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Tag: CAR-T

White blood cells
Scientists have found that giving CAR T cells a particular oncogenic mutation greatly improves their efficiency against blood and solid cancers [1]. Less than cancer One reason why cancer is so dangerous is that oncogenic mutations boost cancer cells’ survivability, just like a genetically modified monster in a sci-fi movie. When T cells go haywire...
CAR T Cells
Scientists have created CAR T cells that target senescent cells. This approach alleviated metabolic dysfunction in mice [1]. Immunotherapy is not just for cancer Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit...
Shielded cells
Scientists have created improved CAR T cells that also express the cytokine IL-10. The new cells proved highly effective in mice and in a pilot human trial [1]. The promise and the limitations Chimeric antigen receptor (CAR) T cells are among the most promising treatments in oncology. To create them, immune T cells are genetically...
Cell manufacturing
A pair of researchers from Stanford University have published a detailed review of the current state of CAR T immune cell therapies in Nature. A new state of the art in fighting cancer Chimeric antigen receptor (CAR) is a technology that allows researchers to alter T cells to attack specifically chosen targets. As of this...
Multiple myeloma
The results of a Phase 1 clinical trial of allogeneic CAR T cell therapy against multiple myeloma have been published today in Nature Medicine, and they appear to be promising. B cells, engineered T cells, and lymphodepletion Multiple myeloma is a cancer of the plasma B cells, which are formed in the blood marrow and...
Destroy cancer
A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on signals This highly in-depth paper begins with a discussion of signaling in the response of chimeric antigen receptor (CAR) T cells, as good signals are...