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Tag: OSKM

Epigenetic wrapping
April 12, 2021
A new technique allows researchers to turn epigenetic methylation off and back on again, thus allowing the silencing and unsilencing of certain genes. A CRISPR breakthrough CRISPR/Cas9 is a well-known technology for editing the genome, but its potential for epigenetic editing had never been previously explored. With a directed CRISPR memory writer able to methylate...
Press the reset button
March 08, 2021
Today, we chronicle the progress of partial cellular reprogramming and discuss how this powerful treatment may be able to reprogram cells back into a youthful state, at least partially reversing epigenetic alterations, one of the proposed reasons we age. For those of you new to the subject of epigenetic alterations you can learn more by...
LifeXtenShow on cellular rejuvenation
February 15, 2021
In this episode of X10, Nicola explains a way to epigenetically reset cells using the OSKM Yamanaka factors, putting them back into a pluripotent stem cell state. These factors have also been experimentally shown to restore cells to youth in other ways, and it is also possible to carefully use these factors to make cells...
Someone physically turns back a clock
January 21, 2021
Researchers from the Reik lab at the Babraham Institute have used the four Yamanaka reprogramming factors (OSKM) in order to epigenetically rejuvenate cells by 30 years, according to one epigenetic clock. Why we Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of...
Mouse eye
December 04, 2020
Researchers at the Sinclair Lab at Harvard Medical School have restored lost vision to old mice, and mice with damaged retinal nerves, using partial cellular reprogramming. The aged cells can be reset to become younger again using this approach and are better at repairing damaged tissue. The approach has huge potential in the treatment of...
Journal Club
November 05, 2020
The Journal Club with Dr. Oliver Medvedik returns on November 24th at noon EST and will be livestreamed on our Facebook page. The topic this month will be a new study in which researchers have again demonstrated that it is possible to reverse aspects of aging in the old cells of a living animal, not...