Today, we are pleased to announce, at long last, that we will be launching a new project on the research fundraising platform Lifespan.io. The platform helps researchers to crowdfund projects focused on healthy longevity, and this new project is no exception.
The David Sinclair Lab launches a new project on September 18th over at Lifespan.io and focuses on the study of nicotinamide mononucleotide (NMN) and its effects on health and lifespan in normally aged mice.
NMN is a precursor molecule of nicotinamide adenine dinucleotide (NAD), a molecule that regulates a myriad of cellular functions and facilitates DNA repair, nutrient sensing and metabolism, tissue growth, energy production, and more. To learn more about NAD, NMN, and how NAD affects aging, check out our NAD World articles.
The first long-term lifespan study in mice involving supplementation with NMN, a precursor of NAD+ metabolism, which has been shown to reduce aging markers and increase sirtuin activity. We propose to conduct a longevity study using NMN in the drinking water of wild-type mice. We also plan to test NMN with a novel model of accelerated aging mice known as ICE mice (Induced Changes In Epigenome).
The team will be introducing NMN to the drinking water of already aged mice that have grown old normally; this is very important, as this is not engineered aging, as seen in progeric mice, and represents true aging with all its nuances. That also means that any resulting improvement in healthspan or lifespan are less likely to be the result of how a mouse was engineered and more likely the result of the NMN. The study using regularly aging mice will be a world first and should yield important information that could help support the progress of the human clinical trials currently underway.
Another important part of the experiment will be the use of special ICE mice. These mice have accelerated aging driven by induced changes in the epigenome. Unlike older strains of progeric mice, these mice have been designed to more closely emulate human aging, and the researchers will use them to help answer questions about behavioral and physiological changes during the experiment. The ICE mice will not be part of the lifespan study but they could provide the researchers with valuable information.
We are excited about this project, as it has the potential to tell us a lot about NAD+ biology and its relationship to aging, and this research could help to fuel progress towards human use in the fight against age-related diseases. Check back with us over at Lifespan.io on September 18th, and watch this space for interviews and more news about this project in the coming weeks.