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A new study has found that increased production of serotonin by neurons in a particular brain region inhibits dopamine production and willingness to move, causing loss of activity. Killing serotonin-producing
Researchers have found that HDAC7 bridges together GSK3β and hyperphosphorylated tau protein (hTau) in neurons, which may spur Alzheimer’s disease. Getting rid of HDAC7 in hTau model mice ameliorated their
A recent study showed that a treatment with the short peptide elamipretide reversed multiple signs of age-related decline in oocyte quality in mice and in human oocytes in vitro [1].
A new study shows healthspan and lifespan increases in male mice following late-life treatment with vanadyl sulfate, a food-derived molecule marketed as an over-the-counter supplement [1]. Searching for vulnerabilities In
After a review of substantial literature, scientists publishing in Aging Cell have concluded that poor sleep quality and inflammaging worsen each other in a vicious cycle, reducing quality of life
In a clinical trial, the supplement NOVOS Core was associated with significant improvements in artery function and systolic blood pressure. It is unknown which particular ingredients are responsible for the
This month has been marked by progress in both the regulatory and investment sides of rejuvenation biotechnology. For years, the field has faced two major challenges: scientific advances outpacing the
A new study found that shrinking reserves of naive T cells weaken tumor recognition in male mice by middle age more than in females. Restoring thymic activity improved protection [1].
As the weather cools down, the race for functional interventions heats up, and members of our field have been looking for ways to push through bottlenecks both regulatory and scientific.
In a new study, late-life treatment with a three-element senolytic vaccine led to lower senescence markers and a 12% increase in median lifespan in female B6 mice. However, short-lived controls
In Aging Cell, researchers have described how increasing fibroblast growth factor 13 (FGF13) in astrocytes reduces aging throughout the bodies of mice. A factor from a well-known family FGFs are
A recent study identified SRSF1, an RNA-processing and splicing factor, as a molecule with geroprotective potential. Inducing SRSF1 expression rejuvenated human cells in vitro, extended lifespan, and significantly reduced frailty
One of the oldest and biggest longevity conferences moved this year across the Atlantic, from Copenhagen to Boston. The new location brought ARDD close to several important longevity hubs and
Life Biosciences (“Life Bio”), a biotechnology company pioneering cellular rejuvenation medicines to reverse diseases of aging, announced interim data from its Phase 1 clinical trial of ER-100 in three participants
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Researchers are developing biomedical repair therapies to address multiple age-related diseases at once, yet they are forced to put them through regulatory pathways built for single-disease drugs. The result is