February 19, 2024
In Aging, a team of researchers has outlined a possible relationship between low grip strength and compounds in the gut microbiome. The gut-muscle axis As these researchers note, previous work has described many of the various ways in which metabolism is related to age-related muscle dysfunction, including inflammation, oxidative stress, accumulation of advanced glycation end-products...
September 28, 2023
In a recent article in Nature, researchers have restored cardiac regeneration to adult mice by disabling fatty acid oxidation, discovering a potential pathway for human treatments. A question of metabolism As heart muscle cells (myocytes) mature, they make a metabolic switch from glycolysis to the oxidation of fatty acids. Previous research has found that this...
May 17, 2023
Publishing in Aging, a team of Chilean researchers has described a relationship between gene shifts in the brain and neurons not getting the energy they need. Greedy glia BrainThe brain is perhaps the most important organ in the body. While many organs are critical to our survival, the brain contains the self. It is responsible...
February 03, 2023
Scientists have shown that a popular senolytic combination of dasatinib and quercetin improves glucose tolerance and fasting blood glucose levels in aged mice [1]. The question of metabolism Cellular senescence is one of the hallmarks of aging, and senolytics, drugs that clear away senescent cells, have been shown to ameliorate some aging phenotypes. However, not...
October 21, 2022
Scientists have shown that both high-intensity interval training (HIIT) and time-restricted eating improve metabolism in healthy overweight women, with their combination providing the biggest effect [1]. Which one is better? Good dietary habits and physical activity are currently our best options for living longer and healthier lives. In recent years, two interventions have been gaining...
August 02, 2022
Researchers publishing in Journal of Biomedical Science have concluded that hesperetin, a compound found in various herbs, improves longevity in mice by promoting the expression of the pro-longevity gene Cisd2. Mitochondria and Cisd2 This paper begins with an explanation of mitochondrial dysfunction, one of the hallmarks of aging, and the function of Cisd2. Previous research...