Tag: Cellular Senescence

A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on the cell cycle phase at which the senescent cell was arrested [1]. A personalized approach Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not...

In Aging Cell, researchers have reported that chromatin demethylation allows SASP compounds to be more easily expressed. Chromatin and gene expression Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical...

Researchers publishing in Nature Aging have discovered how Alzheimer's-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain Why We Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of...

Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning is normal During brain development, the resident immune cells of the brain (microglia) prune unneeded synapses as a form of maintenance. This is normally a...

Researchers have discovered how and why α-ketoglutaric acid (AKG) affects cellular senescence and how a small molecule may be useful in affecting this process. They published their findings in Cell Reports. A crucial molecule AKG is a major part of multiple fundamental metabolic processes, including the Krebs cycle that mitochondria use to generate energy, and...

In Aging Cell, researchers have published their findings that mice exposed to influenza experience long-term consequences that can be partially ameliorated with senolytics. Post-viral syndromes Long before the spread of the SARS-CoV-2 virus that causes COVID-19, it had been well-established that viral lung diseases such as influenza lead to lasting damage [1, 2]. Increased risks...