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Microbiota from Young Mice Improves the Brains of Old Mice

Journal Club September 28th at 12:00 ET

Journal ClubJournal Club

After taking a break due to the Ending Age-Related Diseases Conference, the Journal Club is back.

For September, Dr. Oliver Medvedik will be taking a look at a recent paper focused on the gut microbiome and how it influences brain health.


The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3–4 months) or old (19–20 months) donor mice into aged recipient mice (19–20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.

The show will be aired on Facebook at 12:00 Eastern on September 28th but Lifespan Heroes can join the call live for the discussion. The zoom call details can be found below and we look forward to seeing you again soon.

Topic: Journal Club September
Time: Sep 28, 2021 12:00 PM Eastern Time (US and Canada)

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Boehme, M., Guzzetta, K. E., Bastiaanssen, T. F., van de Wouw, M., Moloney, G. M., Gual-Grau, A., … & Cryan, J. F. (2021). Microbiota from young mice counteracts selective age-associated behavioral deficitsNature Aging, 1-11.

CategoryHeroes Corner
About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
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