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Tag: Interventions Testing Program

Pink salmon
Scientists in the Intervention Testing Program have found that the antioxidant astaxanthin and the seasickness medication meclizine, both sold over the counter, significantly extend median lifespan in mice [1]. Astaxanthin and meclizine are in, but fisetin is out The Intervention Testing Program (ITP) has existed for about 20 years, and it is considered the gold...
Animal husbandry
A team of researchers, including Matt Kaeberlein and Brian Kennedy, has published a preprint discussing the necessity of using long-lived animals in life extension research. The Interventions Testing Program (ITP) uncovers weaknesses The ITP is run by the National Institutes of Aging and described by these researchers as being rigorous and a gold standard. Its...
RNA strand
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1]. Global changes It is well known that aging is accompanied by changes in the expression of many genes. Therefore, numerous studies have focused on identifying...
Multiple drugs
In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1]. Anti-aging agent testing Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity...
Lab mice
Scientists have found that canagliflozin, an anti-diabetes drug that is known to extend lifespan in mice, alleviates an array of age-related pathologies, albeit in males only [1]. Anti-diabetes and anti-aging Canagliflozin, a widely used anti-diabetes drug, belongs to the class of sodium glucose cotransporter 2 (SGLT2) inhibitors, which regulate glucose reabsorption by the kidneys. Recently,...
Richard Miller
Richard A. Miller is a Professor of Pathology at the University of Michigan and the Director of Michigan's Paul F. Glenn Center for Biology of Aging Research. He is also a driving force behind the ITP, the Interventions Testing Program, created in the early 2000s to study the effect of various drugs on lifespan in...