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Tag: GrimAge

Steve Horvath at EARD2021
In his talk at Ending Age-Related Diseases 2021, Steve Horvath discussed a cytosine-based, pan-mammalian epigenetic clock that works across a wide variety of species. He also discussed how several of the hallmarks of aging do not seem to have any effect on epigenetic alterations.  Script Hello, thank you for your interest. My name is...
Elderly woman drinking alcohol
A study funded by the National Institutes of Health has found that excessive alcohol consumption increases the epigenetic age of non-Hispanic White women according to the GrimAge epigenetic clock. Why we Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and...
Depression can potentially accelerate aging.
People with major depressive disorder may have a biological age as much as two years greater than their chronological age, according to a new study [1]. The discovery provides a first step towards understanding the biological mechanisms that link depression to decreased lifespan. A link between depression and aging Depression is a serious global problem....
Steve Horvath at Ending Age-Related Diseases 2020
Dr. Steve Horvath is very well known in the field for his groundbreaking work on epigenetic clocks, which use one of the hallmarks of aging, epigenetic alterations, in order to calculate biological age. In his talk at Ending Age-Related Diseases 2020, he discussed how such clocks can be used to evaluate the effectiveness of rejuvenation...
Death clock
A new study published in the Journals of Gerontology has shown that the epigenetic clock GrimAge is a strong predictor of the effects of aging, particularly all-cause mortality: the likelihood of dying from any cause. Did previous clocks use the wrong target? As the researchers explain, the first-generation epigenetic clocks of Drs. Horvath (who contributed...
Reason, author of the anti-aging blog Fight Aging and CEO of Repair Biotechnologies, still isn't convinced that methylation is very useful in assessing biological age or the efficacy of various therapeutics, despite the wide use of methylation-based clocks. He surprised me at this year's Longevity Therapeutics conference in San Francisco by speaking out about the...