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Robert Shmookler Reis Joins the LEAF Advisory Board


We are very pleased to announce that Dr. Robert Shmookler Reis has joined the LEAF scientific advisory board. He studied at Harvard University (B.A.) and Sussex University (D.Phil.). He joined the University of Arkansas for Medical Sciences in 1980, where he holds the Udupa Chair of Gerontologic Research; he also serves as Affiliate Professor of Pathology at the Univ. of Washington in Seattle WA.

Dr. Robert Shmookler Reis is an expert in genetics whose work focuses on the molecular genetics of longevity and age-associated diseases and his team holds the world record for life extension in C. elegans (roundworms) making them live ten times their normal lifespan.

Protein aggregation in aging

His research team has recently been studying aggregates and their accumulation in relation to aging and the presence of certain proteins in neurodegenerative diseases. They also looked at aggregation in other tissues to see if it was a general feature of aging and it is, which aligns with the loss of proteostasis as described in the Hallmarks of aging. His team showed that a number of aggregates contribute to loss of muscle mass, he explains more in this short video about the recent study.

We look forward to seeing what the team discovers next and if they can develop therapies to prevent the formation of aggregates.

Dr. Robert Shmookler Reis is an advocate for basic research and believes that in order for us create effective strategies against aging we must invest not only in development but also in the basic science that improves our understanding of aging.


We are delighted to welcome Dr. Robert Shmookler Reis to our scientific advisory board and look forward to benefiting from his wealth of knowledge and expertise in genetics.


[1] Ayyadevara, S., Balasubramaniam, M., Suri, P., Mackintosh, S. G., Tackett, A. J., Sullivan, D. H., … & Dennis, R. A. (2016). Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans. Aging (Albany NY), 8(12), 3486.

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