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The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More
In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The
A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated
For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let’s see what’s been done last month to rejuvenate animals and people. Team and
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to
Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of
Rubedo Life Sciences, Inc. (Rubedo), an AI-driven, clinical-stage biotech focused on discovering and rapidly developing selective cellular rejuvenation medicines targeting aging cells, today announced preliminary results from a
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. The
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in
A new study identified two polyunsaturated fatty acids, α-eleostearic acid (α-ESA) and α-ESA methyl ester (α-ESA-me), that showed senolytic activity in cell cultures and a mouse model [1].
BioAge Labs, Inc. (“BioAge”, “the Company”), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging, today provided financial
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher
The Buck Institute for Research on Aging today announced the launch of Healthspan Horizons, a new initiative designed to address one of the most urgent challenges in modern
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