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Tag: OSKM

March 24, 2020
Researchers at Stanford University have demonstrated they can rejuvenate human cells, making them more like young cells again, by rewinding an epigenetic aging clock. Epigenetic alterations and aging One of the hallmarks of aging is epigenetic alterations, which are the alterations to gene expression that our cells experience with age. They harm the fundamental functions...
March 13, 2020
Today, we are going to take a look at the companies working on resetting cellular aging through a reprogramming approach that directly targets a core reason we age. Cellular reprogramming resets aging in cells As we age, our cells experience alterations to their epigenetic markers, and this, in turn, changes gene expression; this process is...
November 08, 2019
A recent open-access study published in Cell Stem Cell has shown that excluding Oct4 from the OSKM cocktail reduces epigenetic aberrations and off-target gene activation. Induced pluripotency and Yamanaka factors Pluripotent stem cells are cells that can become other cell types in the body; during natural development, they create differentiated stem cells and ultimately somatic...
August 16, 2019
A new study outlines multiple ways in which epiblast stem cells can be reprogrammed back into a fully pluripotent state, paving the way for a better understanding of epigenetics. The role of epigenetics Epigenetics are why our cells, which all have the same DNA, differ in function. A bone cell has the same genetics as...
August 06, 2019
Today, we want to draw attention to a new study that shows how partial cellular reprogramming was able to reverse cellular aging and address age- and injury-induced blindness in mice. Epigenetic alterations One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are...
April 05, 2019
At the Undoing Aging 2019 conference, we had the opportunity to interview Yuri Deigin, the CEO of Youthereum Genetics. His company is developing therapies that focus on OSKM, the Yamanaka factors known for turning cells back into a pluripotent state. By partially reprogramming cells using a single component of OSKM, Oct4, the company hopes to...