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Tag: GrimAge

Depression can potentially accelerate aging.
April 22, 2021
People with major depressive disorder may have a biological age as much as two years greater than their chronological age, according to a new study [1]. The discovery provides a first step towards understanding the biological mechanisms that link depression to decreased lifespan. A link between depression and aging Depression is a serious global problem....
Steve Horvath at Ending Age-Related Diseases 2020
December 01, 2020
Dr. Steve Horvath is very well known in the field for his groundbreaking work on epigenetic clocks, which use one of the hallmarks of aging, epigenetic alterations, in order to calculate biological age. In his talk at Ending Age-Related Diseases 2020, he discussed how such clocks can be used to evaluate the effectiveness of rejuvenation...
Death clock
November 26, 2020
A new study published in the Journals of Gerontology has shown that the epigenetic clock GrimAge is a strong predictor of the effects of aging, particularly all-cause mortality: the likelihood of dying from any cause. Did previous clocks use the wrong target? As the researchers explain, the first-generation epigenetic clocks of Drs. Horvath (who contributed...
July 22, 2020
Reason, author of the anti-aging blog Fight Aging and CEO of Repair Biotechnologies, still isn't convinced that methylation is very useful in assessing biological age or the efficacy of various therapeutics, despite the wide use of methylation-based clocks. He surprised me at this year's Longevity Therapeutics conference in San Francisco by speaking out about the...
Death clock
February 25, 2020
Recently, researcher Dr. Alexey Moskalev has published a mini review that takes a look at aging biomarkers and how some of them compare with each other [1]. A major challenge in developing therapies that target the aging processes in order to prevent or reverse age-related diseases is having accurate ways to determine if a therapeutic...