This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore NAD+ biology and take a look at a recent publication by Dr. David Sinclair. During the show, we covered the new publication, looked at a number of other related papers, and had a lively discussion about NAD+ biology in general, including the various precursor molecules and their potential to treat age-related decline.
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell metabolism, 27(3), 529-547.