June 28, 2023
In a new study published in Aging Cell [1], researchers report that transient activation of the Yamanaka factor Oct4 allowed partial reprogramming of cells, which led to rejuvenation in these cells and in a mouse model of premature aging. Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4,...
May 26, 2023
Scientists have found that continuous oxygen restriction drastically extends the lifespan of progeroid mice, but the effect's mechanism remains a mystery [1]. Can less oxygen be better? Hypoxia is a condition in which an organism or an organ in the body does not receive enough oxygen. However, how much is enough, and whether we are...
December 09, 2021
A new case report published in the International Journal of Molecular Sciences highlights cardiovascular improvements in a patient with Hutchinson-Gilford progeria treated with umbilical cord blood. Hutchinson-Gilford Progeria SyndromeHutchinson-Gilford progeria syndrome, also known simply as progeria, is a disease characterized by premature aging. Patients with progeria develop many of the same conditions that normally occur...
January 07, 2021
A gene editing technique published in Nature has proven to be effective in a mouse model of Hutchinson–Gilford progeria syndrome (HGPS). A single error causes tremendous damage HGPS is a well-known disease that causes visible aging and early death in children. In progeria, the lamina that protects the genetic information in the nucleus is greatly...
June 19, 2020
LMNA, a gene coding for lamins, whose mutations cause many developmental diseases, is linked to Hutchinson-Gilford Progeria (HGP) [1]. HGP is a disease that causes premature aging and is currently affecting around 390 children. Their average life expectancy is around 13 years, but some affected individuals can live to 20 years. Nuclear lamins are fibrous...
December 04, 2019
If humans ever reach an average lifespan of well over 100 years, what is going to happen? Are we going to be bored with such long lives? "Well," says Prof. Brian Kennedy of the National University of Singapore, "If you ask me: 'Do I want to have cancer at 75? Do I want have Alzheimer’s...