March 13, 2024
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...
October 29, 2023
According to a review published in Food Science and Human Wellness, resveratrol has a positive impact on mitochondrial dysfunction, one of the hallmarks of aging. A hallmark with downstream consequences Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that...
October 27, 2022
A recent study published in Molecules has tested multiple thiazole-based derivatives that appear to activate the sirtuin SIRT1 more than resveratrol [1]. Sirtuins Resveratrol, commonly found in grape skins and red wine, generated some of the initial interest in sirtuin activators after initial studies showing many therapeutic benefits, such as cancer prevention [2]. Combined with...
July 12, 2022
Researchers have shown that resveratrol reverses several features of ovarian aging in mice while activating most sirtuins and boosting mitochondrial health [1]. Ovaries age first In many mammals, including humans, ovarian aging is premature compared to other systems. The reasons for this accelerated loss of function are not entirely clear, but they are known to...
March 07, 2022
On this episode of Lifespan News, Ryan O'Shea revisits the ongoing controversy involving resveratrol and the widely known longevity enthusiast David Sinclair. Script In a recent episode of Lifespan News, we discussed a controversy surrounding resveratrol, and today, we’ll update you on the reaction to that video and how we’ll approach this going forward. Resveratrol...
February 25, 2022
Scientists have shown that resveratrol rescues erectile function in aged rats, most probably by activating SIRT1, and that it can work in synergy with the existing erectile dysfunction treatment tadalafil [1]. A molecule of discord Resveratrol, a plant-derived chemical of the polyphenol family, was once considered one of the most promising anti-aging molecules. David Sinclair’s...