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Tag: OSKM

November 05, 2020
The Journal Club with Dr. Oliver Medvedik returns on November 24th at noon EST and will be livestreamed on our Facebook page. The topic this month will be a new study in which researchers have again demonstrated that it is possible to reverse aspects of aging in the old cells of a living animal, not...
October 26, 2020
Today, we want to highlight another study that takes us a step closer to getting partial cellular reprogramming to the clinic. Partial Cellular ReprogrammingDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed that cellular identity and aging could...
October 21, 2020
The latest research published in the Journal of Tissue Engineering and Regenerative Medicine has reprogrammed pig fibroblast cells into neural progenitor cells.
March 24, 2020
Researchers at Stanford University have demonstrated they can rejuvenate human cells, making them more like young cells again, by rewinding an epigenetic aging clock. Epigenetic alterations and aging One of the hallmarks of aging is epigenetic alterations, which are the alterations to gene expression that our cells experience with age. They harm the fundamental functions...
March 13, 2020
Today, we are going to take a look at the companies working on resetting cellular aging through a reprogramming approach that directly targets a core reason we age. Cellular reprogramming resets aging in cells As we age, our cells experience alterations to their epigenetic markers, and this, in turn, changes gene expression; this process is...
March 09, 2020
Researchers from AgeX Therapeutics and other organizations have proved the feasibility of reprogramming banked cells derived from a supercentenarian. Their discovery portends exciting new possibilities for aging research. What is cellular reprogramming? Cellular reprogramming is the process of reverting mature, specialized cells into induced pluripotent stem cells (iPSCs), which can develop into any cell type...