July 14, 2022
An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. Why we Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of age-related diseases, including Alzheimer's...
September 18, 2019
Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells senescent. Senescence is primarily caused by telomere shortening and DNA damage, and senescent cells are known to contribute to multiple diseases, such as Alzheimer's, Parkinson's,...