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Tag: OSKM

Mouse DNA
A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice. A new handle on old problems The researchers begin this study with a discussion of the known problems of aging research. They bring up the...
Playing mice 800x450
  Scientists have shown that continuous low-dose induction of reprogramming factors and a single early life reprogramming treatment both significantly increase lifespan and healthspan in progeroid mice while altering their epigenetic landscape [1]. In vivo reprogramming Cellular reprogramming is the process of treating cells with compounds that nudge them towards a pluripotent state. The classical...
Powerful mixture
A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This paper begins with a discussion of the four well-known Yamanaka reprogramming factors (OSKM) that cause cells to revert to a previous epigenetic state, citing previous...
Fluorescent cells
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Yamanaka Factors and Partial Cellular ReprogrammingDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed...
Two Directions Infinity
In a preprint published in bioRxiv, a team of Singaporean researchers, including Jan Gruber, has found that a combination of stem cell rejuvenation and senescent cell removal is synergistically more effective than either alone. Different but related aspects of aging Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent...
Genetic research
Scientists have shown that a single cycle of partial cellular reprogramming leads to various changes in the tissues, but about half of them gradually disappear after the treatment [1]. Permanent or transient? It has been known since 2006 that somatic cells can be reverted to a pluripotent stem cell-like state by overexpressing certain regulatory genes....