Help us: Donate
Follow us on:



Lifespan News – CRISPR for Immune System Invisibility

The resulting stem cells could be used without the need for immunosuppressants.

LSN Crispr Immune InvisibilityLSN Crispr Immune Invisibility

On this episode of Lifespan News, we discuss using CRISPR-engineered stem cells that do not evoke an immune response.


A lot of people frequently ask me what I think about CRISPR-Cas9 and when I think it will be ready for widespread therapeutic use in humans. My answer is CRISPR is super exciting and promising biotech, but I don’t know when it will be ready for widespread therapeutic use in humans, but I hope soon!

Gene editing can make stem cells invisible to the immune system, making it possible to carry out cell therapy transplants without suppressing the patients’ immune response. Scientists in the US and Germany used immune engineering to develop universal cell products that could be used in all transplant patients. The idea is to create stem cells that evade the immune system; these hypoimmune stem cells are then used to generate cells of the desired type that can be transplanted into any patient without the need for immunosuppression, since the cells won’t elicit an immune response.

They used CRISPR-Cas9 to knock out two genes involved in the major histocompatibility complex, which is used for self/non-self discrimination. They also increased the expression of a protein that acts as a β€œdon’t eat me” signal to protect cells from macrophages. Together, these changes made the stem cells look less foreign and avoid clearance by macrophages.

The team then differentiated endothelial cells and cardiomyocytes from the engineered stem cells, and they used these to treat three different diseases in mice. Cell therapy treatments using the hypoimmune cells were effective in rescuing hindlimbs from vascular blockage, preventing lung damage in an engineered mouse model, and maintaining heart function following a myocardial infarction.

This is an exciting advancement for CRISPR, but I still don’t know when CRISPR is going to be ready for therapeutic use in humans. What’s your best guess? Let us know what you think in the comments.

Immunosuppression poses obvious risks to a patient, and generating custom cells for transplant therapy is often prohibitively expensive. The development of universal donor cells that can be used as therapeutics could bring the cost down significantly, making cellular therapeutics available to many more patients in a much safer way.

We would like to ask you a small favor. We are a non-profit foundation, and unlike some other organizations, we have no shareholders and no products to sell you. We are committed to responsible journalism, free from commercial or political influence, that allows you to make informed decisions about your future health.

All our news and educational content is free for everyone to read, but it does mean that we rely on the help of people like you. Every contribution, no matter if it’s big or small, supports independent journalism and sustains our future. You can support us by making a donation or in other ways at no cost to you.

Bryan Johnson Thinks AI Should Run Your Life

In this video, Bryan Johnson, founder and CEO of Blueprint, shared his ideas about the role of artificial intelligence (AI)...

Lifespan News – GPT-4 for Medicine

On this episode of Lifespan News, Emmett Short discusses how GPT-4 is making waves in the medical field. Script Hands...

Lifespan News – Young Blood for Brain Boosting

This episode of Lifespan News, presented by Emmett Short, discusses a study showing that the brains of old mice benefit...

Lifespan News – Exercise and Supplements

Emmett Short talks about a recent meta-study of exercise and supplements on this episode of Lifespan News. Script We all...

CategoryLifespan News, News
  1. jonathanweaver
    August 18, 2021

    CRISPR will re ready for therapeutic as well as cosmetic use in humans in the 2030-2035 timeframe. I can imagine people in 20 years routinely and inexpensively modify their DNA for health/cosmetic purposes.

Write a comment:


Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.