Help us: Donate
Follow us on:
×

Menu

Back

Tag: OSKM

LifeXtenShow on cellular rejuvenation
February 15, 2021
In this episode of X10, Nicola explains a way to epigenetically reset cells using the OSKM Yamanaka factors, putting them back into a pluripotent stem cell state. These factors have also been experimentally shown to restore cells to youth in other ways, and it is also possible to carefully use these factors to make cells...
Someone physically turns back a clock
January 21, 2021
Researchers from the Reik lab at the Babraham Institute have used the four Yamanaka reprogramming factors (OSKM) in order to epigenetically rejuvenate cells by 30 years, according to one epigenetic clock. Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and other...
December 04, 2020
Researchers at the Sinclair Lab at Harvard Medical School have restored lost vision to old mice, and mice with damaged retinal nerves, using partial cellular reprogramming. The aged cells can be reset to become younger again using this approach and are better at repairing damaged tissue. The approach has huge potential in the treatment of...
Journal Club
November 05, 2020
The Journal Club with Dr. Oliver Medvedik returns on November 24th at noon EST and will be livestreamed on our Facebook page. The topic this month will be a new study in which researchers have again demonstrated that it is possible to reverse aspects of aging in the old cells of a living animal, not...
October 26, 2020
Today, we want to highlight another study that takes us a step closer to getting partial cellular reprogramming to the clinic. Partial Cellular ReprogrammingDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed that cellular identity and aging could...
Piglet
October 21, 2020
The latest research published in the Journal of Tissue Engineering and Regenerative Medicine has reprogrammed pig fibroblast cells into neural progenitor cells.