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Jonathan Clark on Cross-Linked Collagen at EARD2020

A decrease in enzymatic cross-links may be a cause of tendon fragility.

Dr. Jonathan ClarkDr. Jonathan Clark

At Ending Age-Related Diseases 2020, Dr. Jonathan Clark of the Babraham Institute gave a presentation on the effects of cross-linked collagen on the elastic deformation of our tendons, which connect muscles and bones. The conventional wisdom is that as we age, our tendons lose the ability to stretch, but Dr. Clark presents evidence offering a new perspective on this idea while showing how the collagen is becoming more fragile. He shows the various compounds that cause collagen to irreversibly cross-link, including glucosepane, and he shows that one reversible, enzymatic cross-link, HLNL, actually sharply decreases with age.

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