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Tag: Telomerase

CGI of kidneys
March 25, 2021
A team of researchers led by Dr. Maria Blasco of the Spanish National Cancer Research Center has shown that shorter telomeres make mice more susceptible to kidney fibrosis [1]. The new study not only clearly demonstrates this link but also provides mouse models which can be used to study – and perhaps eventually address –...
Telomeres
October 20, 2020
An international collective of scientists has discovered a new cellular process: telomere transfer from antigen-presenting cells to T cells that boosts the latter's lifespan and proliferative potential [1]. Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of repetitions of a...
August 18, 2020
The Journal Club returns August 25th at 13:00 EDT live on our Facebook page where Dr. Oliver Medvedik will be taking a look at the new study by Dr. Maria Blasco from the CNIO, which shows that telomerase therapy can address fibrosis in normally aged mice and not just mouse models of the disease. Short/dysfunctional...
X-ray of fibrosis
August 12, 2020
Back in January 2018, we reported that, for the first time, researchers had reversed lung fibrosis in mice using a single gene therapy. Today, we want to spotlight a new study that builds on the positive results of the 2018 research, taking us another step closer to telomerase gene therapy in humans to reverse pulmonary...
Telomere shortening
April 27, 2020
Researchers have demonstrated that it is possible to restore telomerase activity in stem cells affected by telomere biology diseases, which prevent them from producing telomerase and repairing their telomeres. Telomeres and telomerase Each chromosome that stores our genetic information has a protective cap at each end known as a telomere, a specific DNA sequence that...
Colombia
November 26, 2019
Recently, Libella Gene Therapeutics has announced that it will be running a patient-paid trial in Colombia with an eye-watering $1 million USD price tag on enrollment. Patient-paid trial likely to cause backlash The topic of patient-paid trials often stirs up considerable debate among the research community, regulatory authorities, and the general public, with many people...