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Tag: Telomerase

Telomeres
In Nature Cell Biology, a team of researchers has presented a current review of telomeres and how they relate to aging, reflecting modern research into a decades-old topic. Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of...
Neurons
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes' bodyguards Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of repetitions of a single sequence:...
Heart Attack
Research published in Circulation has shown that mitochondrial, but not nuclear, telomerase reverse transcriptase (TERT) protects against damage caused by heart attacks in a murine model. A non-canonical role While TERT's name comes from its main function, the protection of telomere length in the cellular nucleus, the researchers make it clear that TERT has other...
Fibrotic liver
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts, cells that are a part of organ fibrosis. It also documents the link between telomere attrition and cellular senescence, two of the hallmarks of aging....
CGI of kidneys
A team of researchers led by Dr. Maria Blasco of the Spanish National Cancer Research Center has shown that shorter telomeres make mice more susceptible to kidney fibrosis [1]. The new study not only clearly demonstrates this link but also provides mouse models which can be used to study – and perhaps eventually address –...
Telomeres
An international collective of scientists has discovered a new cellular process: telomere transfer from antigen-presenting cells to T cells that boosts the latter's lifespan and proliferative potential [1]. Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of...