We are testing a combination of compounds that clear out dysfunctional cells in the body, called senolytics, to see if we can extend maximum lifespan and healthspan in mice. Please subscribe, share, and fund our Lifespan.io campaign today!
According to modern science, aging is the accumulation of damage that the body cannot completely eliminate, due to the imperfections of its protection and repair systems. The good news is that the processes that constitute aging are amenable to medical intervention. We can slow down or even reverse some aspects of aging by applying different therapies, preventing or blocking some of these processes.
One of these processes of aging is cellular senescence.
Senescent cells normally self destruct via a process called apoptosis, but unfortunately not all of them do. These “death resistant” senescent cells accumulate in the body with age and secrete toxic signals. This causes inflammation and damage to organs and tissues, increasing the risk of cancer and other diseases of old age. This is why these cells are often called “good citizens but bad neighbors”. They remain partially functional, but their presence does more harm than good.
A new class of drugs, known as senolytics, have recently demonstrated the ability to remove senescent cells, thus improving health. However, the potential of senolytics to increase health and lifespan beyond current maximums remains unknown. This is what we at Major Mouse Testing Program want to investigate – with your help!