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MMTP September 2018


Today, we have an update from the MMTP Project team. The project was launched on back in 2016 with the aim of testing senolytics and their effect on lifespan, it was successfully funded and raised 15% over its initial goal.

Hi everyone, it has been a long time so we thought it was time for a small update. We wanted to let you all know that the mouse study has been significantly delayed due to the strict regulations in Germany concerning animal welfare. In Germany, there is a lot of paperwork to complete and high standards to reach before permission is granted for an animal study. Dr. Stolzing continues to work with government representatives and the animal testing factility in Leipzig to move things forward, though it is likely additional ethics reviews will be required by the authorities.

Meanwhile we are going to conduct in vitro testing using six different senolytic or potentially senolytic drugs in various combinations, as multiple previous tests on senolytics done by other groups suggest that each one favors a different cell type. There are no previous studies exploring the potential of combinations of senolytics, with the exception of the work done with dasatinib and quercetin.

Many of the compounds that we are testing are known to target different types of senescent cells; therefore, a combination could potentially improve their efficiency, as Dr. Peter de Keizer recently suggested when he discussed senolytic “cocktails”.

Thank you once again to all our generous supporters who helped make the project a reality, and we hope that it leads to some interesting results once the research team publishes its findings.


The MMTP Team

About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 500 articles on the topic as well as attending various medical industry conferences. In 2019 he was listed in the top 100 journalists covering biomedicine and longevity research in the industry report – Top-100 Journalists covering advanced biomedicine and longevity created by the Aging Analytics Agency. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, and, Keep me Prime, and New Economy Magazine. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project. In 2015 he led the Major Mouse Testing Program (MMTP) for the International Longevity Alliance and in 2016 helped the team of the SENS Research Foundation to reach their goal for the OncoSENS campaign for cancer research.
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