may also be effective in controlling glucose and ameliorating obesity. Repurposing a repurposed compound CMS121, the focus of this study, was created by modifying fisetin, a flavonol that is well known for its effects against cellular senescence. CMS121...

In GeroScience, researchers have described how turning off a specific protein prevents mice from getting obese in old age. Mimicking hypoxia Hypoxia-inducible factors (HIFs) are a collection of three proteins that are sensitive to oxygen, and, like their name suggests, they normally activate when a cell is operating in a low-oxygen environment. The gene EGLN1...

A group of Japanese researchers has published a paper reporting an association between higher abdominal fat levels and cognitive decline [1]. Abdominal fat and brain connection Aging is often linked to many comorbidities, one of which is dementia, and developing drugs to treat this condition is challenging. An alternative, more immediately feasible approach is to...

A new review summarizes our knowledge about lifestyle interventions, such as exercise, healthy diet, and good sleep, that can possibly reduce cellular senescence [1]. What do we do with a senescent cell? Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues...