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Tag: Inflammaging

Knee joint
Researchers have described how specialized nanoparticles, which deliver rapamycin and the antioxidant astaxanthin, restore macrophage balance and reduce inflammation in a mouse model of osteoarthritis. A matter of polarization Inflammation is a critical part of arthritis. Previous studies have found that inflammation of the membranes in joints (synovitis) strongly contributes to osteoarthritis [1]; in fact,...
Young to old
Researchers have described an intermediary state between senescent and young cells, the inflammatory problems caused by these cells, and how young cells secrete a protein that may alleviate these problems. What happens before senescence? Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support...
Genetic damage
Publishing in Ageing Research Reviews, a team of researchers including Vera Gorbunova has described how a class of drugs originally used to treat HIV might be used to affect some of the hallmarks of aging. Inhibiting DNA changes DNA transcription, which transfers DNA code into the RNA that cells use to make proteins, can also...
Advanced Clock
In a paper published in Geroscience, researchers have developed a metric of systemic inflammation and used it to estimate mortality, finding that it performs better than epigenetic clocks. Evaluating a danger What is Inflammaging? Chronic Inflammation and AgingOne of the aging processes consists of a chronic, smoldering background of inflammation that researchers call “inflammaging”.Read More...
Brain Inflammation
Scientists publishing in Nature have explained a key pathway that leads to immune dysfunction and neurodegeneration in aging. Feeling the STING Throughout this paper, the researchers cite other papers demonstrating a cause-and-effect relationship between initial damage and long-term effects. Perturbed mitochondria release their mitochondrial DNA (mtDNA) into the internal liquid (cytosol) of microglia, the helper...
Calcium
Scientists have reported in Nature Aging that impaired mitochondrial uptake of calcium ions leads to changes in inflammatory responses that resemble what happens in aging [1]. Inflammation and aging Inflammation is an essential, evolutionarily conserved process and a fundamental part of the immune response, providing immediate defense against infections by pathogens such as bacteria, viruses,...