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Tag: Immunosenescence

Happy mouse
By activating toll-like receptor 5, an important element of the innate immune system, scientists have increased lifespan and improved multiple health measurements in old mice, despite having started the treatment late in life [1]. TLRs and aging The immune system gets dysregulated with age, driving multiple age-related conditions [2]. It is manifested in higher tumor...
Cascading Waterfall
In a study recently published in Biochemistry and Biophysics Reports, researchers have shown that growing natural killer (NK) cells and re-introducing them back into the human bloodstream reduces senescence markers in a wide variety of immune cells. Peripheral blood mononuclear cells This research focuses on peripheral blood mononuclear cells (PBMCs), a category that includes T...
A new review takes a look at the association between the decline of the immune system and the development and course of age-related diseases. Our immune system is the ultimate defense against invading pathogens and unwanted waste, and its efficient operation is critical to the healthy function of every tissue in the body. We have...
Image of scissors cutting DNA to represent gene editing with CRISPR
The body can be home to many latent viruses, which can lie dormant for years only to be activated much later under certain conditions. Now, researchers may have the solution to one such persistent virus: herpes simplex virus 1, which is commonly known as oral herpes. Latent viruses put strain on the immune system A...
Frailty and the decline of the immune system are two typical features of aging, but new research shows that both can be halted and even somewhat reversed using a novel cell-based therapy. Frailty and immunosenescence Frailty is something that frequently affects older people, and it ultimately results in the loss of independence and quality of...
Researchers from the Monash Biomedicine Discovery Institute have made progress in the quest to rejuvenate the aging immune system by identifying the factors responsible for the age-related decline of the thymus.  The thymus shrinks as we age The thymus is one of the most important organs in the body, and it is where thymocytes produced...