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A perspective published in Aging and Disease has recommended the use of underground laboratory space in order to remove the effects of surface radiation on biological clocks. A question of
Scientists have linked disrupted Ca²⁺ homeostasis to aging in both progeroid and naturally aging mice. Rescuing it with a well-known antidepressant significantly increased the animals’ median and maximum lifespan [1].
Researchers have elucidated some of the links between the age-related loss of muscle (sarcopenia) and the age-related loss of bone (osteoporosis). Related in multiple ways Substantial previous research has described
Restricting food access to an 8-hour window increased median lifespan in male mice by 12%. However, that might be due to voluntary caloric restriction induced by the regimen [1]. You
Doing something about aging seems to require action at the most basic genomic level. Here’s what’s been done there and in other areas in June. Interviews The Thalion Initiative: A
A new study suggests a way to predict whether existing drugs can extend human lifespan. This method uses a network approach that detects longevity signals in protein interactions [1]. Slowing
Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs) do not themselves produce
A new study has used aging trajectories of various cell types to predict diseases such as Alzheimer’s and lung cancer [1]. This expands on previous research into organ-specific aging. Age
Researchers have found that sustained expression of excess hypoxia-inducible factor (HIF)-1α leads to unwanted formation of blood vessels (angiogenesis) that destroys cartilage and causes osteoarthritis. A necessary but destructive factor
NeuroAge Therapeutics announced Younger 2027, a six-month biological aging contest in which competitors are measured on a clinical-grade aging panel and retested six months later. Baseline testing kits begin shipping
A recent study suggests that hyperglycosylation in brain tissue can be a hallmark of Alzheimer’s disease [1]. Lesser-known Alzheimer’s molecular features Pathological deposits of amyloid-β plaques and tau tangles in
A new study links accelerated aging to early-onset solid cancers, while showing that this gap is becoming wider with each new generation [1]. Why do more young people get cancer?
Researchers have found that bound pieces of RNA and DNA in the cytoplasm of senescent cells encourage these cells to secrete inflammatory factors. When transcription gets sticky As part of
Scientists have targeted the thin fat layer around blood vessels with a transcription inhibitor, reducing symptoms of cardiometabolic disease [1]. When vessels can’t “just relax” Cardiometabolic disease (CMD) – characterized,