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Dr. Aubrey de Grey: Undoing Aging

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Dr. Aubrey de Grey is the Chief Science Officer and founder of the SENS Research Foundation (SRF) and one of the original proponents of a damage repair-based approach to aging and age-related diseases. His work has inspired many others to think about aging differently and entertain the idea that, perhaps, we do not have to accept the suffering that age-related diseases cause.

In this article, Dr. de Grey writes a summary of the strategy of rejuvenation based on a periodic approach to repairing age-related damage. This approach has steadily gained increasing traction as the data supporting it grows; certainly, the clearance of senescent cells, a SENS approach, has enjoyed great public interest recently. Interestingly, while he certainly is not the only researcher to have suggested the idea, he was talking about removing senescent cells as a therapy back in 2002 [1].

The work of Dr. de Grey has also encouraged others to pursue repair based approaches to aging, including the much-cited Hallmarks of Aging, which is almost certainly inspired by SENS [2].

The SRF has actively funded research into senescent cells, and companies like Oisin are a direct result of the work of the foundation and are now developing therapies to bring to market. Imagine what might be achieved if all seven of the SENS damages received the same level of support and interest. As a community, we can help to make this happen and maybe have a shot at healthy and longer lives as a result.


In the face of the increasing amount of research and data in support of SENS, there has been a large shift in academic enthusiasm and support for the repair approach to aging. The stakes are high here, but ultimately, if we can develop the tools and methods we need to address the damage that aging causes, we have a real shot at longer and most importantly healthier lives.


[1] Grey, A. D., Ames, B. N., Andersen, J. K., Bartke, A., Campisi, J., Heward, C. B., … & Stock, G. (2002). Time to talk SENS: critiquing the immutability of human aging. Annals of the New York Academy of Sciences, 959(1), 452-462.

[2] López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.

About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
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