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LifeXtenShow – Cellular Rejuvenation

The Yamanaka factors can turn somatic cells back into stem cells.
LifeXtenShow on cellular rejuvenationLifeXtenShow on cellular rejuvenation



In this episode of X10, Nicola explains a way to epigenetically reset cells using the OSKM Yamanaka factors, putting them back into a pluripotent stem cell state. These factors have also been experimentally shown to restore cells to youth in other ways, and it is also possible to carefully use these factors to make cells epigenetically young again without having them lose their cellular identities.

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Sources

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

DNA methylation age of human tissues and cell types

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

Recapitulation of premature aging with iPSCs from Hutchinson Gilford Progeria Syndrome

In vivo amelioration of age-associated hallmarks by partial reprogramming

Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research

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