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Tag: mTORC1

Dividing cell
Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells proliferate and become active muscle tissue (myogenesis) [1]. Another piece of the puzzle We have recently reported on the effects of mitochondrial fusion and fission...
Duchenne
A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. A genetic disease with hallmarks of aging Duchenne muscular dystrophy is caused by a mutation that gradually destroys the muscles, eventually becoming fatal as it destroys the diaphragm or...
Many lab mice
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in muscle tissue. The role of mTORC1 Mammalian target of rapamycin complex 1 (mTORC1) is a well-known component of fundamental nutrient sensing pathways whose dysregulation is...
Psoralea corylifolia
A new publication in Nature Communications has revealed that corylin, which is derived from the Chinese herb Psoralea corylifolia, increases the lifespan of model organisms through well-known pathways of aging. Finding corylin This study did not begin with an examination of corylin or even a look at this particular herb. Instead, the researchers examined multiple...
Easter Island
We take a look at rapamycin and why some researchers think it could be useful in combating aging. What is rapamycin? Rapamycin is a macrolide, a class of antibiotic that includes erythromycin, roxithromycin, azithromycin, and clarithromycin. Rapamycin exhibits potent antitumor and immunosuppressive activity. Where is rapamycin found? Rapamycin was first discovered in 1972 in the...
Three Baby Mice
A study published in Cell Reports has shown that early-life exposure to antibiotics that destroy the gut flora can harm the lifelong development of mice, including lifespan. Three groups with different microbiota To begin the study, the researchers fed 20 baby mice, as well as their mothers, amoxicillin and neomycin, and they established a control...

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