Tag: Cancer

Scientists have discovered that cancer cells recruit fibroblasts to support tumor growth by transferring mitochondria into them. Blocking this process might be a new way to fight the deadly disease [1]. It goes both ways Cancer doesn’t act alone. Its success often hinges on recruiting neighboring cells into cooperation with cancer cells. Sometimes, those neighboring...

In Aging Cell, researchers have reported that chromatin demethylation allows SASP compounds to be more easily expressed. Chromatin and gene expression Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical...

Scientists have demonstrated that injecting healthy mitochondria either systematically or directly into the tumor microenvironment boosts the efficiency of a standard anti-cancer therapy [1]. Mitochondria’s dual role in lung cancer While not the most prevalent type of cancer, lung cancer causes more deaths than any other. Non-small cell lung cancer (NSCLC) accounts for 85% of...

Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood factory Hematopoietic stem cells (HSCs) work hard for our entire lives, producing vast numbers of various blood cells. As we age, this process, like many...

Scientists have found that only about 1% of presented tumor antigens come from oncogenic mutations. The remaining 99%, previously overlooked, may offer better treatment targets [1]. Going after mutations Cancer arises from a series of mutations that drive abnormal cellular behaviors, such as runaway proliferation. Cancerous cells also normally present abnormal peptides on their surfaces...

Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many aging-associated molecular features as well as physical and cognitive performance, and it has a beneficial impact on cancer treatment in mice and cells [1]. Drugs for old cells Senotherapeutics are therapeutic agents that...