For the August Journal Club, we took a look at a new paper that shows inhibiting TGFβ can boost liver regeneration . We also discussed another related paper from 2015 by Conboy et al. which showed regeneration in aged mice was possible if TGFβ was inhibited . Taken together, the two papers both confirm that systemic inflammatory signaling holds back tissue regeneration and if we can remove those signals we may potentially be able to regenerate organs and tissue in aged people in the future.
 Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., … & Ferreira-Gonzalez, S. (2018). TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science translational medicine, 10(454), eaan1230.
 Yousef, H., Conboy, M. J., Morgenthaler, A., Schlesinger, C., Bugaj, L., Paliwal, P., … & Schaffer, D. (2015). Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget, 6(14), 11959.