This week on Lifespan News, Brent Nally discusses education and life expectancy, the CNIO and telomeres, quantum dot nanomedicine, a health-related data project in the UK, and a connection between Alzheimer’s and sight loss.
Adult longevity, education, and racial identity
A CNIO team discovers how telomere involvement in tumor generation is regulated
Quantum Dot Nanomedicine for Longevity Drugs
Major Health-Related Data Project Secures Funding in the UK
New study links protein causing Alzheimer’s disease with common sight loss
Is there any correlation between longevity, a college education and racial identity? Find out by sticking around for this story plus we’ll have other stories in this episode of Lifespan News.
Welcome to Lifespan News on X10, your source for longevity science updates. I’m your host, Brent Nally. If you missed our last episode, then you can watch it by clicking the card above. We encourage you to check the description below for links to these stories.
Continuing with our first story, researchers in the United States have shown that there’s a longevity advantage of having a bachelor’s degree, and this advantage has increased in the US over the past three decades, while at the same time, the racial gap in life expectancy has decreased. Using data from the national vital statistical system to analyze mortality rates for 48.9 million adults, the researchers made a 1990 to 2018 time series of mortality rates and expected years lived from 25 to 75. Individuals with a BA made continuous progress between 1990 and 2018 and could expect to live 48.2 years between the ages of 25 years and 75 years by 2018. By contrast, those without a BA showed a decline after 2010 and could expect to live only 45.1 years between the ages of 25 years and 75 years by 2018. There was little increase in adult life expectancy for whites but substantial gains among blacks until 2012, narrowing the racial gap by 70%. The researchers state “currently, adult longevity is more strongly linked to a BA than to racial identity, in contrast to the situation in 1990.”
For our next story, a Spanish team discovers how telomere involvement in tumour generation is regulated. The Telomeres and Telomerase Group, led by Spanish National Cancer Research Center Director Maria Blasco, is making more progress in understanding the role of telomeres in cancer development. Telomeres are known to function as protective caps at the end of chromosomes, preventing the strands from fraying or accidentally fusing with each other. Telomeres also regulate cellular aging, in that when telomeres become too short as a consequence of cell division, cells stop dividing. This mechanism is thought to be one of the ways the body prevents tumor formation. The group was among the first to suggest that shelterins, which is a type of protein complex wrapped around telomeres to protect them, could be viable targets for cancer therapies. Indeed, the researchers had previously showed that eliminating a particular shelterin, TRF1, prevented the initiation and progression of deadly cancers such as lung cancer and glioblastoma in mice. Recently, the group found out how telomeres can be regulated from signals from outside the cells, and how these signals may induce abnormal cell proliferation. The researchers found a link between the aforementioned shelterin TRF1 and the AKT signaling pathway. By genetically modifying TRF1 to be unresponsive to AKT, the researchers observed that telomeres in the modified cells shortened and accumulated more damage, which made them unable to form tumors. The next step will be to generate genetically modified mice with telomeres that are invisible to AKT to see if this will make the mice more cancer-resistant, as the researchers expect.
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A new delivery method based on nanoparticles could improve the efficiency of NMN and metformin in the liver. Nanotechnology holds significant promise for medicine, offering the possibility of using nanomaterials to carry drugs or control their release. One challenge is that nanomedicines are taken up more by the liver than other tissues. So a research team at the university of sydney decided to take advantage of this to deliver medicines that target metabolic conditions in the liver. The researchers created quantum dots, or QDs, 7 nanometers in size as a drug delivery vehicle. These QDs accumulate in the liver and are then rapidly cleared from the body. The team attached metformin and nicotinamide mononucleotide, or NMN, to the QDs and added these to the drinking water of mice. The researchers showed that the use of QDs made metformin as effective as a dose 100 times stronger, and for NMN, the difference was about 1000-fold. The researchers also showed that QD-NMN was able to improve glucose tolerance and reduce fasting insulin and insulin resistance in 18 and 24-month old mice. NMN did not have the same effect, even at doses 100 times greater. It will be interesting to see if follow-up research is able to repeat these results, determine these mechanisms at play, and eventually translate the findings to humans.
Moving on, a major health-related data project secures funding in the United Kingdom. In the UK, the All-Party Parliamentary group, or APPG, for Longevity has secured funding for its Open Life Data Project, which aims to create a framework for effective and ethical collection of health-related data on a national level. The Open Life Data Framework, or OLDF, is described as “a collaborative ecosystem to stimulate social and business model innovation using ethical data models.” APPG co-founder, Tina Woods, highlighted the importance of including non-health data, such as “the data gathered by wearables and smartphone apps, but also shopping purchases, social media and banking transactions”. Tina cites the importance of cataloguing “the complex environmental exposures we are subjected to throughout our lives, including our diet, lifestyle factors, and social influences, and our body’s response to these challenges.” Wearables can be used to collect both health data and non-health data. A major issue is privacy concerns, which make people reluctant to share their data. To that end, one of the goals of the OLDF is to “build public trust in the use of data for individual and collective health and social care purposes”. The authors of the framework also address questions of inequality, noting that the COVID pandemic has underscored the vast differences in overall health and health outcomes among groups divided by race, gender, and income. According to the authors, gathering more data will help scientists, physicians, and governing bodies better understand and address those differences. Effective and safe ways of gathering, sharing, and using such data can revolutionize healthcare. The work of APPG for Longevity, and the OLDF in particular, provide an encouraging example of the governmental involvement needed to implement these changes. To find out more, check out our interview of Tina Woods and our review of Tina’s recent book in the description below.
For our final story, a new study links proteins associated with Alzheimer’s disease with a common loss of sight. New research has revealed a link between amyloid-beta, or AB, which is a protein associated with Alzheimer’s disease, or AD, and age-related macular degeneration, or AMD, which is one of the most common causes of vision loss with age. AB is known to accumulate not only in the brains of ad patients, but also in the retina of the eye as people get older. This is evident in donor eyes from patients who suffered from amd. In particular, a new study published in cells investigated the effect of AB exposure on retina cells of normal mouse eyes. According to their findings, the resulting pathology was strikingly similar to human AMD. According to the researchers, AB proteins collected in the lysosomes of retinal cells. The lysosomes’ job is to clear unwanted waste from the cell, but the lysosomes were unable to break down AB, so up to 85% of AB remained within these cells. This also meant that fewer lysosomes were available to perform other routine waste breakdown. The researchers hope that one of the next steps in their research might be the repurposing of Alzheimer’s drugs to break down amyloids in the retina.
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