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Tag: Collagen

Hair Loss
Last week, a new study published in Aging reported similar mechanisms of TGF-ß2 and collagen on hair follicle aging, dermal papilla cell senescence, and in vitro spheroid formation. Aging hair follicles Hair follicles reside in the epidermal and dermal skin layers. At their base is the dermal papilla, where hair growth is controlled by dermal...
Blood cells in an artery
Today, we want to highlight the results of a recent long-term study, which collected data over a four-year period to investigate the link between aortic stiffening and cognitive decline, including dementia. During aging, our blood vessels become increasingly stiff and lose their flexibility, and the cells comprising it struggle to contract and relax properly. Blood...
Alexander Fedintsev
At Ending Age-Related Diseases 2020, Dr. Alexander Fedintsev of the Institute of Biology at Komi Science Center gave a talk about collagen glycation. Cross-links caused by advanced glycation end-products such as glucosepane stiffen the extracellular matrix, leading to systemic problems. Dr. Fedintsev provides evidence showing that the stiffened ECM leads to stem cell depletion, cellular...
Interview with Alexander Fedintsev
Two researchers, Alexander Fedintsev and Alexey Moskalev, have published an expansive review paper in which they propose a new hallmark of aging [1]. The authors draw our attention to a phenomenon that is sometimes overlooked in the context of aging: the accumulation of damage to long-lived molecules caused by the non-enzymatic chemical reactions of glycation,...
Collagen
Some pleasant news has recently arrived: Revel Pharmaceuticals has successfully completed a seed round in order to begin developing therapeutics that target glucosepane crosslinks, which are a proposed reason why we age, develop diseases such as diabetes, and suffer from stiffened arteries and hypertension. In the business of startups, a seed round refers to a...
Rapamycin skin
The results of a small human clinical trial focused on skin aging have been published, and they are positive. A topical application of rapamycin, an FDA-approved drug that is used to combat organ rejection during donor transplants and targets the mechanistic target of rapamycin (mTOR) pathway, was tested to see if it had any effect...