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A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and
In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence
Staying informed about health and longevity interventions can be tedious and time-consuming. Often it involves manually decoding a supplement label with numerous compounds, reading a blog post about
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made
A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of
Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own
Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – initially inspired high hopes. Several years
A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics The authors begin
The cost of the broken sickcare system Modern medicine is effectively based on a reactive management approach. It typically waits for an acute organ failure, such as a
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear,
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here’s
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and
A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results.
Montana’s first experimental treatment review board has brought three longevity heavyweights into the state’s effort to expand access to experimental therapies. How much regulation is too much? Many
In Aging Cell, researchers have published an explanation of how neutrophil extracellular traps (NETs) worsen UVB damage and how inhibiting them alleviated this damage in a mouse model.