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Scientists have targeted the thin fat layer around blood vessels with a transcription inhibitor, reducing symptoms of cardiometabolic disease [1]. When vessels can’t “just relax” Cardiometabolic disease (CMD) – characterized,
In Aging Cell, researchers have described the way that antioxidants work against senescence in muscle cells by altering mTOR signaling. Senescent cells don’t sense nutrients properly Oxidative stress and mTOR
In a new study, muscle-targeted viral-vector-based delivery of the protein FGF21 significantly increased median lifespan in male mice and improved many healthspan markers [1]. Control your energy Metabolic dysregulation is
A team of reviewers has taken a look at the relationship between cancer, cellular senescence, and vascular overgrowth and published this information in Aging Cell. Different gut cancers form through
Scientists have “faked” sleep in mice by artificially creating the on/off neuronal firing pattern similar to that seen in non-REM sleep. This produced sleep-like effects, including improved learning memory [1].
In a recent paper, researchers have proposed that the immune system and immune surveillance play a central role in maintaining microbial composition throughout life by suppressing microbial proliferation and that
In Aging Cell, researchers have described how a strain of Lactobacillus gut bacteria sends chemical signals that enter the bloodstream and decrease fibrosis in the lungs. The gut-lung axis The
As longevity moves from laboratory promise toward clinical validation, China is emerging as one of the largest demand bases shaping the field’s next phase. On September 12–13, 2026, the 7th
Researchers have explained how a protein found in both yeast and humans facilitates the destruction of the core protein responsible for Parkinson’s disease. An aggregate that impairs clearance The loss
According to a new study, a special protein disposal system, currently found only in neurons, is linked to central hallmarks of Alzheimer’s disease [1]. The membranal proteasome Alzheimer’s disease is
Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing miR-330, a key regulator in cartilage and bone cells. Backbreaking labor is exactly that
The Forever Healthy Foundation today publicly launched evipedia.ai, an open online encyclopedia of in-depth evidence reviews covering more than 500 health and longevity interventions, including first-generation rejuvenation therapies, supplements, botanicals,
The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires understanding it first. With
Approaches that modify the processes of aging at their roots have gone well beyond basic research and into therapies intended for the clinic within the next few years. Here’s how
The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age and entering the mainstream.